MELANOMA CRITICAL DEBATES - PART 10 pptx

... 198–200, 199 high-dose 199 low-dose 199–200 trials in stage II 200–1 g-interferon 197, 233, 234, 243 interleukins IL-2 195, 197, 222, 238, 243 IL-4 243 IL -1 0 243 IL-12 243 in-transit melanoma metastasis ... melanoma and 18–23 cutaneous melanoma 19–20, 20, 22 duration of exposure 21 ocular melanoma 20 avb3 integrin 240 intercellular adhesion molecule-1 (ICAM-1) 222 a-interferon (IFN...

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... Stevenson C, Davies RJH. Photosensitisation of guanine-specific DNA damage by 2-phenylbenzimidazole and the sunscreen agent 2-phenyl- benzimidazole-5-sulfonic acid. Chem Res Toxicol 1999; 12: 38–45. ized ... of melanoma. These are the genes CDKN2A on chromo- some 9p (coding for the cyclin-dependent kinase inhibitor, p16 INK4A ), and the cyclin-dependent kinase, CDK4. Both genes play a critic...

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... published 2002 Library of Congress Cataloging-in-Publication Data Melanoma: Critical Debates /edited by J. A. Newton Bishop, M. Gore. p. cm. ISBN 0-6 3 2-0 577 2-6 1. Melanoma. I. Bishop, J. A. Newton (Julia ... Martin [DNLM: 1. Melanoma. QZ 200 C437 2001] RC280.M37 C48 2001 616.99¢477—dc21 20 0103 5202 ISBN 0-6 3 2-0 577 2-6 A catalogue record for this title is availabl...

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... 1.01 (95% CI= 0.46–2.28) when using hospital- and population-based studies combined or population-based stud- ies alone, respectively. Thus, from this meta-analysis, one must conclude that there ... is sub- Melanoma: Critical Debates Edited by Julia A. Newton Bishop, Martin Gore Copyright © 2002 Blackwell Science Ltd Recent studies suggest that tanning is a direct consequence of UV-in...

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... for the regular follow-up of selected high-risk individuals re- sults in thinner melanomas being diagnosed, as concluded from a Dutch study on high-risk patients from melanoma- prone families who ... patient (because of a high-risk profile) need regular follow-up? If so, refer to pigmented lesion clinic Part 2: Diagnosis, Screening and Prevention Melanoma: Critical Debates Edited by...

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... to treat- ments such as cryotherapy, radiotherapy, laser ablation and the topical appli- cation of azelaic acid, which have all been used for lentigo maligna [5]. Melanoma: Critical Debates Edited ... detection of melanoma in the Provence–Alpes– Cote-d’Azur area 1989: lessons of an experience. Ann Dermatol Venereol 1992; 119: 105 –9. 18 Bulliard J-L, Raymond L, Levi F, et al. Prevent...

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... of 2- uoro-2-deoxyglucose (FDG)-PET scanning was re- ported for detection of melanoma metastases [33,34]. Although access to PET is at present limited, it is a promising tool in staging of melanoma ... that PCR- positive–H&E-negative lymph node patients have survival rates intermediate between those patients who are PCR- and H&E-positive and those who are both PCR- and H&E-n...

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... disease. DTIC is metabolized to the active agent MTIC ( 5-( 3-methyl- 1- triazeno)imidazole-4-carboxamide) which methylates cellular molecules in- cluding DNA. Twelve different DNA lesions are produced ... set- ting in high-risk melanoma patients. Interleukin 2 Interleukin 2 (IL-2) has modest activity in stage IV melanoma but so far has not been evaluated widely in the adjuvant sett...

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... al. [38] gp100 209 2M IFA 11 3 mixed IFA, IL-2 31 13–1 CR, 12 PR Maeurer et al. [39] MART-1, gp100, MF59 or Tyrosinase 368 Local IL-12 Jaeger et al. [40,41] MART-1, gp100, GM-CSF (3 pt) 10 3–1 CR, Tyrosinase ... MR MART-1 *Peptides were Tyrosinase, gp100, MART-1 for HLA-A2 patients and MAGE-1A.1 for HLA- A1 patients. †CR, PR and MR, complete, partial and mixed responses, respectively. Abbre...

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... antigens. The cytokines involved in the T-cell response, such as IFN-g and IL-12, help drive the T-cell response towards cell- mediated immunity, whereas IL-4 and IL -1 0 drive the response towards humoral ... performed. In-transit melanoma metastasis High-risk primary melanoma (>1.5mm) of the limbs is prone to develop in- transit metastasis within 5 years in 6 10% of cases [2]. Thes...

Ngày tải lên: 09/08/2014, 15:20