the environment in the pathogenesis of systemic lupus erythematosus 2
Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx
... SLE 3.7 32. 50 25 427 SLE 26 .2 200 25 429 SLE 2. 4 40.6 25 431 SLE 2. 0 27 .2 25433 SLE 179.0 20 0 25 434 SLE 3.4 26 .4 25 435 SLE 6.5 41.7 25 437 SLE 2. 6 64.7 25 441 SLE 40.4 20 0 25 4 42 SLE 3.0 37.8 25 443 SLE ... 126 127 1.0 0.6 17.2b 0.5b 1.8 Positive 27 224 26 5 607 7.8 4.5 190.1 88 .2 2.9 Positive 27 960 165 326 7.8 5.7 1 82. 5 23 .2 3.3 Positive 28 077 25 0 527 9.0 5.6 1 82. 0 73.7 4.8 Positive 28 2 42 65 1 02 ... 37.7 25 494 RA 2. 4 28 .7 25 495 RA 1 .2 29.7 25 501 RA 2. 4 51.1 25 510 RA 3.4 29 .2 25513 PM/Scl 3.1 43.8 25 516 MCTD 3.8 32. 3 25 517 PM/Scl 1.3 94.9 25 528 Scl 3.3 30.5 25 529 Overlap syndrome 4.1 63.4 25 530...
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Báo cáo y học: "Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden" potx
... sampling 50.1 (40 .2, 52. 3) 50 .2 (49 .2, 60.1) 24 .7 (21 .7, 29 .0) Median age at symptom onset Median age at diagnosis 52. 0 (46.8, 61 .2) 53.5 (48.0, 62. 7) 52. 3 (51.0, 62. 1) 52. 8 (51.1, 63.1) 31.7 (26 .5,39.1) ... background of the different patient cohorts All of the individuals included in the present study were from northern Sweden, whilst in the two other studies cited [3 ,20 ], 62% were black in both studies, ... supply of the blood samples SRD designed the study, analysed and interpreted the data and was involved in drafting the manuscript All authors have given their final approval of the version of the...
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Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... transmembrane prolyl 4-hydroxylase is induced by hypoxia 21 22 23 24 25 26 27 28 29 30 31 32 33 34 and acts on hypoxia-inducible factor alpha J Biol Chem 20 07, 28 2:30544-305 52 Jeong JW, Bae MK, Ahn MY, ... patient about 20 0 single measurements of PO2 were taken at a predefined area on the dorsal forearm, and an individual PO2 mean value was determined Average PO2 in the skin of healthy individuals ... binds directly to the ODDD of HIF-1α in the cytoplasm and acetylates a single lysine residue at position 5 32 Acetylation of this specific lysine residue favours the interaction of HIF-1α and the...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... administered during the most active stage of disease [29 ] The discrepancy between the two studies could be due to a number of factors, including the longevity of the injected protein and the level of free ... autoantibody-inducing T cells of lupus J Exp Med 1993, 177:1367-1381 Gardner WD, Hoch SO: Binding specificity of the two major DNA-binding proteins in human serum J Biol Chem 1979, 25 4: 523 8- 524 2 Tolun ... was mainly measured from urine instead of serum because the absence in urine of natural inhibitors of DNase activity such as G-actin To test if the expression of DNase I from T cells in the transgenic...
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Báo cáo y học: "Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus" pps
... (rs1799931) These four SNPs yield six haplotypes in the NAT2 gene in the Japanese population, namely NAT2*4, NAT2*5B, NAT2*5E, NAT2*6A, NAT2*7B and NAT2*13 Of these, NAT2*4 is the wild-type haplotype; the ... Talal N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 : 127 1- 127 7 20 Hochberg MC: Updating the American College of Rheumatology ... NAT2*4/*4 Fast 15 21 NAT2*4/*5B Fast 2 NAT2*4/*5E Fast 1 NAT2*4/*6A Fast 12 17 NAT2*4/*7B Fast 13 (27 .7) 34 ( 72. 3) 47 Fast acetylators NAT2*6A/*6A Slow 1 NAT2*6A/*7B Slow NAT2*7B/*7B Slow 1 2 (28 .6)...
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Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc
... Sánchez-Tapias JM, Ingelmo M: Hepatitis C virus infection mimicking systemic lupus erythematosus: study of hepatitis C virus infection in a series of 134 Spanish patients with systemic lupus erythematosus ... problem of increasing clinical significance Interferon (INF) therapy is the mainstay of HCV treatment HCV and HIV have been associated with the development of autoimmune markers and disease; INF therapy ... following anti-TNF therapy or by increased IFNa In coinfected patients, the risk of development of SLE associated with INFa HCV therapy, HCV is significantly reduced by the concomitant HIV infection...
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Báo cáo y học: " Dissemination of Strongyloides stercoralis in a patient with systemic lupus erythematosus after initiation of albendazole: a case report" docx
... occur several days into appropriate antihelminth therapy and should remain vigilant for signs of sepsis even during the early days of therapy Our findings are based on a single case report, and ... corticosteroid administration for this disease [8] Dissemination may involve gut, stomach, lung and/or cerebrospinal fluid [9,10] Furthermore, larval penetration of the intestinal wall during dissemination ... testing by enzyme-linked immunoassay further confirmed the diagnosis Treatment with oral albendazole (400 mg twice daily) was initiated within 20 hours of presentation; however, the patient continued...
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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx
... profiles of SLE BB % (ratio) n = Bb % (ratio) n = 22 bb % (ratio) n = 77 Total % (ratio) Malar rash 50 (1 /2) 54.54 ( 12/ 22) 54.54 ( 42/ 77) 54.45 (55/101) Discoid rash (0 /2) 27 .27 (6 /22 ) 31.16 (24 /77) ... (24 /77) 29 .70 (30/101) Photosensitivity 50 (1 /2) 31.81 (7 /22 ) 38.96 (30/77) 37. 62 (38/101) Oral ulcer 50 (1 /2) 31.81 (7 /22 ) 36.36 (28 /77) 35.64 (36/101) Arthritis 100 (2/ 2) 77 .27 (17 /22 ) 70. 12 (54/77) ... (5/77) 7. 92 (8/101) Renal disorder 50 (1 /2) 68.18 (15 /22 ) 64.93 (50/77) 65.34 (66/101) Neurologic disorder (0 /2) 9.09 (2/ 22) 20 .77(16/77) 17. 82 (18/101) - Seizure (0 /2) 9.09 (2/ 22) 15.58 ( 12/ 77)...
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Báo cáo y học: "Culture-negative bivalvular endocarditis with myocardial destruction in a patient with systemic lupus erythematosus: a case report." ppsx
... Truant, PhD for their gracious assistance in this case Authors’ contributions BRL participated in the care of the patient and wrote the initial manuscript BS participated in the care of the patient ... and edited the manuscript All authors participated in approving the final manuscript Competing interests The authors declare that they have no competing interests Received: April 20 11 Accepted: ... systematic serological testing in diagnosis of infective endocarditis Journal of Clinical Microbiology 20 05, 43: 523 8- 524 2 Laurence and Suh Journal of Cardiothoracic Surgery 20 11, 6:109 http://www.cardiothoracicsurgery.org/content/6/1/109...
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Báo cáo y học: " Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report" ppt
... germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report Journal of Medical Case Reports 20 10 4:97 Figure An image of our patient’s pituitary showing polymorphic cells ... advantage of: Authors’ contributions All the authors contributed to the management of the patient Additionally, MS was the primary author of the manuscript All authors read and approved the final ... to the pituitary involvement and its effect on her ovaries At the same time, her SLE was also in remission This can be explained by the fact that the reduction in immunoregulatory functions of...
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Báo cáo y học: "Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study" potx
... 40 (37.9-43.8) 42. 8 (40-46.9) 0.33 Aspartate aminotransferase, IU/L 23 (19 -26 ) 23 (17.5 -24 .5) 28 (20 -33) 0 .26 Alanine aminotransferase, IU/L 22 (15 -29 ) 19 (13 -24 .5) 25 (19-37) 0 .21 γ-Glutamyltransferase, ... hours (2- 3) 2. 3 (2- 3) 1.3 (1 -2) 0.01 C 12 h, mg/L 32. 1 (24 .3-41.9) 34.7 (26 .4-49 .2) 29 .8 (15.5-40) 0 .26 MPAG/MPA AUC0- 12 h ratio 11.5 (8.3 -20 .7) 10.9 (6 .2- 14.8) 18.7 (14.1 -22 .7) 0.07 MPAG/MPA C 12 h ... γ-Glutamyltransferase, IU/L 24 (17-63) 23 (17 -21 ) 42 (17-61) 0. 92 (2- 2) (2- 2) (2- 2) 0.9 Corticosteroids, mg/day 11 (7-35) 10 (5 -20 ) 15 (7-45) 0.37 Months of MMF therapy (1-3) (1-3) (1-3) 0.56 Months of corticosteroids...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... role in T cell dysregulation in SLE [19 -21 ] Activation-induced rapid Ca2+ signals are higher in T cells from patients with SLE [22 ]; in contrast, the sustained Ca2+ signal is decreased in these lupus ... of IL-12R 2 via cGMP Together, these data indicate that NO has a crucial role in the regulation of Th1/Th2 polarization Nitric oxide regulates T lymphocyte activation in systemic lupus erythematosus ... the TCR ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ fluxing The potential role of NO in the regulation of FcR gamma expression clearly needs further...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... VH3-74* 02 VH5-51 3-10*01 2- 21* 02 1 -26 *01 3 -22 *01 5* 02 4* 02 5* 02 4* 02 2-15*01 3-10 6* 02 4* 02 1 -26 *01 VH2-5* 02 VH3 -21 *01 VH3-30*03 2- 8*01 VH3-30*03 2- 8*01 VH3-30.3*01 3-3*01 VH4-30.1 2- 2*01 5*01 VH2-5* 02 ... 4-4*01 5* 02 B C D VH3-07 VH3 -23 VH3-33 VH3- 72* 01 VH4-59* 02 VH5-51*01 VH5-51*01 2- 15 3 -22 6-13*01 5-5*01 5 -24 *01 2- 2*01 6-13*01 6* 02 4* 02 6* 02 4* 02 3 1 1 4* 02 6* 02 5* 02 4* 02 4* 02 4* 02 3* 02 2(1) 1 ... VH3 -23 VH5-51-D2 -2 VH4-30 2. 9 4.5 2. 7 23 .5 3 2. 4 22 3 .2 3:0 6 6.4 4.6 R/S ratio of all sequences VH3-07 VH3 -23 VH5-51 2. 4 4.5 2. 75 2. 9 1.7 3.5 2. 9 2: 0 3:0 R/S of all clones 2. 8 2. 1 i 12 R/S of...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... Hs0 020 2 721 _m1 Interferon, alpha-inducible protein (IFI6) Hs0 024 2571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs0019 426 1_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs0 027 1467_m1 Interferon, ... N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 : 127 1- 127 7 Gladman DD, Ibanez D, Urowitz MB: Systemic lupus erythematosus ... signatures in systemic lupus erythematosus blood J Exp Med 20 03, 197:711- 723 Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY: Analysis of gene expression profiles in human systemic lupus erythematosus using...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... accelerated atherosclerosis in SLE has changed our management of the disorder Lupus 20 00, 9 :22 8 -23 1 Lockshin MD, Salmon JE, Roman MJ: Atherosclerosis and lupus: a work in progress Arthritis Rheum 20 01, ... 44 :22 15 -22 17 Giri S, Parke AL, Waters DD: Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42- 52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The ... induced in it by corticosteroid therapy A study of 36 necropsy patients Am J Med 1975, 58: 24 3 -26 4 Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: ...
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Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility" pptx
... be involved in the pathogenesis of SLE, could further elucidate the genetic basis of the disease In the present study we found that the combination of the FcγRIIa R/R genotype with the IL-1Ra 2/ 2 ... classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 : 127 1- 127 7 16 Jonsson H, Nived O, Sturfelt G: Outcome in systemic lupus erythematosus: a prospective study of patients from a defined ... not increase susceptibility to the disease This finding illustrates that combinations of polymorphic genes may act in concert in the pathogenesis of SLE, a concept that may be instrumental in the...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... and then soaked in balanced salt solution (Sigma) for 30 at 25 °C Cells were then incubated for 30 at 25 °C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and 0 .2% ... Tween -20 ) Apoptosis was evaluated by propidium iodide staining, according to the method of Nicoletti and colleagues [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding ... participated in the design of the study and in the revision of the manuscript EP participated in analysis of data GV participated in the design and revision of the study EO conceived of the study,...
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Báo cáo y học: " Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population" doc
... cHaplotype consisting of markers rs2004640 (G > T) and rs 228 0714 (T > C) gains in narrowing the disease associated interval owing to different patterns of linkage disequilibrium In this study of a Korean ... 0.38 25 4 28 4 0.56 22 4 Cases 725 879 0.61 571 0.39 1,434 1,467 0.51 1401 480 595 0. 62 365 0.38 25 6 26 6 0. 52 246 137 0.63 81 0.37 Controls 121 116 0.48 126 Cases 2, 839 3,193 0.56 2, 485 1.85 × 10 -23 ... with systemic lupus erythematosus Am J Hum Genet 20 05, 76: 528 -537 Hochberg MC: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction regime of ... blockade in patients with systemic lupus erythematosus While dampening inflammation, TNF blockade with infliximab induced an increase of autoantibodies in five out of seven patients and increases in ... regulation of the two cytokines is not functional in active SLE Rather, the combined increase of both TNF and IFN-α might contribute to the pathogenesis of systemic autoimmunity Another hypothesis...
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