MELANOMA CRITICAL DEBATES - PART 4 pps

... for the regular follow-up of selected high-risk individuals re- sults in thinner melanomas being diagnosed, as concluded from a Dutch study on high-risk patients from melanoma- prone families who ... charts self-examination 3 Population-screening 4 Screening of selected high-risk phenotypes 5 Training of primary care workers seven-point check list ABCDs of the American Cancer Society 6 Set...

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... antigens. The cytokines involved in the T-cell response, such as IFN-g and IL-12, help drive the T-cell response towards cell- mediated immunity, whereas IL -4 and IL-10 drive the response towards humoral ... cuta- neous deposits. Hornsey [5] found responses in 21% (6/28) patients at 2–3 Gy, 55% (16/29) with 3–4Gy and 54% (20/37) with 4 8Gy. Overgaard [6] re- ported 35% (6/17) at <4Gy,...

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... (0.7–3.2) 0.7 (0 .4 1.2) Holly et al. [51] 121 adults 4. 4 (1.8–10.9) 3.8 (1 .4 10 .4) Osterlind et al. [20] 47 4 all 3.7 (2.3–6.1) 2.7 (1.6 4. 8) Weinstock et al. [52] 123 women 2 .4 (1.3 4. 4) 2.2 (1.2–3.8) Dubin ... published 2002 Library of Congress Cataloging-in-Publication Data Melanoma: Critical Debates /edited by J. A. Newton Bishop, M. Gore. p. cm. ISBN 0-6 3 2-0 577 2-...

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... 2.27 (1.3 4. 1) ≠ Graham et al. [42 ] USA 19 74 80 40 4/521 2.2 (1.2 4. 1) ≠ Herzfeld et al. [43 ] USA 1977–79 3 24/ 415 2.58 (1 .42 4. 69) ≠ Beitner et al. [44 ] Sweden 1978–83 523/505 1.8 (1.2–2.7) ≠ Elwoood ... (0.75–1.62) - Gallagher [45 ] Holman et al. [46 ] Australia 1980–81 507/507 1.1 (0.71–1.60) - Holly et al. [47 ] USA 1981–86 45 2/930 0.62 (0 .49 –0.83) Ø Osterlind et al....

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... FEBS Lett 1997; 41 8: 87–90. 74 Stevenson C, Davies RJH. Photosensitisation of guanine-specific DNA damage by 2-phenylbenzimidazole and the sunscreen agent 2-phenyl- benzimidazole-5-sulfonic acid. ... inhibitor, p16 INK4A ), and the cyclin-dependent kinase, CDK4. Both genes play a critical part in the regula- tion of the cell cycle. The proportion of all cutaneous melanomas that is at-...

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... Arch Surg 1991; 126: 43 8 41 . 15 Balch CM, Urist MM, Karakousis CP, et al. Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4mm): results of a multi-institutional randomized ... of malignant melanoma. Br Med J 1992; 3 04: 1012–15. 13 MacKie RM. Strategies to reduce mortality from cutaneous malignant melanoma. Arch Dermatol Res 19 94; 287: 13–15. 14 MacKie...

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... of 2- uoro-2-deoxyglucose (FDG)-PET scanning was re- ported for detection of melanoma metastases [33, 34] . Although access to PET is at present limited, it is a promising tool in staging of melanoma ... 12 .4) . These observations emphasize 051015 20 25 30 35 40 45 50 55 60 Time (months) Proportion disease-free .4 .1 .2 .3 .5 .6 .7 .8 .9 1.0 Disease-free survival (a) 051015 20 25 3...

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... trial – – 340 EORTC 18871/DKG-80 – – Stage III High-dose IFN 160 NCCTG – – 249 ECOG 16 84 ++ 47 9 ECOG 1690 + – Low-dose IFN 42 7 WHO-16 – – 49 0 EORTC/DKG – – Abbreviations: DFS, disease-free survival; ... prospective trial of DTIC (NSC -4 5 388) alone versus BCNU (NSC -4 0 9962) plus vincrisitne (NSC-675 74) in the treatment of metastatic malignant melanoma. Cancer Treat Rep1976; 60:...

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... A1,A2, A3, A 24, B37, B 44, DR11, DR13 MAGE-4A 55 11 22 MAGE-6 [63] 89 ? ? MAGE-12 89 ? ? MAGE-C1 [36] 37 53 BAGE 22 Cw1601 GAGE [63] 24 Cw6 LAGE [28] 50 SSX-2 [30] 43 NY-ESO-1 [29] 20 40 A2, A31 DAM ... report 1997 [55] Response rate (%) IL-2 only 14. 9 7.5 12 4 IL-2+chemotherapy 23.0 9.9 13 8 IL-2+IFN-a 20.8 10.5 24 14 IL-2+chemotherapy+IFN-a 44 .8 11 .4 22 12 *Patient collection n...

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... 198–200, 199 high-dose 199 low-dose 199–200 trials in stage II 200–1 g-interferon 197, 233, 2 34, 243 interleukins IL-2 195, 197, 222, 238, 243 IL -4 243 IL-10 243 IL-12 243 in-transit melanoma metastasis ... prognosis for malignant melanoma in the pregnant woman. Cancer 1951; 4: 3 24 34. 40 Conybeare RC. Malignant melanoma and pregnancy. Obstet Gynaecol 19 64; 24: 45 1 4. 41...

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