Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx

... NF-κB to the nucleus [1-6]. These pathways are termed the classical or ‘canonical’ pathway and the alternative or ‘noncanonical’ pathway. The classical nuclear factor- κκ B pathway In the classical ... RANKL. Conclusion Both classical and alternative pathways of NF-κB activation regulate survival and activation of T and B lymphocytes at their sites of develop...

Ngày tải lên: 09/08/2014, 10:23

... Maryland, USA) has been reported previously [21]. Briefly, the primers and the TaqMan probe for gene RIZ encoding RIZ1 were designed and synthesized by Applied Biosys- tems (Carlsbad, California, ... used as the blank control. The cells were treated for 24 hr before the cell death rate was exam- ined by the trypan blue method. The cells were stained by 0.01% trypan b...

Ngày tải lên: 25/10/2012, 11:15

... care and use of laboratory animals from the Ministry of Science and Technology of the People’s Republic of China. Instruments HIFU ablation was performed with a HIFU tu- mor therapy system ... sources placed either outside the body (for treatment of tumors of the liver, kidney, breast, uterus, pancreas and bone) or in the rectum (for treatment of the pros-...

Ngày tải lên: 25/10/2012, 11:18

... Graphics workstation and was based on the structures of the human and porcine pancreatic lipases for the open form and on the horse pancreatic lipase for the closed form [16,18,19,30]. For homology modeling, the ... recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding and catalytic functions...

Ngày tải lên: 21/02/2014, 15:20

... used. RESULTS The enzymatic activity and molecular stability of the mutants The catalytic activity and the molecular stability of the mutants were assayed because a change in either of these parameters ... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, rat chymotrypsin B, is high...

Ngày tải lên: 22/02/2014, 07:20

... as alternative fits to the set of distances. The main advantages of the procedure are simple: the details of the calibration are precisely and unambiguously defined, it is fully automatic, and the ... standard cysteine residue in the DYANA library [53]. A pseudoatom was included instead of the HG atom and a bridge was formed by superimposition of the pseudoat...

Ngày tải lên: 22/02/2014, 07:20

... other, indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. g xx % g yy << g zz is typically found for type 2 sites. The grouping of the g-values ... simulation. Remarkable are the large hyperfine couplings A xx and A yy , and the ordering of the g values, both of which differ from those expected for type...

Ngày tải lên: 22/02/2014, 07:20

... N-glycosylation of AChE and BChE, which carry four and nine N-glycan chains, respectively [35]; we therefore compared the oligomeric patterns of wild-type BChE and mutants in which part of the N-glycosylation ... chimeras Ab and Ba, the rates of secretion were approximately 5% and 15% of the cellular con- tent per hour, respectively, and therefore appeared to be...

Ngày tải lên: 07/03/2014, 03:20

... way to explore the nature of the binding site and the process of catalysis for a-amylases. Although the overall structure and the tertiary folding of the polypeptide chains of different a-amylases ... stable and is not hydrolysed by a-amylases therefore, the products of hydrolysis are always b-glycosides. Selection of these glycosides as substrates has been b...

Ngày tải lên: 08/03/2014, 09:20

... respectively. Purification of CCR5-myc-his For the purification of CCR5-myc-his we tested two different methods based on the presence of the six histidines at the C-terminus of the protein. The first ... membrane proteins allows the study of their behaviour in a membrane in the absence of other proteins, and the manipulation of their concentration and enviro...

Ngày tải lên: 08/03/2014, 09:20