Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx

... article Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus Michael Mahler 1 , Aderajew Waka 2 , F Hiepe 3 and Marvin J Fritzler 4 1 Development ... which may result in the detection of anti- dsDNA antibodies in the SmD peptide ELISA [32]. In the present study we confirmed the d...

Ngày tải lên: 09/08/2014, 10:20

... sequences of MREa function in sequence-specific interaction with the HepG2 nuclear proteins. Characterization and purification of MREa -binding factors To determine the molecular mass of the MREa -binding proteins, ... cysteine-rich, metal -binding proteins that function in the maintenance of metal homeostasis and detoxification by forming strong complexes with several t...

Ngày tải lên: 17/03/2014, 23:20

... Once in the vicinity of the synovium, the DPPIV activity would be able to initiate amino-terminal degradation of the increased levels of pro- inflammatory neuropeptides, cytokines and chemokines ... finding in RA, although not consistently observed in the synovial fluid (Table 1). Despite the inconsistency in reporting of differing DPPIV levels between non-inflam...

Ngày tải lên: 09/08/2014, 07:20

... damage by injection of interleukin-1 (IL-1) into murine knee joints. After 2 days, we injected an adenovirus encoding TGFβ. On day 4, we measured proteoglycan (PG) synthesis and content. To examine ... On day 2, an aden- ovirus encoding active TGF-β was injected into the knee joint. The TGF-β overexpression boosted the incorporation of 35 SO 4 2- beyond the already elevated...

Ngày tải lên: 09/08/2014, 07:20

... the discovery of the sprouty protein family as ras inhibitors, induced by ras itself, contributes to the seemingly ever increasing complexity of ras signal modulating mechanisms. In view of the ... representation of hspry4 and TESK1 proteins, which interact in yeast two-hybrid assay. The hspry4 protein, fused to the GAL4 DNA binding domain (BD), contains three po...

Ngày tải lên: 31/03/2014, 15:20

... hyperplasia of the intimal lining layer and cell infiltration of the synovial sublining were detected and a decrease in bone erosions was observed. (b) Infiltration of inflammatory cells of the joints ... shown). IFN- ββ modulates the cytokine profile in inflamed synovial tissue. To provide more insight into the mechanism by which IFN- β therapy exerts its beneficial e...

Ngày tải lên: 09/08/2014, 01:23

... allowing the detection of cytokines without any BALF manipulation that could influence the stability of cytokines. By using this technique, we observed abnormalities in a broad range of cytokines ... differentiated into lymphocytic, neutrophilic, eosinophilic, and mixed forms (combination of lymphocytosis and granulocytosis). Bioplex analysis Cytokine concentrations adjusted acc...

Ngày tải lên: 09/08/2014, 14:22

... connection may borrow tokens from the bank. The priority of a connection in borrowing tokens from the bank is determined by the priority index (P i ), given by P i = E i r i . (1) By prioritizing in ... modeled by considering the effect of intercell interference and intracell interference on the sector of interest in the central cell (denoted as sector 1 in BS 1)....

Ngày tải lên: 21/06/2014, 23:20

... retinal, kinetics of the inhibition of xCTBP/xALDH1 by T 3 was examined by variation of NAD + concentration within the reaction mixture. The K m value, 9 l M , was independent of the concentration of ... for cytosolic retinoic acid and retinol binding proteins where it has been suggested that these binding proteins may act, not only as buffers or reservoirs of intracel...

Ngày tải lên: 31/03/2014, 21:21

... measurements The analysis of the CD34 positive cells was per- formed by adopting the gating strategy defined by the International Society of Haematotherapy and Graft Engineering (ISHAGE) guidelines ... study resulted in the improvement of the number of CD34+ cells in circulation and the decrease of the values of cardiovascular risk factors. According to ou...

Ngày tải lên: 25/10/2012, 10:51