Handbook of clinical drug data - part 4 pptx

... information. 348 ch 04. qxd 8/13/2001 1 :46 PM Page 348 360 ␤-ADRENERGIC BLOCKING DRUGS COMPARISON CHART (continued ) β HALF- EXCRETED DOSAGE CARDIO- LIFE UNCHANGED PROTEIN LABELED STARTING MAXIMUM DRUG ... bioavailable be- cause of extensive first-pass elimination; bioavailability increases in liver disease. 251 Covera-HS provides a 4- to 5-hr delay before releasing the drug. Ver-...

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... 1 946 ;212:211– 24. 81. Ascensao JL et al. Quinidine-induced neutropenia: report of a case with drug- dependent inhibition of granulo- cyte colony generation. Acta Haematol 19 84; 72: 349 – 54. 82. Geltner ... Not dose-dependent; although this reaction is not common, numerous fatalities have been reported. 14, 44 AGN Often brief and self-limiting; usually responds to withdrawal of...

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... mL/min) 45 0 mg/day; (Cl cr 10– 24 mL/min) 45 0 mg q 48 hr; (hemodialysis) use ganciclovir. Maintenance: (Cl cr 40 –59 mL/min) 45 0 mg/day; (Cl cr 25–39 mL/min) 45 0 mg q 48 hr; (Cl cr 10– 24 mL/min) 45 0 ... nearly all isolates of Staphylococcus aureus and some isolates of coagulase-negative staphylococci are susceptible to these drugs. Methicillin- (actually ␤-lactam-) resista...

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... IV dose of 740 mg/m 2 . V dss is 6 .4 ± 1.5 L; Cl is 2.2 ± 0 .4 L/min. Relatively little un- changed drug (1.1% of a dose), actifostine (1 .4% of a dose), or disulfide metabo- lite (4. 2% of a dose) ... proteins. Both drugs are extensively metabolized. The majority of a flutamide dose is excreted in the urine as 2-amino-5-nitro- 4- ( trifluoromethyl) phenol (inactive) with litt...

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... hepatically metabolized via CYP3A4 to the 1-hydroxy- and 4- hydroxy-metabolites; the 1-hydroxy-metabolite is at least as active as midazo- lam. Midazolam’s half-life is 1.8–6 .4 hr. Adverse Reactions. ... the first of a class of selective serotonin-5-HT 1A re- ceptor partial agonists. It also has some effect on dopamine-D 2 autoreceptors and, like antidepressants, can downregulate ␤-ad...

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... 19 94; 14: 385–98. 147 . Goldenberg MM. Critical drug appraisal: mesalamine in the treatment of inflammatory bowel disease. P & T 1997;(October) :49 8–510. 148 . Bonapace CR, Mays DA. The effect of ... first of a new class of antiemetic agents. Clin Pharm 1991; 10 :43 0 46 . 97. Grunberg SM et al. Randomized double-blind comparison of three dose levels of intravenous ondan...

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... Mosby-Year Book; 19 94: 225– 54. 42 . Mooradian AD, Thurman JE. Drug therapy of postprandial hyperglycaemia. Drugs 1999;57:19–29. 43 . Lebovitz HE. ␣-Glucosidase inhibitors in the treatment of hyperglycemia. ... constant-infusion ther- apy. Diabetes 1976;25:72 4. 54. Heinemann L et al. Time-action profile of inhaled insulin. Diabet Med 1997; 14: 63–72. 55. Setter SM et al. Insulin...

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... acid CONV 2 65 in 4 64 Flucytosine CONV 1 69 in 4 44 Ganciclovir CONV 2 60 in 4 45 Gentamicin CONV 1 30–50 in 4 46 48 HE 40 45 in 3 4 SYN 1 50–60 in 3 Isepamicin HE 42 –85 in 3 49 Imipenem/cilistatin ... pharmacotherapy. Drugs Aging 19 94; 4 :47 –55. 13. Woodhouse KW, James OFW. Hepatic drug metabolism and ageing. Br Med Bull 1990 ;46 :22–35. 14. Walker J, Wynne H. Review:...

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... SPARING ProcalAmine 3% b 0.68 1 .4 0 .46 35 24 5 41 47 3.5 735 FreAmine III 3% 0.68 1 .4 0 .46 35 24. 5 5 41 44 3.5 40 5 (with electrolytes) Aminosyn 3.5% M a 0.86 1.65 0.55 47 13 3 40 58 3.5 47 7 3.5% Travasol 0.55 ... AND ANTI-INFLAMMATORY DRUGS, 3– 54 antimigraine drugs, 3–9 antirheumatic drugs, 10–15 breastfeeding, 916–918 nephrotoxicity, 843 nonsteroidal anti-inflammatory dr...

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