Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps

... Changes in the methylation status of Review Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Aleksander ... of HAT activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling, may increase the DNA binding and...

Ngày tải lên: 09/08/2014, 11:20

... parenteral administration, including rapid onset of effect, infusion, and injection site reactions, which may result in expectation bias as well as unblinding. Most importantly, placebo has been necessary to prove inefficacy ... Trial in Rheumatoid Arthritis with Concomitant Therapy; COX-2 = cyclooxygenase-2; DAS = Disease Activity Score; DMARD = disease-modifying antirheuma...

Ngày tải lên: 09/08/2014, 01:22

... newly emerging, include anti -inflammatory activities and therefore have important implications for the treatment of chronic inflammatory diseases. Keywords: apolipoprotein A-I, cytokines, inflammation, ... levels may inversely correlate with disease activity. The observation that apoA-I can infil- trate and be retained at the inflammatory site suggests that apoA-I may inhibit the...

Ngày tải lên: 09/08/2014, 01:24

... characterized by chronic prolifer- ative synovitis, with hyperplasia of the synovial lining cells, inflammatory cell infiltration and angiogenesis in the sublining cell layer. Hyperplastic synovial lining ... and bone, destroy- ing the joint. MMPs, mainly produced in FLS, play a central role in arthritic joint destruction. Beyond the proof that the expres- sions of MMP-2 and...

Ngày tải lên: 09/08/2014, 07:20

... frequencies of SNPs linked to RA have been already reported [8]. Analysis of RA-associated SNPs in solute carrier family 22 members 4 and 5 (SLC22A4 and SLC22A5) [9] and in protein tyrosine phosphatase (PTPN22) ... primer). Results and discussion In marked contrast to previous findings, no polymorphic alleles (neither thymine at position 40 nor cytosine at position 1,400) we...

Ngày tải lên: 09/08/2014, 07:20

... evalua- tion of joint activity, therefore, is a prerequisite of disease activ- ity assessment in RA. In this study, we showed that the assessment of joint activity in the feet, beyond assessment of joint ... measures of disease activity In an exploratory analysis, we employed the 32-joint counts to calculate disease activity indices using the DAS28 and SDAI form...

Ngày tải lên: 09/08/2014, 10:20

... recognition that clinical assessment (measuring and noting the change in index and the disease activity state attained) early in the course of therapy (3 to 6 months after initiation of therapy) allows ... of the type of therapy or disease duration, however, 3 months after initiation of treatment the disease activity – as assessed by the Simplified Disease Activity I...

Ngày tải lên: 09/08/2014, 10:23

... was no significant change in paraoxonase activity in relation to illness episodes, whereas the lowest values of this activity were seen in manic patients. In contrast, paraoxonase activity was ... purpose of this study was to investigate the variations of paraoxonase activity and lipid profile in bipolar I patients, and the association of this activity with the...

Ngày tải lên: 09/08/2014, 01:21

... standard enzyme assay, the kinetic studies (K m , k cat ) were completed for the active muteins and for the wild-type enzyme. Enzyme and protein assays Protein concentrations of the muteins and ... enzyme of ajmaline biosynthesis, as a new member, into the a/b hydrolase enzyme super- family. Most typical for this class of hydrolases are the three strictly conserved amino acids S...

Ngày tải lên: 24/03/2014, 04:21

... the study. YK, MT, and MI, con- ducted the laboratory work. YK, MT, AU, SO, AS, HK, KT, and YI were involved in the analysis and interpretation of data. YK, MT, and YI were involved in writing the ... heme oxygenase (HO)-1 and ferritin in hemophagocytic syndrome (HPS) and adult-onset Still's disease (ASD)Serum heme oxygenase (HO)-1 and ferritin in hemophagocytic...

Ngày tải lên: 09/08/2014, 06:22