clinical animal and epidemiologic studies of vitamin d and rheumatoid arthritis
báo cáo hóa học:" Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model" docx
... VH organised the clinical study, KK and MAR participated in the design of the studies and interpreted the data All authors read and approved the final manuscript 13 14 15 16 Acknowledgements We ... calculated with standard assumptions about independence, equivariance and normality Due to heteroscedacity, the logarithm of the following response variables was used: CD3, CD4, CD45, and Ki-67 SCID ... animals were bled and sacrificed The serum levels of calcipotriol and BDP were analyzed and determined to be below the detection limit (data not shown) Discussion The objective of this study was to...
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báo cáo hóa học: " Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions" pot
... analysis and drafted and edited the manuscript MD edited the manuscript PS managed patients in the studies and edited the manuscript MB designed the study and edited the manuscript LS designed the ... validated and widely used in studies of patients with CHD [26,27] Studies used for the analysis Seven studies of cardiac interventions conducted in the UK were used The studies are summarized in ... using data gathered within the studies at different time intervals (Table 1) Age and gender were recorded for all studies at study entry The studies included: Cost-effectiveness of functional cardiac...
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Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx
... with the development of COPD are largely speculative: 1) The association of VitD deficiency and reduced lung function could depend on the calcemic effects of VitD The vital capacity and total ... polymorphisms of VitD receptor (VDR) and VitD binding protein (DBP) have been identified that modulate the development of tuberculosis [96] The genotype tt (detected by Taq I digestion) is associated with ... CYP2R1 and subsequently by the cytochrome P450 enzyme 25hydroxyvitamin D- 1a-hydroxylase (CYP27B1) and converted to the bioactive 1,25-(OH) 2D3 , which has role in Ca and bone metabolism and, in addition,...
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Study of relationships between plasma 25hydroxyvitamin D and insulin resistance, and effects of vitamin D supplementation on insulin resistance in gestational diabetes mellitus
... study compared effects of two vitamin D doses The daily dose of 1500 IU resulted in better blood glucose and, although did not absolutely decreased IR, did reduced IR increase for that period ... Review of vitamin D 1.1.1 Chemical nature and metabolism of vitamin D Vitamin D exists in two forms, Cholecalciferol (Vitamin D3 ) and Ergocalciferol (Vitamin D2 ) Vitamin D is converted to 25(OH )D ... compared to placebo or higher vitamin D doses to lower ones reduced IR and improved blood glucose in pregnant women with and without GDM in a number of studies However, those studies included both...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
... with all doses of NSAIDs, and between licensed daily doses of celecoxib and licensed doses of NSAIDs NSAIDs were used at licensed doses, usually at maximum daily dose, and rofecoxib was used at 25 ... http:/ /arthritis- research.com/content/7/3/R644 Table Included studies of tolerability, adverse events, and endoscopically detected ulceration associated with celecoxib in arthritis Drug, dose, number randomised Study Details of participants ... Materials and methods Randomised, double-blind, controlled trials, of weeks' duration or longer with any dose of celecoxib and any comparator, in osteoarthritis or rheumatoid arthritis, were supplied...
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Báo cáo y học: " Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen" doc
... longitudinal studies on vitamin D variation during HAART; therefore we studied vitamin D status in a longitudinal cohort study of AIDS patients during the first year of HAART Methods Page of “severe ... and LDL level were determined by automated standard laboratory techniques Vitamin D status Plasma 25-(OH )D concentrations are presented using two different cut-offs,
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Abstract Introduction Gender as a predictor of outcomes of rheumatoid arthritis (RA) ... females and males were Introduction The possible influence of gender and gender-related variables on the phenotype, severity, and prognosis of rheumatoid arthritis (RA) appears to be of considerable ... [36]; duration of morning stiffness; lifestyle choices such as smoking and physical exercise; height and weight to calculate body mass index; and demographic data, including years of education and...
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Báo cáo y học: "Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis" doc
... and ~170-kDa species, several additional forms of FN that bear sequences from the N-terminal HBD were detected in OA and RA samples Each of the soluble species identified in this study, in addition ... described elsewhere [15] Six volumes of FT, diluted six-fold during affinity isolation, were submitted to 1D SDS–PAGE alongside one volume of the corresponding SF The weights of molecular standards ... [3,6–9], and fragmented forms of FN have been detected in synovial fluid (SF) and articular cartilage from patients with OA and patients with rheumatoid arthritis (RA) [10–17] On the basis of such...
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Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx
... levels of the messages (RA) Relative expressionand rheumatoid arthritis for hyaluronanof knees in 2, and -3 and hyaluronidase-1, -2, and -3 in the synovium of knees in osteoarthritis (OA) and rheumatoid ... produced and hyaluronan digested in the fluid The average molecular weight of newly produced hyaluronan may be R518 Arthritis Research & Therapy Vol No Yoshida et al reduced by the decreased expression ... 59 Normal aDetermined on x-ray frontal views of the tibiofemoral joints in accordance with the radiographic atlas recommended by the Osteoarthritis Research Society [32] SD, standard deviation...
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Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot
... were used to distinguish the three populations of interest: CD8+ T cells were defined as being TCR-αβ+, CD8+, and CD56-; NK cells as TCR-αβ- and CD56+; and NK T cells as TCR-αβ+ and CD56+ All ... recent studies using perforin-deficient and NKcelldepleted mice indicate that NK cells and perforin-based systems are also involved in the downregulation of immune responses through a direct ... the basis of the two-tailed independent t-test) Thus, it seems that suppressed NK function is not simply a result of reduced numbers of NK cells among patients with sJRA CD56dim and CD56bright...
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Báo cáo y học: "Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specime" pot
... orthopedics NT, KY, SN, and SY carried out the clinical studies of each case and performed targeted biopsy of synovial tissues with the informed consent of the patients MN conceived of the study, ... cells associated with a typical palisading structure and it had lower total scores and belonged to group II Additional studies will be needed to compare gene-expression profiles of such a case ... computer-controlled microscope stage and observed from the upper side with a charged-coupling device (CCD) camera The image was displayed, and the multilayered lining tissue and the normal-like lining tissue of...
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Báo cáo y học: "Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens" ppt
... 3β-hydroxysteroid dehydrogenase (converts delta androgens into delta androgens); 5α-DH, 5αdihydro; 5-α-R, 5α-reductase; 17β-HSD, 17β-hydroxysteroid dehydrogenase; ADIOL, androstenediol; ASD, androstenedione; ... synovial cells and synovial tissue of long-standing RA and OA patients in the advanced phase of the disease: Conversion of DHEA yielded high amounts of estrogens and 16α-hydroxylated products in relation ... RA and OA); Conversion of ASD and testosterone particularly yielded androgens with elevated levels of 5α-hydroxylated androgens in RA as compared with OA (general blockade of aromatization and...
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Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx
... receiving no DMARD treatment at the time of blood and synovial fluid sampling Recent radiographs of the hands and feet were obtained for all the patients The presence of bone erosions, defined as the ... contributed to the study design; clinical, laboratory, and statistical evaluation of material from RA patients; and preparation of the manuscript LD performed the collection and clinical analysis of ... with degenerative joint diseases and critical revision of the manuscript AT contributed to the conception of the study and study design, statistical evaluation of the results, and preparation of...
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Báo cáo y học: "Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis" pps
... characterisation of blood derived DC subsets Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) peripheral blood (PB) plasmacytoid DC subsets dendritic cells (pDCs) and myeloid dendritic cells (mDCs) ... [39] TLR-induced cytokine production was therefore evaluated in disease DCs compared with healthy PB-derived DCs We purified mDCs and pDCs as already mentioned and evaluated the addition of the TLR2 ... number of cells (×104/ml) in rheumatoid arthritis and psoriatic arthritis peripheral blood and matched synovial fluid White blood cells Myeloid dendritic cells Plasmacytoid dendritic cells Rheumatoid...
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Báo cáo y học: " Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis" ppt
... stained in paraffin embedded tissue (RA, n = 4; OA, n = 6; ND, n = 4) with a modified sandwich technique as described previously [25] Sections µm thick were deparaffinized and endogenous peroxidase ... involved in in situ hybridization and PCR VK was involved in patient recruitment and performed the 'synovitis score' AP and CK conducted part of the patient recruitment and data evaluation FS, GAM and ... were fixed in 3% paraformaldehyde, washed in × standard saline citrate (SSC) for minutes, washed twice in 0.1 M triethanolamine hydrochloride, and acetylated with 0.25% acetic anhydride in 0.1...
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Báo cáo y học: "What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register" ppt
... years of IP and RA in NOAR, there was a definite increased risk of developing non-Hodgkin’s lymphoma (standardised incidence ratio, 2.4; 95% confidence interval, 1.2–4.2) The standardised incidence ... six tender joints and the absence of ankle swelling) were found to be important independent predictors of remission The model only had an explained variance of 17%, however, and clearly could not ... severity of arthritis, comorbidity) and treatment-specific factors (e.g drug and nondrug modalities, adverse events, patient adherence to prescribed treatment) All these factors interact and the prediction...
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Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot
... forward was estimated by means of linear mixed model analysis with an unstructured covariance matrix with random intercept and random slope [14] Measurements from weeks 0, 6, 14, and 22 and the ... datasets, and drafted the manuscript RW, PD, FVdB, HM, LDC, AP, MM, LV, and FDK recruited and observed the patients with arthritis BVC, SVL, BW, NV, AG, LB, RW, PD, Available online http:/ /arthritis- research.com/content/8/4/R112 ... and FDK participated in the study design RW and PD were the initial investigators of the Belgian infliximab expanded access program in which the patients were enrolled All authors have read and...
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Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... IF, MT, TM and RT were involved in conception, design, acquisition, analysis and interpretation of data LC, IF, TM and RT drafted and revised the manuscript All authors read and approved the final ... aboriginals and one patient of Pacific island origin Previously defined CV risk factors were common Of the patients studied, 63% were positive for RF and 76% had radiographic evidence of erosive disease ... the course of the study, a vascular thromboembolic syndrome, including MI, an episode of angina, stroke, TIA and diagnosis of PVD MI and angina accounted for the majority of CV morbidity, although...
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Báo cáo y học: "Detection of bone erosions in rheumatoid arthritis wrist joints with magnetic resonance imaging, computed tomography and radiography" ppt
... demonstrated a high specificity of bone erosions detected on MRI and radiography, and showed a markedly higher sensitivity of MRI than radiography when CT was considered the reference method Secondly, ... erosion score and the Sharp/van der Heijde radiographic erosion score) correlated with erosion volumes determined with CT and MRI Patients and methods Patients and control individuals Seventeen ... quantitative method for assessing bone erosions in RA patients could be a useful tool in longitudinal studies, including randomised controlled trials, but further studies, including studies of sensitivity...
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