Báo cáo y học: "T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis" docx
... AGGGACAA-3' IFN-γ 5'-GAAAGACAACCAGGCCATCAG-3' 5'-TCATGAATGCATCCTTTTTTGC-3' IL-4 5'-CCACGGAGAACGAG CTCATC-3' 5'-GAGAACCCCAGACTTGTTCTTCA-3' IL-17 5'-GGGAAGTTGGACCACCACAT-3' ... infiltration and participate in a number of inflammatory and destructive events, such as synovial hyperplasia, pannus for- mation, cartilage and bone erosi...
Ngày tải lên: 09/08/2014, 13:22
... fibrillated areas. Even in areas that had almost normal surface layers and safranin O staining patterns, Sulf expression was higher than in normal cartilage from young healthy donors. The TM joint is an ... Sulf-1 and Sulf-2 are highly expressed in OA carti- lage, especially in clusters and even in normal-appearing carti- lage in OA joints. The ability of Sulfs to regulate...
Ngày tải lên: 09/08/2014, 10:23
... Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, Okuno T, Fujiyama Y, Bamba T: IL-17 stimulates inflammatory responses via NF- κκ B and MAP kinase pathway in human colonic myofibroblasts. ... revealed that both synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as dynamic partners in a mutual activation feedback, via secretion of c...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... 5'- CCCAAGCAATACCCAAAGAA-3', reverse 5'-CATCAGAG- GCAAGGAGGAAA-3'; for monocyte chemoattractant pro- tein-1 (MCP-1), forward 5'-AGCCAGATGCAGTTAACGC-3', reverse 5'-CTGATCTCATTTGGTTCGGA-3'; ... 2 Histological analysis of the hindpawsHistological analysis of the hindpaws. (a) Representative haematoxylin and eosin stained section from a control mouse sh...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "TWEAK: a novel biomarker for lupus nephritis" pot
... array of cytokines, chemokines and cell adhesion molecules. TWEAK plays a role in tissue inflammation, repair and regeneration in many diseases, including SLE [5]. In a mouse model of SLE, the absence ... ischaemic injury has anti- inflammatory effects [5]. In the current paper by Schwartz and colleagues, TWEAK was assessed as a biomarker for LN in both cross-sectional...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population"
... general urology outpatient clinic at a Veterans Administration hospital in Brooklyn, NY. It included questions on lower urinary tract symptoms (LUTS) with 0-5 point scale and on quality of ... questionnaire. Table 1 summarizes the demographic data. Mean age was 68 years old (quartile range: 59-77). The major ethnicities were European American (44%), African American (37%) and...
Ngày tải lên: 25/10/2012, 11:35
Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx
... D11–13 (5¢-ATGGACGGAATCGTCACTGAAGTTGCAGTTA GAGGATCTGACGAACTACTCTCAGGC-3¢ )and reverse primer R1 (5¢-ATTGGATCCTTATACACGAGA AGGAGCACC-3¢) to generate the pnPTB-NLD-I D11-13 mutant; forward primer F1 (5¢-GGCAGGCATTCAGTC GACATGGACGGAATCGTCACT-3¢) ... exon in the c-src, c-aminobutyric acid A c2 receptor, clathrin light chain B, N-methyl- D - aspartate premRNA [36,37]. Interestingly, a PTB h...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx
... Clinical Diagnostics, Markham, Ontario, Can- ada), with multilayered slides used to measure TC, HDL, and TGs, whereas a dual chamber package was used to assess LDL, apolipoprotein (Apo) A and ApoB. ... suggests that MTX may protect against its development. This association has also recently been observed in a study by Zonana-Nacach and colleagues [30]. In that study, this asso...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... SLE and age-matched controls were evaluated clinically, with magnetic resonance imaging of the brain and CSF analyses. Levels of tau, amyloid precursor protein (APP), β-amyloid protein (A 42), and transforming ... mechanisms of neuropsychiatric manifestations are still the subject of intense investiga- tions, but autoantibody and cytokine-mediated neural dys- function, intracranial an...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population" docx
... haplotype exhibited a strong association with late onset, radiographically severe, and functionally poor OA of the knee, and in particular with male sex (Tables 5 and 6). However, the TAA and CAG ... 44:487-490. 17. Tanaka Y, Sasaki M, Kaneuchi M, Shiina H, Igawa M, Dahiya R: Polymorphisms of estrogen receptor alpha in prostate cancer. Mol Carcinog 2003, 37:202-208. 18. Tanaka...
Ngày tải lên: 09/08/2014, 01:23