Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis pdf
Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis pdf
... potential application in treatment of rheumatoid arthritis Dong Wang1,2, Scott C Miller3, Xin-Ming Liu1, Brian Anderson3, Xu Sherry Wang1,4 and Steven R Goldring5,61Department of Pharmaceutical ... diagnosis and treatment of RA.Although progress has been made in understanding themolecular mechanisms and identification of novel therapeutictargets for RA, challenges still remain. Most of the ... Synthesis of Dex-containing monomer and its copolymerization with HPMA mayresolve the issue. However, the synthesis and especially thepurification of the Dex-containing monomer may continue tobe...
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Báo cáo hóa học: " Facile preparation of highly-dispersed cobaltsilicon mixed oxide nanosphere and its catalytic application in cyclohexane selective oxidation" ppt
... Dalian, China. Cobalt oxide [Co3O4] (98%) denotedas C-Co3O4was purchased from Tianjin Institute of Jinke Fine Chemical, Tianjin, China.Firstly, two kinds of solution (solutions A and B) ... (0.13 g of Co(OAc)2·4H2O and 5.35 g of deionized H2O). Microemulsion was obtained withthe blending of solutions A and B. After stirring for 15min, to this microemulsion, 5.2 g of TEOS ... triphenylphosphine to therea ction mixture, cyclohexanone and cyclohexanol weredetermined by the internal standard method usingmethylbenzene as a n internalstandard.Theconcentra-tion of CHHP was determined...
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Báo cáo khoa học: Oxygen binding and its allosteric control in hemoglobin of the primitive branchiopod crustacean Triops cancriformis pdf
... simultaneousanalysis of all six binding curves, as in some casesparameters are shared between individual bindingcurves in order to reduce the number of free parametersas well as the uncertainty in the remaining ... relypredominantly on simple diffusion. Several lines of evidence [25–27], including the reduction in oxygenuptake when Hb–oxygen binding is blocked by carbonmonoxide [28] and the striking induction of ... (Fig. 7), which also visualizethe in uence of variations in the numbers of Mg2+-binding sites (m) and proton-binding sites (h) peroxygen-binding site.di-domain subunitdisulfide-bridged dimer...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... Firestein GS (1991) Cytokines in chronic in ammatory arthritis. VI. Analysis of the synovial cellsinvolved in granulocyte–macrophage colony-stimulatingfactor production and gene expression in rheumatoid arthritis ... localization, and regulation of the stress-activated protein kinases, extra-cellular signal-regulated kinase, c-JUN N-terminalkinase, and p38 mitogen-activated protein kinase, in synovial tissue and ... characteristics in RA patho-genesis [1]. FLSs play a key role in the development of sustained in ammation and angiogenesis in arthriticjoints [2–4]. Several cytokines and RA factors existing in the...
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Báo cáo khoa học: Ubiquitination of E3 ubiquitin ligase TRIM5a and its potential role pdf
... TRIM5a and its RING mutant in vitro. (A) Schematic representation of the RING-finger domain of TRIM5a.The amino acid sequence and structure of the RING-finger domain are shown. Asterisks indicate ... as a RING-finger-type E3 ubiquitin ligase both in vitro and in vivo and ubiquitinates itself in cooperation with the E2 ubiquitin-conjugatingenzyme UbcH5B. In addition to the self-ubiquitination, ... 3 and 8)ABCFig. 5. In vivo assay of self-ubiquitination and cross-ubiquitinationbetween Ro52 and TRIM5a. (A) In vivo ubiquitination by Ro52 E3ubiquitin ligase. To examine the ubiquitination...
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Báo cáo vật lý: "Synthesis and Characterization of Bismuth Tantalate Binary Materials for Potential Application in Multilayer Ceramic Capacitors (MLCC)" doc
... Pellets of single phase sample were prepared using a stainless steel die measuring 8 mm in diameter. Sufficient amount of powder was added, cold pressed uniaxially, and sintered at 1100oC in order ... Figure 9 shows the plots of real part of complex permittivity of BiTaO4 ceramics as a function of sintering temperature. The εr increases appreciably with the increase of temperature. The temperature ... function of sintering temperature. The εr increases appreciably with the increase of temperature. The temperature dependence of εr is due to a polarization effect. The number of space-charge...
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Báo cáo khoa học: "Capsular polysaccharide typing of domestic mastitis-causing Staphylococcus aureus strains and its potential exploration of bovine mastitis vaccine developmen" docx
... of capsule by the organism and theautoagglutination in the presence of low concentrations of sodium hydroxide. Although the addition of milk whey in some strains was not effective in promoting ... Staphylococcusaureus strains and its potential exploration of bovine mastitis vaccinedevelopmen. I. capsular polysaccharide typing, isolation and purification of the strains Hong-Ryul Han, Son-Il ... determined in test tubes using protein assay reagent kit(Micro BCA, Pierce, USA). CP preparation for serotyping and its detection in culture supernatantCells were suspended in PBS containing...
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Báo cáo y học: "Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production" ppt
... expression of CD147 (RA CD147), matrix metalloproteinase-1 (RA MMP-1), tissue inhibitor of metalloproteinases-1 (RA TIMP-1) and blank contrast (RA blank) in the lining and sublining layers in RA ... of CD68+ (green) and CD147+ (red) cells, and the co-expression of CD68+CD147+ cells (yellow) in the lining and sublining layers of rheumatoid arthritis syn-ovium is apparent. Arthritis Research ... MMP-2 and MMP-9 in human CD14+ monocytes from rheumatoid arthritis (RA) patients, in HFC and in a co-culture of the two. An elevated release and activation of MMP-9 and MMP-2 was seen in the...
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Globalization and its effects on the development of educational service in Vietnam
... to introduce the latest technology requiring further training. Thus, continued participation in export markets requires continuous skill upgrading through training.There is also increasing interest ... the training program for local workers in international standards. In conclusion, the increase in FDI into Vietnam not only increases the demand for quantity but also increases the demand for ... Senegal) are beginning to participate in the globalization of services production.Arora and Gambardella (2004) examine the expansion of the software industry in India, Ireland, Israel and Brazil....
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ESTROGENIC ACTIVITY LEVEL OF NAKDONG RIVER BASIN AND ITS CONTROL BY WATER TREATMENT PROCESSES
... sampling points along of Nakdong River in May, and October 2002 and in March, and September 2003. Samples were collected from 7 points in Fig. 1. Sampling points of Nakdong River basin BusanAndongDaeguWaegwanGangjungGumho ... such as prechlorination and the combination of sand filtration and ozonation in sewage treatment plants (STPs) or water treatment plants (WTPs). During water-purifying processing, estrogenic ... Concentration of estrogenic substances in mainstream and branches of Nakdong River basin Table 2. Concentration of estrogenic substances in sewage treatment plants (Number of sample = 4) Point sewage...
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