Báo cáo y học: "Inflammatory cells and bone loss in rheumatoid arthritis" doc

... RANK, by these cells could provide a large, transient increase in RANKL levels in the joint, supplementing that normally provided by the chronic inflammatory cells in synovial tissues. This may result ... many factors that are also released by macrophages, lymphocytes and fibroblasts indicates that they can play similar roles in chronic inflammation. Many of these factors are pi...

Ngày tải lên: 09/08/2014, 10:20

... oedema actually means in RA. The implications are exciting and suggest a new focus for understanding disease pathology and influencing disease progression; moving away from the synovium and towards the bone ... role of bone marrow-derived stem cells in trafficking to the subchondral bone and synovial membrane in rheumatoid arthritis joints, resulting in a subchondral...

Ngày tải lên: 09/08/2014, 08:23

... be involved in the induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presenting cells in rheumatoid arthritis B cells actively participate in ... approach than targeting a single cytokine or chemokine. The role played by B cells in the maintenance of ectopic germinal centre-like structures, as well as in the immune respo...

Ngày tải lên: 09/08/2014, 10:20

... also abundant in the synovial lining and sublining layers of the synovium associated with CCL20 (MIP-3α)-expressing cells, as well as in rheumatoid nodules and the synovial fluid. In synovial tissue the ... http://arthritis-research.com/content/9/4/219 Abstract Dendritic cells are the major antigen-presenting and antigen- priming cells of the immune system. We review the an...

Ngày tải lên: 09/08/2014, 10:20

... joint involving macrophages, T and B lymphocytes, and synovial fibroblasts. Laboratory investi- gations in vitro and in vivo have resulted in new findings about the role of the chondrocyte in ... high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial microvessels, and in cartilage adjace...

Ngày tải lên: 09/08/2014, 10:21

... antigen presentation in monocytes and inhibits the production of pro- inflammatory cytokines, GM-CSF, and Fc-γ receptors by synovial Mφ. Consistently with cytokine and chemokine downregulation, IL-10 clearly suppresses ... rheumatoid arthritis Cytokines with a dual role are indicated in Tables 4 and 5. Interleukin-6 IL-6 is the most strikingly elevated cytokine in RA, especial...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... SF inflammatory mediators, MMP activity and cartilage biomarkers in healthy joints. In short, prostaglandin E 2 , substance P, bradykinin and MMP activity rise shortly after induction of inflammation; ... horses and a transient inflammatory stimulus may limit Figure 2 Synovial fluid inflammatory mediators and matrix metalloproteinase activity in inflamed jointsSynovial fluid inf...

Ngày tải lên: 09/08/2014, 13:22

... that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhibited conditions, including irradiation, serum depletion and high cellular density. Surprisingly, they showed ... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin a...

Ngày tải lên: 09/08/2014, 06:22

... may be useful for inhibiting bone destruction in a variety of pathological bone diseases. Inhibitory cytokines produced by T cells on osteoclast differentiation We previously reported that bone- marrow-derived ... [57,58] recently demonstrated that estrogen deficiency induces bone loss by enhancing TNF-α production by T cells. Ovariectomy failed to induce bone loss in T-ce...

Ngày tải lên: 09/08/2014, 06:22