MELANOMA CRITICAL DEBATES - PART 6 pot
... of 2- uoro-2-deoxyglucose (FDG)-PET scanning was re- ported for detection of melanoma metastases [33,34]. Although access to PET is at present limited, it is a promising tool in staging of melanoma ... In a cohort of 01224 364 860 7284 961 08 120 0.0 0.1 0.2 0.3 0.4 0.5 0 .6 0.7 0.8 0.9 1.0 P=0.004 SLN + SLN- Time Cumulative proportion surviving Complete + Censored Fig. 12 .6 Sentinel...
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... A24, B37, B44, DR11, DR13 MAGE-4A 55 11 22 MAGE -6 [63 ] 89 ? ? MAGE-12 89 ? ? MAGE-C1 [ 36] 37 53 BAGE 22 Cw 160 1 GAGE [63 ] 24 Cw6 LAGE [28] 50 SSX-2 [30] 43 NY-ESO-1 [29] 20–40 A2, A31 DAM [27] ... IFN-a 41 10 2–15 Marincola et al. [43] b.+IFN-a 82 24 NR Kruit et al. [ 36] b.+IFN-a (5 days) 17 41 2–37 b.+IFN-a (3 days) 25 20 4– >10 EORTC-MCG [55]* Decrescendo+IFN-a 66 18 3– > 36...
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... published 2002 Library of Congress Cataloging-in-Publication Data Melanoma: Critical Debates /edited by J. A. Newton Bishop, M. Gore. p. cm. ISBN 0 -6 3 2-0 577 2 -6 1. Melanoma. I. Bishop, J. A. Newton (Julia ... Newton (Julia A. Newton) II. Gore, Martin [DNLM: 1. Melanoma. QZ 200 C437 2001] RC280.M37 C48 2001 61 6.99¢477—dc21 2001035202 ISBN 0 -6 3 2-0 577 2 -6 A catalogu...
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MELANOMA CRITICAL DEBATES - PART 2 pdf
... (0.71–1 .60 ) - Holly et al. [47] USA 1981– 86 452/930 0 .62 (0.49–0.83) Ø Osterlind et al. [48] Denmark 1982–85 474/9 26 1.1 (0.8–1.5) - Whiteman et al. [49] Australia 1987–94 50/1 56 2.2 (0.4–11 .6) ≠ Westerdahl ... Drug Administration USA. Sunscreen drug products for over- the-counter human use: final monograph. Federal Register 1999; 64 : 2 766 6–93. 16 Bech-Thomsen N, Wulf H...
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MELANOMA CRITICAL DEBATES - PART 3 pptx
... affected first- or second-degree relatives show inheritance of MANAGING HIGH RISK MELANOMA PATIENTS 71 66 58 35 38 58 66 40 3339 7978 45 46 Fig. 6. 1 Typical pedigree of melanoma- prone kindred showing ... inhibitor, p 16 INK4A ), and the cyclin-dependent kinase, CDK4. Both genes play a critical part in the regula- tion of the cell cycle. The proportion of all cutaneous melanomas t...
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MELANOMA CRITICAL DEBATES - PART 4 pps
... 362 –7. 16 Kirkham N. What is there to find in malignant melanoma re-excision specimens? Histopathology 1998; 32: 566 –7. 17 Salman SM, Rogers GS. Prognostic factors in thin cutaneous malignant melanoma. ... for the regular follow-up of selected high-risk individuals re- sults in thinner melanomas being diagnosed, as concluded from a Dutch study on high-risk patients from melanoma- pron...
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MELANOMA CRITICAL DEBATES - PART 5 ppt
... Prev 19 96; 20: 566 –75. 52 Miller DR, Geller AC, Wyatt SW, et al. Melanoma awareness and self- examination practices: results of a United States survey. J Am Acad Dermatol 19 96; 34: 962 –70. 53 ... spreading melanoma. Cancer 1990; 66 : 387–95. 62 Douglass HM, McGee R, Williams S. Are young adults checking their skin for 120 CHAPTER 9 melanoma? Aust N Z J Public Health 1998; 22: 562...
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MELANOMA CRITICAL DEBATES - PART 7 ppt
... (NSC-45388) and combination therapy for melanoma. I. Studies with DTIC, BCNU (NSC-409 962 ), CCNU (NSC-79037), vincristine (NSC -6 7 574), and hydroxyurea (NSC-32 065 ). Cancer Treat Rep 19 76; 60 : 60 1–9. 45 ... prospective trial of DTIC (NSC-45388) alone versus BCNU (NSC-409 962 ) plus vincrisitne (NSC -6 7 574) in the treatment of metastatic malignant melanoma. Cancer Treat Rep19 76;...
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MELANOMA CRITICAL DEBATES - PART 9 pps
... antigens. The cytokines involved in the T-cell response, such as IFN-g and IL-12, help drive the T-cell response towards cell- mediated immunity, whereas IL-4 and IL-10 drive the response towards humoral ... performed. In-transit melanoma metastasis High-risk primary melanoma (>1.5mm) of the limbs is prone to develop in- transit metastasis within 5 years in 6 10% of cases [2]. These...
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MELANOMA CRITICAL DEBATES - PART 10 pptx
... 219–20 MUM-2 219 recognized by T cells 2 16 tumour rejection by 2 16 18 tumour-specific (TSA) 218, 219, 220 atypical naevi 61 –75, 62 , 95 biological explanation 65 6 definition 61 management 66 –7 meaning ... for cutaneous melanoma 263 6 hypofractionated 257–9 in mucosal melanoma 262 palliative treatment 259 role in melanoma 259 62 soft tissue disease 261 ras oncogenes 239, 2...
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