Báo cáo y học: "α Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis" pptx
Báo cáo y học: "α Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis" pptx
... changing, roles in the overall patho-genesis of this form of arthritis. In the light of the findings presented by Kim and colleagues[1], it is interesting that a small number of studies have ... diseaseseverity [5]. In another study, EAE failed to resolve in TNFα-/-or TNFR-/-mice, suggesting that TNFα plays an important role in resolution of inflammation [6]. In murine lupus it was ... have anti-inflammatory proper-ties depending on the timing of TNFα expression in a murinemodel of autoimmune diabetes [9].One possibility to consider is that TNFα acts on cells of thejoint (for...
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Báo cáo y học: "Persistence with anti-tumour necrosis factor therapies in patients with psoriatic arthritis: observational study from the British Society of Rheumatology Biologics Register" pps
... (PsA). TNF acts in the earlystages of the inflammatory process, during which it can stimu-late T-cell activation and induce the expression of IL-2, IFNγreceptors, proinflammatory cytokines (such ... may oftenstop treatment during an infection or elective surgery, anygaps in the use of the same anti-TNF treatment of less than 3months were considered as continuous treatment. Differences in ... cause of drug discontinuation for infliximab was infusion reactions(7.4% of patients receiving infliximab, ~30% of all infliximabdiscontinuations for AEs). Other common reasons for drugdiscontinuation...
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Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf
... structural damage to joints. Preser-vation of joint integrity is closely associated with mainte-nance of functional capability. However, many patientswith early RA are excluded from clinical studies ... space are robust, showing reproducible delineation of synovial thickening in small joints of the hands in patients with active RA, the analysis of such images doesnot necessarily demonstrate a clear ... capable of detecting synovial hyper-aemia in the inflamed RA joint [3,7,11,12] and that signalintensity correlates well with histological assessment of synovial membrane microvascular density [11]....
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... tointerfere with the inflammatory response in SLE by adminis-tering only an induction regime of four infusions of infliximabwithin 10 weeks rather than by planning for long-term therapy.Evidence ... expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus Model [Reference] TNF expression Effects of recombinant TNF Effects of TNF blockade/deficiencyNZB ... Theprimary endpoint is time to reduction in proteinuria below1.5 g/day.ConclusionAlthough our understanding of TNF in SLE has increasedconsiderably over the past few years, novel findings are...
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Báo cáo y học: "New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples" docx
... 58:371-383.23. Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A,Mabuchi A, Akiyama F, Tsunoda T, Nakamura Y, Yamamoto K:Analysis of single-nucleotide polymorphisms in Japaneserheumatoid ... to refine the study of effects of modest magnitude and the necessity to replicate studiesacross different ethnic backgrounds rely on easy access to alarge variety of data organized in a systematic ... estimations than in European ones. Molokhia and McKeigue previously pointedout the difficulty brought up by admixture in investigating theetiology of rheumatic diseases, notably for RA [16]....
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Báo cáo y học: "Positioning Effects of KillerRed inside of Cells correlate with DNA Strand Breaks after Activation with Visible Light"
... chromatin and thereby the DNA is exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects are eliminated by repair enzymes. Poly-(ADP-ribose)-polymerases ... insight into the proportionality between the duration of activation and the increase of fluorescence in- tensity inside of the nuclei of DU145 cells. Figure 2 visualizes the degree of ... protein KillerRed-Lamin B being part of such membranes. Mapping studies of the initial DNA strand breaks in apoptotic Jurkat cells indicated an accumu-lation of single-strand breaks in vulnerable...
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Tài liệu Báo cáo Y học: The effects of ring-size analogs of the antimicrobial peptide gramicidin S on phospholipid bilayer model membranes and on the growth of Acholeplasma laidlawii B ppt
... behavior of LMVs composed of dimyristoylglycerophosphocholine (Myr2Gro-PCho), dimy-ristoylglycerophosphoethanolamine (Myr2Gro-PEtn) anddimyristoylglycerophosphoglycerol (Myr2Gro-PGro) byDSC, ... readily incorporateinto Myr2Gro-PGro bilayers in the liquid-crystalline stateand remain incorporated in the gel state.Permeabilization of phospholipid bilayers by GSring-size analogs In order ... Myr2Gro-PCho, dimyristoylglycerophosphocholine; Myr2Gro-PEtn, dimyristoylglycerophosphoethanolamine;Myr2Gro-PGro, dimyristoylglycerophosphoglycerol; DSC, differential scanning calorimetry; La,...
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Tài liệu Báo cáo Y học: The effects of low pH on the properties of protochlorophyllide oxidoreductase and the organization of prolamellar bodies of maize (Zea mays) pot
... Zhang,L.,Ahvazi,B.,Szitner,R.,Vrielink,A.&Meighen,E.(1999) Change of nucleotide specificity and enhancement of cat-alytic efficiency in single point mutants of Vibrio harveyi aldehydedehydrogenase. Biochemistry 38, 11440–11447.33. ... Deyashiki, Y. , Hara, A.& Mitsui, Y. (1998) Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A˚resolution: the structuralorigin of coenzyme specificity in ... deficiency in organized PLB.The ability of the PLB to form a bicontinuous cubicphase is linked to the high proportion of the nonbilayerforming lipid monogalactosyldiacylglycerol (MGDG) pre-sent in...
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Tài liệu Báo cáo Y học: Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils pot
... synthetase, inhibition of CoA-IT results in anincrease in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... by an increase in PAF biosynthesis viaacetylation of 1-alkyl-2-lyso-GPC by acetyl transferase(Fig. 8, f) activity, competition for 1-alkyl-2-lyso-GPCintermediate by various transferases may ... PAF[55].Thus,whilePLA2isotypes may not be directlyinvolved in generating lyso PAF, the activity of PLA2onPtdEtn may indirectly drive the remodeling process thatgenerates the PAF precursor by providing AA acceptormolecules....
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... mild hyperplasia of the synovial lining, but without anyevidence of inflammatory cells being observed (Fig. 5A,B).There were some inflammatory cells in the contralateralsynovial lining, but ... could inhibit themild inflammation induced by intra-articular injection of high doses of adenovirus or the severe inflammationoccurring in the AIA model, the levels of white bloodleukocytic infiltrate ... initiated in both hind knees of rabbits 3weeks later by the intra-articular injection of 5 mg ovalbu-min dissolved in 0.5 ml Gey’s saline. The different adenovi-ral vectors were injected intra-articularly...
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