Báo cáo khoa học: "Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy" pdf
... uses of 3D-conformal techniques
in breast conserving radiotherapy.
Conclusion
The shift towards CT -guided target definition and plan-
ning as the golden standard for breast conserving radio-
therapy ... plans.
Conclusion: The shift towards CT -guided target definition and planning as the golden standard for
breast conserving radiotherapy has...
... with
the cognate tRNA. Because of the similar size of the
motif 2 loop in methanogenic-type SerRS and ThrRS
and the involvement of zinc ions in the recognition of
amino acid substrates, the M. ... experiments point to the
importance of these residues for the flexibility of the
tRNA 3¢-end binding region. The ability of the loop to
change its conformati...
... ligands in the
Mn-reconstituted enzyme and an additional water oxy-
gen, which, together with the OD2 of Asp165, the
NE2 of His79 and the NE2 of His169, formed an
equatorial plane (Fig. 3B). The metal ... Mn-reconstituted
ApeSOD, the metal ion was five-coordinate in trigonal
bipyramidal geometry (Fig. 3A). Three of the ligands,
OD2 of Asp165, NE2 of His79 and NE...
... this RNR and that of other class 1
RNRs or, instead, is a result of the interaction of the
R2F with the inactivated (oxidized) form of the R1E.
We consider the first option unlikely. Under these ... these
results confirm that product formation requires both
the R1E and R2F subunits for catalysis, as expected.
The tyrosyl radical of the R2F subunit was also
monito...
... monomer and dimer, and that Thr binding shifts
the equilibrium to dimer formation. In the absence of Thr, an outward
shift of b-strands near the Thr-binding site (site 1) and a concomitant loss
of the ... mechanism
of the elevated thermostability of TtAKb.
In this article, we describe the crystal structures of
TtAKb in two forms, Thr-bound and Thr-free, and...
... T-pIC and
M-pIC treatments induced the phosphorylation at
Ser386 and Ser396 of IRF-3, and formed the dimeriza-
tion of IRF-3 (Fig. 5A,B, lanes 1 and 2), and that
NS3-4A remarkably inhibited the ... pIFN-b-()125)-Luc and pRL-CMV (internal control reporter) and cultured for 42 h, and then
poly(I-C) (1 lg) was transfected into the cells for 6 h before the report...
... to (if not the same as) the role of
the xG in the second step of self-splicing [48–56].
This suggests that the guanosine to be excised is
likely binding to the GBS of the ribozyme for the
exon-ligation ... that there is room for improve-
ment in terms of the rate of reaction. This would be
beneficial not so much in terms of the rate of the over-
all reac...
... Ser214–Gly219 (the entrance frame), Lys224–
Tyr228 (the back of the pocket) and the disulfide bridge
Cys191–Cys220 (the front of the pocket) (Fig. 4A). The
backbones of these segments form a deep ... according to the residue in the mid-
point of the respective loop, as shown in Fig. 2. To
the east of the active site the 37- and 60-loops border
the S2¢ poc...
... Oligomerization and active site formation. Sections (6 A
˚
thick) of the protein surface that illustrate the shape and size of the
active site. The sphere represents the zinc ion. (A) The main body
of the ... cavity formed by the
residues Ile18, Ile149, Leu172, Phe179 and the aroma-
tic ring of Tyr194. The side chains of Tyr194, Asn150
and Asp108 form a h...
... the amplitudes and rate constants
of the two other phases. The above should be gov-
erned by the balance between the rate of reduction
and oxidation of the acceptor side of PSII by the avail-
able ... correspond to the
end of the J–I phase [8,28,29]. It is likely that the
emergence of a peak for I in the FI curves depends on
the relative amplitude an...