Báo cáo khoa học: " Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation" pot

... Access Review Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given ... : Report of an IAEA meeting. Int J Radiat Oncol Biol Phys 2006, 64:551-561. 54. Bohm L: Inhibition of homologous recombination...

Ngày tải lên: 09/08/2014, 10:20

... were visualized by autoradiography of dried gels. Specificity of binding to IRP-1 was demonstrated by competition with unlabeled ATP, ATP-cS, and unlabeled 8-azido- ATP, and by lack of competition with the ... activity of IRP-1 is also enhanced in the presence of IRE, we measured hydrolysis of [ 32 P]ATP[cP] in the presence of 0–400 ng of IRE (Fig. 8). Compa...

Ngày tải lên: 07/03/2014, 09:20

... respectively. The PDB code for the wild-type protein is 2E4L. For the entire structure (A), N and C represent the N- and C-termini of the protein, and a and b represent the a helix and b strand, respectively. ... together with the distances. For the structure around residue 39 (C), the side-chains of Y24, residue 39, F41 and Q149 are shown. The hydrogen b...

Ngày tải lên: 18/02/2014, 13:20

... likely, the mature part of r pro-Der p 1 is not ef®ciently substituted with 125 I in the presence of the propeptide, in contrast with the recombinant mature Der p 1 after removal of the p ropeptide. In ... Both the lack of enzymatic activity and the hypoallergenic character make this recombinant a potential safe candidate for a pplication in allergen-speci®c immu...

Ngày tải lên: 17/03/2014, 11:20

... 3 h of chase, only 25% of trun- cated pFGE were retained within the cells (Fig. 4B). On the contrary, very little of the wild-type and the KDEL form of pFGE was secreted during the pulse, and ... were loaded at a ratio of 10 : 1. The amount of total pFGE in cells and medium and the percentage of intracellular pFGE are given below the lanes. Two diff...

Ngày tải lên: 23/03/2014, 07:20

... inhibition of each of the tested compounds. These data were then compared with the experimentally determined data (percentage inhibition at 100 lm), and the results are presented in Fig. 8. The ... that the presence of a nitro group at the 5-position was associ- ated with stronger inhibition (1c compared with 1d; 1h with 1i) and this was positively associat...

Ngày tải lên: 19/02/2014, 05:20

... FEBS 373 Thermal unfolding transition in the absence and in the presence of the different ligands The influence of ligand binding on the thermal stability of C-LytA was studied by monitoring the CD ... in the separ- ation of the daughter cells at the end of cell division and in cellular autolysis [9], where it mediates the release of toxins that damage...

Ngày tải lên: 19/02/2014, 05:20

... 2B). The addition of 20 l M Zn-ferrocyanide in the reaction medium from the beginning of the measurement leads to the appearance of the reduced form of the enzyme, even in the presence of the ... together, these results may support the idea that the flavin itself may be involved in the interaction of the flavoproteins with the metal. The kinetic analy...

Ngày tải lên: 19/02/2014, 16:20

... inactivation of G APDH being metal- ion independent, whereas inhibition of GR and LDH by H 2 O 2 occurs most rapidly in the presence of metal ions. It is proposed that the inhibition of GAPDH and GR by these 1 O 2 -generated ... supported by the inefficient inhibition of LDH by these peroxides, in the absence of metal ions, as this enzyme does not contai...

Ngày tải lên: 21/02/2014, 03:20

... tumor cells exhibiting IR; 1, < 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cells exhibiting ... characteristics and specific immunoreactivity (IR). The staining was semi- quantitatively evaluated by assigning a score for the inten- sity of the IR...

Ngày tải lên: 07/03/2014, 03:20