... set the stage for the human genome paper, which was soon to appear.Methods for identifying human genesTo better understand the source of this continuing uncertainty about the gene count, ... sequence in another organism. Together with EST and cDNA alignments, gene finding by homology is the first step in all the major annotation pipelines. But even the most thorough EST sequencing projects ... primate genomes - chimp, macaque, gorilla, gibbon, and orangutan - but in the other primates, the DNA has disabling mutations that disrupt the reading frame. By extrapolating their findings to the...