MELANOMA CRITICAL DEBATES - PART 3 pptx

... Acad Dermatol 1997; 37 : 942–7. 48 CHAPTER 3 72 Knowland J, McKenzie EA, McHugh PJ, Cridland NA. Sunlight-induced mutagenicity of a common sunscreen ingredient. FEBS Lett 19 93; 32 4: 30 9– 13. 73 Dunford ... of MANAGING HIGH RISK MELANOMA PATIENTS 71 6658 35 38 58 66 40 33 39 7978 45 46 Fig. 6.1 Typical pedigree of melanoma- prone kindred showing the age of onset of melanoma....

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... 238 , 242 trials in stage III 198–200, 199 high-dose 199 low-dose 199–200 trials in stage II 200–1 g-interferon 197, 233 , 234 , 2 43 interleukins IL-2 195, 197, 222, 238 , 2 43 IL-4 2 43 IL-10 2 43 IL-12 ... recurrence 236 new approaches 233 –4 prospects 236 –7 survival after 235 , 235 therapeutic 232 , 233 in-transit melanoma metastasis 230 –2, 232 keratitis 16 lactate dehydrogen...

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... published 2002 Library of Congress Cataloging-in-Publication Data Melanoma: Critical Debates /edited by J. A. Newton Bishop, M. Gore. p. cm. ISBN 0-6 3 2-0 577 2-6 1. Melanoma. I. Bishop, J. A. Newton (Julia ... given 1.6 (0.8 3. 0) Elwood et al. [37 ] 83 adults 3. 2 (1.6–6 .3) 1.5 (0.7 3. 5) Cristofolini et al. [38 ] 1 03 teens 1.2 (0.7 3. 2) 0.7 (0.4–1.2) Holly et al. [51]...

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... Ø Espinosa Spain 1990–94 116/ 235 0.48 (0 .34 –0.71) Ø Arranz et al. [52] Autier et al. [ 53] Europe 1991–92 418/ 438 1.50 (1.09–2.06) ≠ Wolf et al. [54] Austria 19 93 94 1 93/ 319 3. 5 (1.8–6.6) ≠ Westerdal ... 1.11 (95% CI=0 .37 3. 32) and 1.01 (95% CI= 0.46–2.28) when using hospital- and population-based studies combined or population-based stud- ies alone, respectively. Thus, from this m...

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... for the regular follow-up of selected high-risk individuals re- sults in thinner melanomas being diagnosed, as concluded from a Dutch study on high-risk patients from melanoma- prone families who ... charts self-examination 3 Population-screening 4 Screening of selected high-risk phenotypes 5 Training of primary care workers seven-point check list ABCDs of the American Cancer Society 6 Set...

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... 162 patients were 3. 05 [33 ] and 4.7mm [30 ,31 ]. The most common site for recurrence of subungual melanoma is in the regional lymph nodes, as with other cutaneous melanomas [31 33 ]. The only effective ... about 1 3% of all melanomas [30 33 ]. They occur mainly on the thumb and the great toe. They have a variety of histological features, the most common being acral lentiginous melanoma...

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... of 2- uoro-2-deoxyglucose (FDG)-PET scanning was re- ported for detection of melanoma metastases [33 ,34 ]. Although access to PET is at present limited, it is a promising tool in staging of melanoma ... emphasize 051015 20 25 30 35 40 45 50 55 60 Time (months) Proportion disease-free .4 .1 .2 .3 .5 .6 .7 .8 .9 1.0 Disease-free survival (a) 051015 20 25 30 35 40 45 50 55 60 Time (...

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... with two dose schedules of 5-( 3, 3-dimethyl-1-triazino) imidazole 4- carboxamide (DTIC) in the treatment of disseminated malignant melanoma. Cancer 1975; 35 : 36 8–71. 43 Bellett RE, Mastrelangelo ... Arch Dermatol 1996; 132 : 20–2. 33 Goldberg D, Stampien T. Q-switched ruby laser treatment of congenital nevi. Arch Dermatol 1995; 131 : 621 3. 176 CHAPTER 13 logically [33 ]....

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... A3, A24, B37, B44, DR11, DR 13 MAGE-4A 55 11 22 MAGE-6 [ 63] 89 ? ? MAGE-12 89 ? ? MAGE-C1 [36 ] 37 53 BAGE 22 Cw1601 GAGE [ 63] 24 Cw6 LAGE [28] 50 SSX-2 [30 ] 43 NY-ESO-1 [29] 20–40 A2, A31 DAM [27] ... al. [38 ] gp100 209 2M IFA 11 3 mixed IFA, IL-2 31 13 1 CR, 12 PR Maeurer et al. [39 ] MART-1, gp100, MF59 or Tyrosinase 36 8 Local IL-12 Jaeger et al. [40,41] MART-1, gp100, GM-CSF...

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... 1999; 17: 33 13 23. 12 Baselga J. New horizons: gene therapy for cancer. Anticancer Drugs 1999; 10 (Suppl. 1): 39 –42. 13 McCormick F. Cancer therapy based on p 53. Cancer J Sci Am 1999; 5 (3) : 139 – 43. 14 ... a clinical trial of G -3 1 39 in com- bination with dacarbazine against metastatic melanoma has been started recently [15]. NOVEL STRATEGIES FOR THE TREATMENT OF MELANOMA 2...

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