Báo cáo y học: "B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue" doc

... T and B lymphocytes are involved and Review B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue Arne Hansen 1 , Peter E Lipsky 2 and ... homing of B cells to lymphoid follicles and in the development of organized lymphoid follicles in healthy individuals [60]. Mice deficient in the lym...

Ngày tải lên: 09/08/2014, 10:20

... or absence of coexisting anti-La/SSB [51]. Cytokine polymorphisms in Sjögren’s syndrome Cytokines serve to mediate and regulate immune and inflammatory responses, and have been implicated in the pathogenesis ... no convincing relationship has been identified (for review [52]). 359 Increased frequency of cells secreting interleukin-6 and inter- leukin-10 in peripheral blood...

Ngày tải lên: 09/08/2014, 01:21

... B lymphocytes. Rheum Dis Clin North Am 2001, 27: 335-353. 24. Weyand CM, Goronzy JJ, Takemura S, Kurtin PJ: Cell-cell inter- actions in synovitis. Interactions between T cells and B cells in rheumatoid ... regimens employing cytokine blockage and that may be well suitable for a subset of patients. Identifying the mechanisms by which B cells control disease activity will be nec...

Ngày tải lên: 09/08/2014, 01:21

... [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects. An important immunoregulatory cytokine produced by B cells is IL-10, ... stimulation for their generation [61]. These findings link ICOS and IL-21 in a definable pathway required for B-cell stimulation in secondary lymphoid organs and suggest that b...

Ngày tải lên: 09/08/2014, 14:22

... and sucrose enzyme inhibitors (amylase and sucrase) would diminish and/ or slow the breakdown of starch and sucrose in the gastrointestinal tract, diminishing glucose entrance into the blood ... effects. The formulation contained other ingredients not examined here (Gymnema sylvestre, apple extract, and green tea). We cannot state what role they played in the results. In...

Ngày tải lên: 08/08/2014, 16:23

... responsible in many cases for obesity and connected dysfunctions in insulin metabolism with many other aspects of the metabolic syndrome. While aging is associated with insulin resistance [15-17], insulin ... In turn, insulin resistance is associated with many troublesome, age-related perturbations including hypertension, dyslipidemias, diabetes, obesity and even premature a...

Ngày tải lên: 08/08/2014, 16:23

... by proinflammatory cytokines, which not only induce but also maintain synovitis and therefore play an important role in pro- gressive joint destruction [1,2]. Several cytokines are currently considered ... total numbers of syn- ovial cells and the numbers of positively stained cells in each immunohistochemical staining using a magnification of 200× or by counting positively staine...

Ngày tải lên: 09/08/2014, 07:20

... that innate immunity is also involved in early BD and interacts with adaptive immunity, as reflected by the presence of perforin, presumably secreted by CD3 + T cells. It might therefore be of interest ... Neutrophils and subsequently lymphohistiocytic cells may be observed in sterile lesions following a sterile needle prick [8]. Representing endothelial injury and functioning as...

Ngày tải lên: 09/08/2014, 14:20

... prenatally and 82% of these ended in termination of pregnancy, potentially introducing a strong bias [21]. Birth prevalence was estimated by assuming an intra- uterine survival rate following prenatal ... combat infertility are increasingly being used in couples at high risk of certain genetic inherited disorders. These couples can now be reasonably assured of a normal pregnancy...

Ngày tải lên: 02/11/2012, 11:12

... muscles and hence increased airways resistance and methacholine reactivity. Therefore, obese patients complain of more dyspnea and asthma-like symptoms than leaner patients and may be incorrectly diagnosed with ... characterized by elevation of the cytokines interleukin (IL)-4 and IL-5, which are respon- sible for the inflammatory cells infiltrating the airways. 32 Tumour necros...

Ngày tải lên: 08/08/2014, 21:20