Báo cáo y học: "Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis" doc

... assay; CCP3: cyclic citrullinated third-generation peptide assay; CFFCP1: chimeric fibrin/filaggrin citrullinated peptides 1; CFFCP2: synthetic chimeric fibrin/filaggrin peptides 2; CFFCP3: synthetic ... purposes) Vol 11 No 5 Research article Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptide...

Ngày tải lên: 09/08/2014, 14:22

... typically induced by external stimuli such as certain inflammatory cytokines (IL-6, IL-1β) and by certain growth factors. Extracellularly, TIMPs inhibit MMP activity by forming high- affinity ... MMPs. The amino-termi- nal domain of TIMP binds the active site of MMPs, inhibiting their proteolytic activity. The carboxy-terminal domain of cer- tain TIMPs has also the ability to form com...

Ngày tải lên: 09/08/2014, 06:23

... and distinct subsets of patients are characterized by the presence of autoantibod- ies such a rheumatoid factor and anti -citrullinated protein antibodies, we also performed a stratified analysis ... Immunol Lett 2008, 118:1-5. 31. Spolski R, Leonard WJ: The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer [review]. Curr Opin Immunol 2008, 20:295-301. .....

Ngày tải lên: 09/08/2014, 14:20

... synovial sublining by macro- phages, lymphocytes, and other immune cells, and by intimal lining layer hyperplasia due to increased numbers of intimal macrophages and fibroblast-like synoviocytes (FLS) ... staining of rheumatoid arthritis synovial tissue with antibodies against RasGRF1 and cell-specific markersRepresentative double staining of rheumatoid arthritis synovia...

Ngày tải lên: 09/08/2014, 14:22

... pharmacy data. While clinical disease activity measures remain the gold standard for assessing effectiveness in RA, the many large administrative data sources in the U.S. and internationally are ... written informed consent. VARA contains demographic, clinical and RA-specific information including disease activity scores (DAS), as assessed by physicians using the DAS28 [23] and...

Ngày tải lên: 25/10/2012, 10:45

... cascade of cytokines and chemokines necessary for tissue eosinophilia without involvement of draining lymphoid tissues. We studied the induction of lung allergic in- flammation in mice lacking ... the last intranasal challenge. Briefly, mice were maintained inside a whole-body plethysmograph (Buxco, Troy, NY) capable of meas- uring changes in airflow and trans-thoracic p...

Ngày tải lên: 03/11/2012, 11:24

... between these peptides and cysteine-free peptides recently described in the venom of spiders and insects. Parabutoporin and opistoporin 1 were synthesized chemically and preliminary studies on ... pandinin 1 contains only one charged amino acid in this fragment. Parameters that might in uence antibacterial activity that differ between opistoporin 1 and pandinin 1 are the...

Ngày tải lên: 21/02/2014, 15:20

... full-length proteins. Keywords: calretinin; calcium; calbindin D 28k ; EF-hand; NMR secondary structure. Calretinin (CR) and calbindin D 28k (Calb) are homologous calcium-binding EF-hand proteins with ... (B) 45 Ca-overlay of the blot shown in part A indicating that CR and GST fusion products of CR fragments bind 45 Ca. Fig. 6. ‘Glycine 6’ of the calcium-binding loop is a sensitiv...

Ngày tải lên: 22/02/2014, 07:20

... dimerization in helix IV (Figs 3 and 5). The binding of Ca 2+ to calhepatin increases its intrinsic fluorescence intensity and k max . This result, the decrease in the protein hydrodynamic volume, and ... by the increase in its intrinsic fluorescence intensity and k max , the decrease in the apo-calhepatin hydrodynamic volume, and the Ca 2+ - dependent binding of the prote...

Ngày tải lên: 08/03/2014, 22:20

... functional. To identify the hydroxylase component of the complex we performed single-turnover assays, in the absence of the Tomo F subunit, by measuring the ability of Tomo H, Tomo C and Tomo D, in each possible ... mass of about 10, 38 and 57 kDa, the expected molecular size of recombinant subunits B, E and A, respectively. The identity of the proteins was further check...

Ngày tải lên: 17/03/2014, 10:20