cd4 cd25 regulatory t cells by self peptides
Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... by converted CD4+ CD25+ T cells Plots were gated on CD4+ CD25+ DCs Dotted histogram lines represent cells stained with isotype-matched control monoclonal antibodies Data represent the mean ± standard ... increase the proportion of antigen-specific CD4+ CD25+ regulatory T cells in tolerized mice Figure shows that the percentage of CD4+ CD25+ cells increased significantly after coculture of CD4+ CD25- T cells ... similar to that in cells cocultured with CD11c+ DCs from CIA mice This result suggests that the conversion into CD4+ CD25+ T cells without CII stimulation result from the IDO-independent expansion...
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Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ" potx
... AAC CTT; Foxp3-RV, TTC TCA CAA CCA GGC CAC TTG; Foxp3-TP, ATC CTA CCC ACT GCT GGC AAA TGG AGT C; TGF-β-FW, TGA CGT CAC TGG AGT TGT ACG G; TGF-β-RV, GGT TCA TGT CAT GGA TGG TGC; TGFβ-TP, TTC AGC ... condition without Treg cells – Radioactivity in condition with Treg cells) /Radioactivity in condition without Treg cells) of the proliferation of Teff cells (CD4+ CD25- ) by increasing numbers of CD4+ CD25+ ... unable to reduce the suppressive effect of wild-type Treg cells against wild-type or IFN-γR KO (data not shown) Teff cells These data demonstrate that the defect in inhibiting CD4+ CD25- Teff cells...
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Báo cáo y học: " Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD" potx
... confirmed in longitudinal studies These data therefore indicate the expansion of a T cell population without a regulatory function, which may contribute to the persistent cytotoxic T cells responses ... supports a potential involvement of the acquired immune response in the pathogenesis of COPD To further evaluate the role of regulatory T cells in COPD and to clarify whether CD4 + CD25 bright cells ... the upregulation of regulatory T cells would restrain cigarette smoke-induced inflammatory activation and, thus, the development of COPD [10] In contrast, in smokers who develop COPD, the T regulatory...
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báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx
... Biosciences) The reactivity of CD8+ T cells to WT1 or CEA or both are shown as the percentage of the total population of CD8+ T cells that were double positive (CD8+pentamer+) Cytotoxicity assays The cytotoxicity ... [36,37] The fusion cells could prime naive T cells to differentiate into CTL with lytic activity against the HCC cells (Figure 3A and 3B) After hr coculture of the HCC cells with healthy donor's T cells ... In contrast, autologous DCs or the HCC cells were not able to stimulate the T cells (Figure 6A) We next examined the quality of CD4+ and CD8+ T cells from the HCC patient vaccinated by autologous...
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Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx
... report that the effective function of the CD4+ CD25+ regulatory T cells is T- cell receptor (TCR) specific [28] Collectively, our data suggest that the CD4+ CD25+ regulatory T cells may not be involved ... autoimmune gastritis It has been shown that the CD4+ CD25+ regulatory T cells express CTLA-4 [6–8], which is a negative regulator of T- cell activation The suppressive activity of the CD4+ CD25+ regulatory ... mediate the induction of the disease CD4+ CD25+ regulatory T cells may not control autoimmune arthritis To further investigate whether the CD4+ CD25+ T cells play a role in PGIA, we performed adoptive...
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Báo cáo y học: "The relationship between CD4+CD25+CD127regulatory T cells and inflammatory response and outcome during shock states" potx
... between patients and healthy volunteers throughout the study period, patients with shock presented with constantly decreased NK absolute To get further insight in to the role of Tregs during septic ... to deplete Tregs, we must acknowledge that anti -CD25 is not specific for Tregs and leads to the depletion of other important cells (activated T cells) Moreover, anti -CD25 antibody may not have ... severity and cytokines plasma concentrations Considering the correlation between Tregs and outcome, at least in septic patients, we evaluated the relation between these cells and severity Indeed, there...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... doubly transgenic mouse have also demonstrated that the CD25 +CD4+ TR cells show a high self- reactivity and differentiate on thymic epithelial cells [41,42] Thus, the central generation of CD25 +CD4+ ... showed that the adoptive transfer of CD25- depleted thymocytes to syngeneic nude mice recipients led to a similar spectrum of autoimmune disease to that with CD25 CD4+ peripheral cells [14] CD25 +CD4+ ... CD25 +CD4+ TR cells is dependent on relatively high-avidity TCR interactions with self- peptide/MHC complexes within the thymic stroma However, it is still not clear why the relatively self- reactive TR...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... against the foreign antigen mBSA clearly demonstrates that their suppressive effect is not strictly limited to autoreactive T cells Taking into consideration that Treg cells are also critically ... injected with rat IgG (Fig 1) Of note, the antiCD25 treatment almost completely depleted cells with high expression of CD25, which are considered Treg cells, in contrast to CD4+ T cells with low ... online http://arthritis-research.com/content/7/2/R291 Figure Transfer of regulatory T cells (Treg cells) cannot cure established arthriarthritis tis Pre-activated CD4+ CD25+ cells (1 × 106) were transferred...
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Báo cáo y học: "Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells" doc
... in CD4+ CD25- T cells It is also important to note that, although the CD25low population lies adjacent to CD25- on a FACS plot (as shown in Figure 2), they belong to two different cell entities ... patients correlated with disease activity and that the cell number significantly decreased after glucocorticoid treatment [2] Whether these cells are Tregs or activated Teffs remains to be determined ... with untreated new-onset lupus (UNOL) (UNOL) intracellular Foxp3 in CD4+ CD25- T cells and that CD4+ CD25- CD127low/- T cells could not be used as a live substitute for CD4+ CD25- Foxp3+ T cells to...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... Cytotoxicity of In Vivo Generated T Cells T2 -cytotoxicity Cumulative cytotoxicity results for all patient samples show that after two cycles of vaccination (the time point associated with the ... substantial generation of tetramer+, CD8+, T cells In fact, the responses generated to the two DC preparations were atypical only in this particular patient The remaining patients showed the pattern ... that hTERT p540 is not expressed or is cryptic on the surface of tumour cells and that immunization of cancer patients with hTERT p540 leads to the production of T cells that not recognize tumour...
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Báo cáo hóa học: " Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients" pdf
... exported from thymus to the periphery within recent thymic emigrants (RTEs), therefore, the frequency of sjTRECs is considered to be the most accurate marker of T- cell neogenesis Quantitative detection ... in the T- A acceptor site and subsequently the sjTREC was cloned in to the EcoRV restriction site of the TOPO TA Vector (Invitrogen, Groning, The Netherlands) Based on the DNA concentration, measured ... doesn 't allow the evaluation of the complexity of thymic output in different TRBV subfamily naïve T cells, which is an important factor in immune competence In this study, we analyzed the total...
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Báo cáo sinh học: "Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" pot
... preventing recognition by cytotoxic T cells Antibodies on the other hand retain their ability to recognize native antigens but in case of tumors their potential effects are compromised by their ... that is not dependent on MHC-1-associated peptide presentation *LCK is a lipid raft-associated protein that phosphorylates ITAMs of the TCR zeta chain, allowing them to bind the zeta associated ... documented against only a restricted number of tumor types and this approach to cancer therapy has been further restricted by toxicity associated with the need for exogenous administration of interleukin-2...
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báo cáo hóa học:" Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" docx
... preventing recognition by cytotoxic T cells Antibodies on the other hand retain their ability to recognize native antigens but in case of tumors their potential effects are compromised by their ... that is not dependent on MHC-1-associated peptide presentation *LCK is a lipid raft-associated protein that phosphorylates ITAMs of the TCR zeta chain, allowing them to bind the zeta associated ... documented against only a restricted number of tumor types and this approach to cancer therapy has been further restricted by toxicity associated with the need for exogenous administration of interleukin-2...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... Ozdemir et al, Regulatory T Cells in the Context of Allergic Disease The mechanisms by which SIT has its effects include the very early desensitization effect The regulation of Tcell responses by generation ... mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated oral LCs expressed ... Treg cells, account for to 10% of peripheral CD4+ T cells and inhibit the activation of effector T cells in the periphery.38,39 FOXP3, the transcriptional regulator expressed on Treg cells, acts...
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Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx
... joint These features were apparent in the vast majority of the patients despite the different treatments they received, indicating that the anti-rheumatic drugs that patients receive not affect the ... enrichment of regulatory T cells was seen Thus, the simple extrapolation of the animal data into future therapeutic strategies that aim at reconstituting this population does not seem to hold true ... JIA it has been reported that T cells in synovial fluid are not in active cell cycle [28] This study is the first to demonstrate that CD25brightCD4+ T cells from patients with spondyloarthropathies,...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... It is thought that TR cells in mice represent those thymocytes with the highest affinity for self- peptide but that are below the threshold of negative selection [50] Only a small number of TR ... by activation of CD4+ CD25 T cells with mature, allogeneic dendritic cells, and these T cells also expressed FoxP3 The specificity of the TR cells was determined by the type of mature dendritic ... and CD25 In this way, activation itself would lead to a limitation of the extent to which the T- cell response could proceed It is not yet known whether the CD4+ CD25 T cells capable of differentiating...
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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... activation of CD4+ CD25+ cells is antigen specific, once these cells are activated they not only suppress T cells stimulated by the same antigen, but they also inhibit T cells stimulated by other ... Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes Characterization of the CD4+ T cell subset that inhibits this autoimmune potential J Exp ... T- lymphocyte activity by preventing the activation of CD8+ cells [14] Other workers have also reported that CD4+ CD25+ cells have potent suppressive effects on CD8+ cells Rodent CD4+ CD25+ regulatory cells...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... population of Treg and documentation of their in vivo potential was an important next step In pursuit of this goal, recent studies demonstrated for the first time that the transfer of in vitro ... in the absence of TGF-β and/or if TGF-β is dysregulated The identification and intersection points of such pathways await further study Among the factors that contribute to the regulation of TGF-β ... abnormalities have been attributed, at least partly, to defective production and function of TGF-β [12,66] In contrast to strong suspicions, few data yet exist as to whether the uncontrolled T and...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... before treatment with anti-TNF-α were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes After anti-TNF-α treatment the ‘hibernated’ peripheral blood CD4+ CD25+ ... all these studies CD4+ CD25+ Treg were detected in the joints or synovial fluid of the patients In these reports it was also shown that the identified CD4+ CD25+ Treg had a suppressive function ... might not be a feasible option treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... cells that positively correlated with disease activity, and the suppressive function of these cells was intact in cultures without antigen-presenting cells The functional activity of both patient ... correlated with disease activity Although this group attributed this resistance to decreased sensitivity of responder T cells to suppression, they did not exclude the possibility that excessive costimulation ... overcome the strength of T- cell stimulation or the inhibitory effects of proinflammatory cytokines produced by other cells It is known that strong Toll-like receptor stimulation triggered by microbial...
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