Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
... cardiac injuries, at least partially by shifting the
microenvironment at the injury sites from proinflammatory to
anti-inflammatory [55-57]. In a murine pulmonary fibrosis
model, MSCs inhibited ... charac-
terized in vitro by their extensive proliferative ability in an
uncommitted state while retaining the potential to
differentiate along various lineages of mesenchymal origin,
includin...
Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx
... underline the potential role of cytokines in maintaining
chronic inflammation in vivo.
An alternative explanation for persistent synovial inflammation
despite enriched numbers of CD4
+
CD25
+
T cells ... of inflammatory cytokines and of
antigen-presenting cells that are able to engage costimulatory
molecules on synovial T cells, CD25
+
CD4
+
T cells might
expand locally in the rh...
Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf
... curious finding in the lymphoma
experience is that combining epratuzumab with rituximab,
although not increasing the overall clinical response rate
above what is seen with rituximab alone, may lead ... in the lymphoma experience.
Competing interests
RE has received support from Genentech for investigator and
industry sponsored clinical trials, basic laboratory work and
consultations regar...
Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf
... RA.
Introduction
Interleukin (IL)-17 may play a critical role in the pathogenesis
of rheumatoid arthritis (RA). IL-17 is capable of promoting
inflammation by inducing a variety of pro-inflammatory media-
tors, ... of TH-17 cells in RA SF
was determined by flow cytometry. IL-17 levels were quantified
in synovial tissue from RA, OA and normal individuals by ELISA
and IL-23 was identifie...
Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... Gavin MA, Rudensky AY: A function
for interleukin 2 in Foxp3-expressing regulatory T cells. Nat
Immunol 2005, 6:1142-1151.
17. Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF-
ββ
1 maintains
suppressor ... active
systemic lupus erythematosus. J Immunol 2007, 178:2579-
2588.
51. Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH: Altered
frequency and migration capacity of CD4
+
CD25
+
regula...
Báo cáo y học: "Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cell" ppsx
... 9
delivered intravenously in animal models of double
toxin-induced multiple system atrophy-parkinsonism
[30], lupus nephritis [31], and clinical trials of ischemic
stroke [23], multiple system atrophy ... phe notype in the polyglutamine
* Correspondence: wh9801@yahoo.com.tw; kslee@vghtpe.gov.tw
1
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
8
Center for S...
Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot
... included but minimizes the risk of
systematic biases and false-positive findings.
In the analysis of the infiltrating leukocytes from the innate
immune system, a first striking feature of BD synovitis ... the
synovial sublining of BD and PsA, indicating that there is no
systematic bias in local inflammation between the two study
groups (Figure 1). Further analysis of the synovial leukocyt...
Báo cáo y học: "High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis" potx
... was
originally shown to be restricted to activated T lympho-
cytes [5,22,23] and could be observed in resting T lym-
phocytes, B lymphocytes, monocytes or granulocytes
[20,24]. In contrast, Th2 lymphocytes ... to synovial fibroblasts,
identified by an antibody against prolyl-4-hydroxylase (data
not shown). In 10 OA samples examined, there was stain-
ing for CXCR1 protein on a few macrop...
Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx
... approach
were largely in oncology, many new reports are emerging in other fields including infectious diseases
and pharmacology, and applications in autoimmunity have been recently reported by our group ... groups (working in
MS and SLE) by including patients with RA and IDDM,
and by offering direct comparisons between them. The
similar gene expression findings in these clinically d...
Báo cáo y học: "It’s all in the blood: circulating endothelial progenitor cells link synovial vascularity with cardiovascular mortality in rheumatoid arthritis" docx
... unstimulated
endothelial cells or matrix proteins such as laminin [8].
What is the relevance of these findings in terms of our
understanding of RA? Increased angiogenesis is thought to
be crucial in supplying nutrients ... dysfunction in RA. This
was certainly seen in the study of Herbrig and colleagues,
who studied blood flow in the forearm following infusion of
acetylcholine. Va...