Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot

... cardiac injuries, at least partially by shifting the microenvironment at the injury sites from proinflammatory to anti-inflammatory [55-57]. In a murine pulmonary fibrosis model, MSCs inhibited ... charac- terized in vitro by their extensive proliferative ability in an uncommitted state while retaining the potential to differentiate along various lineages of mesenchymal origin, includin...

Ngày tải lên: 09/08/2014, 13:22

... underline the potential role of cytokines in maintaining chronic inflammation in vivo. An alternative explanation for persistent synovial inflammation despite enriched numbers of CD4 + CD25 + T cells ... of inflammatory cytokines and of antigen-presenting cells that are able to engage costimulatory molecules on synovial T cells, CD25 + CD4 + T cells might expand locally in the rh...

Ngày tải lên: 09/08/2014, 06:22

... curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above what is seen with rituximab alone, may lead ... in the lymphoma experience. Competing interests RE has received support from Genentech for investigator and industry sponsored clinical trials, basic laboratory work and consultations regar...

Ngày tải lên: 09/08/2014, 08:22

... RA. Introduction Interleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promoting inflammation by inducing a variety of pro-inflammatory media- tors, ... of TH-17 cells in RA SF was determined by flow cytometry. IL-17 levels were quantified in synovial tissue from RA, OA and normal individuals by ELISA and IL-23 was identifie...

Ngày tải lên: 09/08/2014, 10:23

... Gavin MA, Rudensky AY: A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005, 6:1142-1151. 17. Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF- ββ 1 maintains suppressor ... active systemic lupus erythematosus. J Immunol 2007, 178:2579- 2588. 51. Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH: Altered frequency and migration capacity of CD4 + CD25 + regula...

Ngày tải lên: 09/08/2014, 13:22

... 9 delivered intravenously in animal models of double toxin-induced multiple system atrophy-parkinsonism [30], lupus nephritis [31], and clinical trials of ischemic stroke [23], multiple system atrophy ... phe notype in the polyglutamine * Correspondence: wh9801@yahoo.com.tw; kslee@vghtpe.gov.tw 1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan 8 Center for S...

Ngày tải lên: 10/08/2014, 10:20

... included but minimizes the risk of systematic biases and false-positive findings. In the analysis of the infiltrating leukocytes from the innate immune system, a first striking feature of BD synovitis ... the synovial sublining of BD and PsA, indicating that there is no systematic bias in local inflammation between the two study groups (Figure 1). Further analysis of the synovial leukocyt...

Ngày tải lên: 09/08/2014, 01:22

... was originally shown to be restricted to activated T lympho- cytes [5,22,23] and could be observed in resting T lym- phocytes, B lymphocytes, monocytes or granulocytes [20,24]. In contrast, Th2 lymphocytes ... to synovial fibroblasts, identified by an antibody against prolyl-4-hydroxylase (data not shown). In 10 OA samples examined, there was stain- ing for CXCR1 protein on a few macrop...

Ngày tải lên: 09/08/2014, 01:23

... approach were largely in oncology, many new reports are emerging in other fields including infectious diseases and pharmacology, and applications in autoimmunity have been recently reported by our group ... groups (working in MS and SLE) by including patients with RA and IDDM, and by offering direct comparisons between them. The similar gene expression findings in these clinically d...

Ngày tải lên: 09/08/2014, 01:23

... unstimulated endothelial cells or matrix proteins such as laminin [8]. What is the relevance of these findings in terms of our understanding of RA? Increased angiogenesis is thought to be crucial in supplying nutrients ... dysfunction in RA. This was certainly seen in the study of Herbrig and colleagues, who studied blood flow in the forearm following infusion of acetylcholine. Va...

Ngày tải lên: 09/08/2014, 07:20