... joint involving macrophages, T and Blymphocytes, and synovial fibroblasts. Laboratory investi-gations in vitro and in vivo have resulted in new findingsabout the role of the chondrocyte in ... highexpression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial microvessels, and in cartilage adjacent to inflam-matory tissue [185]. ... cell interactions involving T and Blymphocytes, monocyte/macrophages, and dendritic cells, several different cytokines are produced in the inflamed synovium as a result of the influxof inflammatory...