Handbook of clinical drug data - part 7 ppt

... to risk of breast cancer in middle-aged women. JAMA 1995; 274 :1 37 42. H ORMONAL D RUGS 71 3 ch08.qxd 8/13/2001 2:24 PM Page 71 3 t ¹⁄₂ . (Hypothyroid) 7. 5 ± 7. 1 days; (euthyroid) 6.2 ± 4 .7 days; ... ther- apy. Diabetes 1 976 ;25 :72 –4. 54. Heinemann L et al. Time-action profile of inhaled insulin. Diabet Med 19 97; 14:63 72 . 55. Setter SM et al. Insulin aspart: a new rapid-act...

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... bioavailable be- cause of extensive first-pass elimination; bioavailability increases in liver disease. 251 Covera-HS provides a 4- to 5-hr delay before releasing the drug. Ver- apamil has stereospecific ... dose of colestipol lowers cho- lesterol in an amount equivalent to 4 g of cholestyramine; a 4 g dose of colestipol tablets is about equivalent to 5 g of the granules. 273 –...

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... dosage of 225– 375 mg/day in 2 or 3 divided doses; (sustained-release) 75 mg once daily initially, increasing in increments of up to 75 mg/day at intervals of 4 or more days to a maximum of 225 ... the first of a class of selective serotonin-5-HT 1A re- ceptor partial agonists. It also has some effect on dopamine-D 2 autoreceptors and, like antidepressants, can downregulate ␤-ad...

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... activity of the product. From references 20 and 68 70 . 8 07 ch10.qxd 8/13/2001 2:46 PM Page 8 07 Drug- Induced Hepatotoxicity This table includes only those drugs with well-established records of hepatotoxic- ity. ... 1983;11:92–100. 72 . Jacqz-Aigrain E et al. CYP2D 6- and CYP3A-dependent metabolism of dextromethorphan in humans. Phar- macogenetics 1993;3:1 97 204. 73 . Woodwo...

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... nearly all isolates of Staphylococcus aureus and some isolates of coagulase-negative staphylococci are susceptible to these drugs. Methicillin- (actually ␤-lactam-) resistant staphylo- cocci have altered ... maximum of 8 g/day, de- pending on severity and site of infection. Reduce maintenance dosage by 50% with a Cl cr of 10–30 mL/min and by 75 % with a Cl cr <10 mL/min. Give on...

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... 170 0 terminal half-lives and V d of 170 0 L/m 2 . L/m 2 . 500–600 L/m 2 . Metabolism Both drugs are extensively metabo- Both agents are partially metabo- lized, initially to less active alco- ... Drug Interactions. (Aminoglutethimide) Several drug interactions can occur be- cause of the drug s enhancement of CYP3A metabolism; the effects of dexam- ethasone, digoxin, ... interrup...

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... containing Capsule con- Capsule con- Rectal suspen- coated pH mesalamine prodrug taining 5- taining ethyl- sion, sup- dependent cleaved by colonic ASA dia- cellulose- pository. (pH 7) , de- bacterial azoreductases. ... Selectivity of 5-HT 3 receptor antagonists and anti-emetic mechanisms of action. Anticancer Drugs 1992;3 :79 –85. 88. Holdsworth MT et al. Assessment of chemotherapy-...

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... status of the elderly can impact the outcome of drug therapy, and, conversely, drug therapy can affect nutritional sta- tus. 19,36, 37 ■ EVALUATING DRUG DATA FOR THE ELDERLY Because of age-related ... Both ranges of total drug represent the same concentration of unbound drug, 1–2 mg/L. The V d of drugs can be increased, decreased, or unchanged in renal failure pa- tien...

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... 2 97 321, 322–323 breastfeeding, 922–923 pregnancy, 8 87 ANTIASTHMATICS, 76 9 77 6, 77 7 78 1, 78 2 78 5, 78 6 78 9, 79 0 breastfeeding, 933 bronchodilators, 77 7 78 1 pregnancy, 8 97 indx.qxd 8/13/2001 3:49 PM Page 1089 Decreased ... formulas, 10 47 Albuterol, 76 9 77 0, 77 7 for anaphylaxis, 1001 breastfeeding, 933 interaction with lab test, 1 073 –1 075 , 1 079 pregnancy, 8 97...

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