MELANOMA CRITICAL DEBATES - PART 8 pot
... A24, B37, B44, DR11, DR13 MAGE-4A 55 11 22 MAGE-6 [63] 89 ? ? MAGE-12 89 ? ? MAGE-C1 [36] 37 53 BAGE 22 Cw1601 GAGE [63] 24 Cw6 LAGE [ 28] 50 SSX-2 [30] 43 NY-ESO-1 [29] 20–40 A2, A31 DAM [27] ... TGF-b [74,76] a-MSH [77] Shift of TH 1 TC 1 to TH 2 TC 2 IL-10, TGF-b, FasL [ 78, 79] Inhibition of migration of PGE 2 , tumour matrix [80 ,81 ] leukocytes from blood vessels VEGF [82 ] Tumour-med...
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... the detection of melanoma metastases. Ann Surg 19 98; 227: 764–9; discussion 769–71. 35 Macfarlane DJ, Sondak V, Johnson T, Wahl RL. Prospective evaluation of 2-[ 18F ]-2 -deoxy- D-glucose positron emission ... follow-up of high risk melanoma patients with whole-body 18F- fluorodeoxyglucose positron emission tomography: results of a prospective study of 100 patients [see comments]. C...
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... cm. ISBN 0-6 3 2-0 577 2-6 1. Melanoma. I. Bishop, J. A. Newton (Julia A. Newton) II. Gore, Martin [DNLM: 1. Melanoma. QZ 200 C437 2001] RC 280 .M37 C 48 2001 616.99¢477—dc21 2001035202 ISBN 0-6 3 2-0 577 2-6 A ... Offices: Osney Mead, Oxford OX2 0EL, UK Tel: +44 (0) 186 5 206206 Blackwell Science Inc., 350 Main Street, Malden, MA 0214 8- 5 0 18, USA Tel: +1 781 388 82 50 B...
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MELANOMA CRITICAL DEBATES - PART 2 pdf
... interval Scotland, 1 988 [29] 1979 84 2.9† 1.3–6.4* ( 180 /120) Ontario, Canada, 1990 [30] 1 984 86 Males: 1 .88 † 1.20–2. 98* ( 583 /6 08) Females: 1.45† 0.99–2.13 Sweden, 1994 [3] 1 988 –90 1.3‡ 0.9–1 .8 (400/640) Belgium, ... Denmark 1 982 85 474/926 1.1 (0 .8 1.5) - Whiteman et al. [49] Australia 1 987 –94 50/156 2.2 (0.4–11.6) ≠ Westerdahl et al. [50] Sweden 1 988 –00 400/640 1 .8...
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MELANOMA CRITICAL DEBATES - PART 3 pptx
... one-third of those hereditary melanoma families contain- ing three or more affected first- or second-degree relatives show inheritance of MANAGING HIGH RISK MELANOMA PATIENTS 71 66 58 35 38 58 66 ... FEBS Lett 1997; 4 18: 87 –90. 74 Stevenson C, Davies RJH. Photosensitisation of guanine-specific DNA damage by 2-phenylbenzimidazole and the sunscreen agent 2-phenyl- benzimidazole-5-sulfo...
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MELANOMA CRITICAL DEBATES - PART 4 pps
... for the regular follow-up of selected high-risk individuals re- sults in thinner melanomas being diagnosed, as concluded from a Dutch study on high-risk patients from melanoma- prone families who ... in malignant melanoma re-excision specimens? Histopathology 19 98; 32: 566–7. 17 Salman SM, Rogers GS. Prognostic factors in thin cutaneous malignant melanoma. J Dermatol Surg Oncol 1990; 16:...
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MELANOMA CRITICAL DEBATES - PART 5 ppt
... Screening for cutaneous melanoma by skin self-examination. J Natl Cancer Inst 1996; 88 : 17–23. 48 Elwood JM. Skin self-examination and melanoma. J Natl Cancer Inst 1996; 88 : 3–5. 49 Girgis A, Campbell ... disease- free survival rates were the same for the narrow (1cm) and wide (3cm) margin groups ( 8- year overall survival: 89 .6% and 90.3% respectively; 8- year disease-free sur...
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MELANOMA CRITICAL DEBATES - PART 7 ppt
... – – 340 EORTC 188 71/DKG -8 0 – – Stage III High-dose IFN 160 NCCTG – – 249 ECOG 1 684 ++ 479 ECOG 1690 + – Low-dose IFN 427 WHO-16 – – 490 EORTC/DKG – – Abbreviations: DFS, disease-free survival; ... II, et al. DTIC (NSC-45 388 ) and combination therapy for melanoma. I. Studies with DTIC, BCNU (NSC-409962), CCNU (NSC-79037), vincristine (NSC-67574), and hydroxyurea (NSC-32065). Cancer Treat...
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MELANOMA CRITICAL DEBATES - PART 9 pps
... and in-transit metastases of extremity melanoma. Reg Cancer Treat 1 988 ; 1: 33–6. 8 Lejeune FJ, Ruegg C, Liénard D. Clinical applications of TNF-a in cancer. Curr Opin Immunol 19 98; 10: 573 80 . 9 ... antigens. The cytokines involved in the T-cell response, such as IFN-g and IL-12, help drive the T-cell response towards cell- mediated immunity, whereas IL-4 and IL-10 drive the response t...
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MELANOMA CRITICAL DEBATES - PART 10 pptx
... neoplasia (CIN) 80 chemoimmunotherapy 205 chemotherapy 1 78 90 adjuvant 1 78 81 benefits 188 –9 for metastatic disease 182 8 combination 184 –5 high-dose 185 –6 optimizing 186 8 single agent 182 –3 281 Index Note: ... III 1 98 200, 199 high-dose 199 low-dose 199–200 trials in stage II 200–1 g-interferon 197, 233, 234, 243 interleukins IL-2 195, 197, 222, 2 38, 243 IL-4 243 IL-10 243 IL-...
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