Báo cáo y học: "Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study" docx

... membrane analysis of synovial fibroblast supernatantsProteomic membrane analysis of synovial fibroblast supernatants. (a) Comprehensive protein membrane array map. The human protein array simulta- neously ... sensitivity of the protein mem- brane array is very high for CXCL8, ranging from 1 to 25 pg/ ml and it thus detects even very small amounts of protein. The secretion of inflamm...

Ngày tải lên: 09/08/2014, 10:22

... PKA regulatory domains contain an alanine residue while protein kinases G contain serine or threonine. The hydroxyl side chain of either one of these residues interacts with the C2 amino group of ... Unexpectedly, one absolutely conserved arginine residue in each of the two domains is replaced by Thr318 and Asn442 in TbRSU. In the bovine regulatory subunit, and by inferenc...

Ngày tải lên: 31/03/2014, 23:20

... specific in this respect. Sensitivities ranged from 64% for assay of Abs against teichoic acid to 72% for assays of antibody to peptidoglycan and α-toxin. The specificity of assays for antibody ... human pathogen causing significant morbidity and mortality in both community and hospital acquired infections [1]. It causes a diverse array of infections ranging from relatively...

Ngày tải lên: 02/11/2012, 11:08

... aromatic amino acid hydroxy- lases [1], catalyzes the conversion of L -tryptophan to 5-hydroxy- L -tryptophan. This reaction is the initial and rate-limiting step in the biosynthesis of serotonin [2–5]. ... Press Inc., New York and London. 2. Hosoda, S. & Glick, D. (1965) Biosynthesis of 5-hydro- xytryptophan and 5-hydroxytryptamine from tryptophan by neoplastic mouse mast cells....

Ngày tải lên: 08/03/2014, 16:20

... cannot stay still for long' and 'I am constantly fidgeting or squirming'. These findings indicated that the aforementioned items create a subdimension within the hyperactivity/inatten- tion ... Modeling 1999, 6:1-55. 39. Nunnally JC, Bernstein IR: Psychometric theory. New York, USA: McGraw-Hill Book Company; 1994. Annals of General Psychiatry 2009, 8:20 http://www.annals-gen...

Ngày tải lên: 08/08/2014, 23:21

... mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4 + cells to the inflamed joints. Here, we investigated whether AMD3100 can likewise ... entry into CD4 + human lymphocytes [4]. Like other members of the chemokine family, CXCL12 may play a role in inflammatory dis- eases. Specifically, there is increasing evidence that C...

Ngày tải lên: 09/08/2014, 07:20

... coordination of the study and the clinical follow-up. SP participated in the coordination of the study and performed CDS. M Kanakis helped in the clinical fol- low-up and in the analysis and interpretation ... the combined analysis of any kind of abnormality found in CDS in patients with clinically sus- pected GCA, including perfusion and blood-flow abnormali- ties, and the...

Ngày tải lên: 09/08/2014, 08:22

... of the inflamma- tory environment in OA cartilage on the transplanted chondro- cytes. Cytokines, including IL-1 and TNF-α, are secreted by OA cartilage. Such cytokines are known to induce cartilage degradation ... potential of human OA chondrocytes using microarray technology in order to deter- mine whether OA chondrocytes might possibly be used in second-generation ACT. Microa...

Ngày tải lên: 09/08/2014, 14:22

... as a way to maintain the immunologic and clinical benefit of therapy while reducing drug-toxicity and drug- costs [4]. Despite continued concerns over the safety of interrupting therapy, a large ... an increase in CSF and plasma HIV RNA after stopping therapy, accompanied by intrathecal immunoactivation as evidenced by CSF lymphocytic pleocytosis (7/8 patients) and increased CSF neopt...

Ngày tải lên: 10/08/2014, 05:20

... is an altera- tion in leptin binding proteins by ritonavir. Ritonavir may regulate serum binding proteins or the soluble leptin receptor. These binding proteins affect the stability, deliv- erance ... Kimberly F Allred, Elizabeth M Kordik, Deana K Jasper, Amanda N Rosewell and Anthony J Bisotti Address: Department of Physiology, College of Medicine, University of Kentucky, Lexingto...

Ngày tải lên: 10/08/2014, 05:20