Báo cáo y học: "Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet''''''''s disease" potx

... knockdown of HO-1 expression by using specific small interfering RNA resulted in upregula- tion of synthesis of proinflammatory cytokines, including inter- leukin-6, interleukin-8 and TNF, which ... elevated soluble CD 14 in plasma of BD patients may further facilitate LPS binding to TLR4 [36]. Inter- estingly, LPS-induced lung injury in a mouse model was res- cued by adminis...

Ngày tải lên: 09/08/2014, 10:22

... Federation. The extent of osteoarthritis was determined by analyzing plain hand radiographs. The outcome of a principal component analysis of osteoarthritis scores of a total of 28 joints of both hands ... Molecular Medicine, Berlin, Germany 4 Department of Pediatrics, University Medical School Münster, Germany 5 Institute of Medical Genetics, Charité – University Hospitals...

Ngày tải lên: 09/08/2014, 06:23

... rs75286 84) T/T 595 (28.7) 3 24 (30 .4) 45 (36.9) 71 (32.0) 3 24 (30 .4) C/T 1055 (50.9) 5 24 (49 .2) 52 (42 .6) 103 (46 .4) 5 24 (49 .2) C/C 42 3 (20 .4) 217 (20 .4) 25 (20.5) 48 (21.6) 217 (20 .4) P value 0.57 0.69 ... accuracy of genotyping. In addition, for all the assays, genotyping was confirmed in a subset of samples using the Pyrosequencing genotyping method accordin...

Ngày tải lên: 09/08/2014, 08:22

... pretreated with polylysine solution (Sigma Aldrich). After dewaxing and rehydratation, all slides were stained with haematoxylin and eosin. Tissue samples were coded and evaluated blindly by two independent ... deep inspiration. Finally, in a condition of lung hyperinflation, which is often recorded in subjects with emphysema, the ampli- tude of a deep inspiration could be sever...

Ngày tải lên: 12/08/2014, 18:21

... by silver staining on polyacrylamid gel. Statistical Analysis Allele frequencies were determined by gene counting and compared using the א² test. The data was analysed using SPSS 12.0 software. ... coronary lesions were primarily due to the influence of the +T294C SNP. The C allele frequency of 0. 24 in our high risk patient group was similar as the frequency of 0.21 reported b...

Ngày tải lên: 31/10/2012, 17:03

... promotes the folding and assembly of protein by recognizing unfolded polypeptides and inhibiting intra- and intermolecular aggregation [17]. To investigate the role of BiP in the TSHR folding process, ... a glycoprotein consisting of 7 64 amino acids residues inclu- ding a 20 amino acid signal peptide. It has a large extracellular domain consisting of 398 residues, containing six p...

Ngày tải lên: 31/03/2014, 08:20

... leakage induced by intrinsic membrane interaction using purified TRAIL and liposome systems. Release rate of liposome-entrapped dye induced by TRAIL as well as membrane binding ability of TRAIL were ... l M phospholipid) containing calcein at pH 4. 5. The release rate was determined by monitoring the increase in the fluorescence intensity of calcein released from liposomes with excit...

Ngày tải lên: 31/03/2014, 08:20

... for the increased prevalence of T2D have been the target of many studies. Family history, excess of body fat, and physical inactivity have been linked to T2D [4] . Excess of adiposity, specifically ... Weinstein AR, Sesso HD, Lee IM, et al. Relationship of Physical Activity vs Body Mass Index Type 2 Diabetes in Women. JAMA. 20 04; 292: 1188-11 94. 12. Meisinger C, Löwel H,...

Ngày tải lên: 08/08/2014, 16:23

... on stimulation by inflammatory cytokines; they degrade key components of cartilage and bone matrix [6]. MMP1 expression occurs in cells of the invading front of the activated RA synovial tissue ... the SE with the Ratingen score (P = 0. 044 ). The presence or absence of the SE explained 29% of the variance of the Ratingen score, independently of the location at DR4, indi...

Ngày tải lên: 09/08/2014, 01:23

... mecha- nisms with RA and psoriasis, Salvador and coworkers [ 14] examined p53 protein expression in synovial tissue of patients with RA and PsA. They reported differential p53 expression in the synovium of ... participated in study design, and drafted the initial manuscript. LP assisted in gen- otyping some of the control individuals. SH aided in recruit- ment and cli...

Ngày tải lên: 09/08/2014, 07:20