Báo cáo y học: "New data favouring that neurotrophins are of importance in arthritis" pot

... present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects in ... in fibroblast-like synoviocytes, as seen by ELISA analysis on culture supernatant. The authors concluded that infiltrating T lymphocytes and myeloid cells are the main source...

Ngày tải lên: 09/08/2014, 14:22

... specimens of non-RA patients were initially investigated, a recent follow up of that study [28] showed that citrullinated fibrin may also be present in synovial tissue of patients with other forms of joint ... in the inflamed synovium, especially in the synovial fluid. Because granulocytes have a lifespan of only about 3 days, they will die in large numbers at the site...

Ngày tải lên: 09/08/2014, 01:23

... lipoxygenase activity is defined as the amount of enzyme that absorbs 1 mmol of O 2 in 1 min. GLOX activity was measured by O 2 uptake in a reaction system containing 3 m M glyoxal in 20 mM sodium tartrate ... In contrast, the results obtained in the present study clearly indicate that tartrate itself was oxidized by MnP to produce glyoxal (Figs 1–3), thereby assisting chain...

Ngày tải lên: 24/03/2014, 04:21

... M: Combination of clozapine and maprotiline in refractory psychotic depression. Eur Psychiatry 2002, 17(8):484. Annals of General Psychiatry 2006, 5:20 http://www.annals-general-psychiatry.com/content/5/1/20 Page ... third line treatment for psychotic depression, in improving mood and psychotic symptoms', there remains much uncertainty and we would support further research in t...

Ngày tải lên: 08/08/2014, 21:20

... protein-protein interaction domains. Cbl The Cbl family E3 ligases are composed of an amino-terminal tyrosine kinase binding domain for substrate recognition, a RING domain, a proline-rich domain, ... substrates are polyubiquitinated in that four or more ubiquitins form a chain by ligating the carboxyl terminus of free ubiquitin to Lys48 of the previously attached ubiquitin prot...

Ngày tải lên: 09/08/2014, 07:20

... hematoxylin and eosin; IL: inter- leukin; iNOS: inducible nitric oxide synthase; IVM: intravital microscopy; NF: nuclear factor; PC: phosphatidylcholine; PCR: polymerase chain reaction; PMN: polymorphonuclear; ... [34]. Other in vitro data have shown that dipalmitoylphosphatidylcholine modulates the inflammatory functions of monocytic cells [35] and that a mixture of PC and phosp...

Ngày tải lên: 09/08/2014, 14:20

... disease severity of CIA in mice. In our study we used a well-established model of smoke-induced emphysema in mice [20,21]. In the course of this model, mice develop a progressive infiltration of inflammatory ... Therapy Vol 11 No 3 Lindblad et al. Page 2 of 8 (page number not for citation purposes) the stimulating effect of nicotine on collagen and gly- cosaminoglycan synt...

Ngày tải lên: 09/08/2014, 14:21

... genetics in plants, indicating that perfect inverted repeat transcripts are readily accepted by small RNA biogenesis pathways. Interestingly, there exists a clear continuum of hairpin-derived ... protein- coding gene prediction. It is clear that more data on the efficiency and specificity of miRNA processing are desirable, especially as all entries in the miRBase registry...

Ngày tải lên: 09/08/2014, 22:24

... resistin and adip- sinareproteinmediatorssecreted by adipocytes and macrophages within the adipose tissue [3]. Leptin and resistin are usually pro-inflammatory, while adiponectin has mainly anti-inflammatory ... effects of inhaled fluticasone sug- gesting that resistin may be a feature and biomarker of steroid-sensitive phenotype of asthma. This relation may be explained by the find...

Ngày tải lên: 11/08/2014, 03:20

... within the adipose tissue [3]. Leptin and resistin are usually pro-inflammatory, while adiponectin has mainly anti-inflammatory properties [3]. Leptin levels increase in obesity [4] and leptin ... favourable anti-inflammatory activ ity of fluticasone, we studied the effects of this adipokine on human THP-1 macrophages. Interestingly, resistin (0.1 - 2 μg/ml) increased production of...

Ngày tải lên: 11/08/2014, 06:22