Báo cáo y học: "α Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis" pptx

... changing, roles in the overall patho- genesis of this form of arthritis. In the light of the findings presented by Kim and colleagues [1], it is interesting that a small number of studies have ... disease severity [5]. In another study, EAE failed to resolve in TNFα -/- or TNFR -/- mice, suggesting that TNFα plays an important role in resolution of inflammation [6]. In m...

Ngày tải lên: 09/08/2014, 10:23

... (PsA). TNF acts in the early stages of the inflammatory process, during which it can stimu- late T-cell activation and induce the expression of IL-2, IFNγ receptors, proinflammatory cytokines (such ... may often stop treatment during an infection or elective surgery, any gaps in the use of the same anti-TNF treatment of less than 3 months were considered as continuous treatment. D...

Ngày tải lên: 09/08/2014, 14:20

... structural damage to joints. Preser- vation of joint integrity is closely associated with mainte- nance of functional capability. However, many patients with early RA are excluded from clinical studies ... space are robust, showing reproducible delineation of synovial thickening in small joints of the hands in patients with active RA, the analysis of such images does not necessa...

Ngày tải lên: 09/08/2014, 01:23

... to interfere with the inflammatory response in SLE by adminis- tering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy. Evidence ... expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus Model [Reference] TNF expression Effects of recombi...

Ngày tải lên: 09/08/2014, 10:22

... 58:371-383. 23. Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A, Mabuchi A, Akiyama F, Tsunoda T, Nakamura Y, Yamamoto K: Analysis of single-nucleotide polymorphisms in Japanese rheumatoid ... to refine the study of effects of modest magnitude and the necessity to replicate studies across different ethnic backgrounds rely on easy access to a large variety of data...

Ngày tải lên: 09/08/2014, 10:23

... chromatin and thereby the DNA is exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects are eliminated by repair enzymes. Poly-(ADP-ribose)-polymerases ... insight into the proportionality between the duration of activation and the increase of fluorescence in- tensity inside of the nuclei of DU145 cells....

Ngày tải lên: 25/10/2012, 11:15

... behavior of LMVs composed of dimyristoylglycerophosphocholine (Myr 2 Gro-PCho), dimy- ristoylglycerophosphoethanolamine (Myr 2 Gro-PEtn) and dimyristoylglycerophosphoglycerol (Myr 2 Gro-PGro) by DSC, ... readily incorporate into Myr 2 Gro-PGro bilayers in the liquid-crystalline state and remain incorporated in the gel state. Permeabilization of phospholipid bilayers by GS ring-size...

Ngày tải lên: 21/02/2014, 01:21

... Zhang,L.,Ahvazi,B.,Szitner,R.,Vrielink,A.&Meighen,E. (1999) Change of nucleotide specificity and enhancement of cat- alytic efficiency in single point mutants of Vibrio harveyi aldehyde dehydrogenase. Biochemistry 38, 11440–11447. 33. ... Deyashiki, Y. , Hara, A. & Mitsui, Y. (1998) Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A ˚ resolut...

Ngày tải lên: 22/02/2014, 04:20

... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... by an increase in PAF biosynthesis via acetylation of 1-alkyl-2-lyso-GPC by acetyl transferase (Fig. 8, f) activity, competition for 1-alkyl-2-lyso-GPC intermediate by variou...

Ngày tải lên: 22/02/2014, 07:20

... mild hyperplasia of the synovial lining, but without any evidence of inflammatory cells being observed (Fig. 5A,B). There were some inflammatory cells in the contralateral synovial lining, but ... could inhibit the mild inflammation induced by intra-articular injection of high doses of adenovirus or the severe inflammation occurring in the AIA model, the levels of white blood le...

Ngày tải lên: 09/08/2014, 01:21