Báo cáo khoa học: "Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy" pdf

... uses of 3D-conformal techniques in breast conserving radiotherapy. Conclusion The shift towards CT -guided target definition and plan- ning as the golden standard for breast conserving radio- therapy ... plans. Conclusion: The shift towards CT -guided target definition and planning as the golden standard for breast conserving radiotherapy has...

Ngày tải lên: 09/08/2014, 09:22

... with the cognate tRNA. Because of the similar size of the motif 2 loop in methanogenic-type SerRS and ThrRS and the involvement of zinc ions in the recognition of amino acid substrates, the M. ... experiments point to the importance of these residues for the flexibility of the tRNA 3¢-end binding region. The ability of the loop to change its conformati...

Ngày tải lên: 16/03/2014, 06:20

... ligands in the Mn-reconstituted enzyme and an additional water oxy- gen, which, together with the OD2 of Asp165, the NE2 of His79 and the NE2 of His169, formed an equatorial plane (Fig. 3B). The metal ... Mn-reconstituted ApeSOD, the metal ion was five-coordinate in trigonal bipyramidal geometry (Fig. 3A). Three of the ligands, OD2 of Asp165, NE2 of His79 and NE...

Ngày tải lên: 14/02/2014, 22:20

... this RNR and that of other class 1 RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E. We consider the first option unlikely. Under these ... these results confirm that product formation requires both the R1E and R2F subunits for catalysis, as expected. The tyrosyl radical of the R2F subunit was also monito...

Ngày tải lên: 15/02/2014, 01:20

... monomer and dimer, and that Thr binding shifts the equilibrium to dimer formation. In the absence of Thr, an outward shift of b-strands near the Thr-binding site (site 1) and a concomitant loss of the ... mechanism of the elevated thermostability of TtAKb. In this article, we describe the crystal structures of TtAKb in two forms, Thr-bound and Thr-free, and...

Ngày tải lên: 18/02/2014, 08:20

... T-pIC and M-pIC treatments induced the phosphorylation at Ser386 and Ser396 of IRF-3, and formed the dimeriza- tion of IRF-3 (Fig. 5A,B, lanes 1 and 2), and that NS3-4A remarkably inhibited the ... pIFN-b-()125)-Luc and pRL-CMV (internal control reporter) and cultured for 42 h, and then poly(I-C) (1 lg) was transfected into the cells for 6 h before the report...

Ngày tải lên: 18/02/2014, 16:20

... to (if not the same as) the role of the xG in the second step of self-splicing [48–56]. This suggests that the guanosine to be excised is likely binding to the GBS of the ribozyme for the exon-ligation ... that there is room for improve- ment in terms of the rate of reaction. This would be beneficial not so much in terms of the rate of the over- all reac...

Ngày tải lên: 18/02/2014, 18:20

... Ser214–Gly219 (the entrance frame), Lys224– Tyr228 (the back of the pocket) and the disulfide bridge Cys191–Cys220 (the front of the pocket) (Fig. 4A). The backbones of these segments form a deep ... according to the residue in the mid- point of the respective loop, as shown in Fig. 2. To the east of the active site the 37- and 60-loops border the S2¢ poc...

Ngày tải lên: 19/02/2014, 00:20

... Oligomerization and active site formation. Sections (6 A ˚ thick) of the protein surface that illustrate the shape and size of the active site. The sphere represents the zinc ion. (A) The main body of the ... cavity formed by the residues Ile18, Ile149, Leu172, Phe179 and the aroma- tic ring of Tyr194. The side chains of Tyr194, Asn150 and Asp108 form a h...

Ngày tải lên: 19/02/2014, 00:20

... the amplitudes and rate constants of the two other phases. The above should be gov- erned by the balance between the rate of reduction and oxidation of the acceptor side of PSII by the avail- able ... correspond to the end of the J–I phase [8,28,29]. It is likely that the emergence of a peak for I in the FI curves depends on the relative amplitude an...

Ngày tải lên: 19/02/2014, 05:20