Báo cáo khoa học: "Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy" ppt

... RESEARC H Open Access Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy Janine M Davies 1,2* , Dimitri Trembath 3 , ... during follow-up, a finding that is limited given the small number of patients. AKT activation status, but not ERK activation status, correlates...

Ngày tải lên: 09/08/2014, 09:21

... to investigate structure and function in several integral membrane proteins [15–20]. This approach has proved to be very successful in providing qualitative structural information and in guiding ... protons are involved in hydrogen bonds or are largely shielded from solvent access [44]. These experiments have also been used recently to determine the residues which are involv...

Ngày tải lên: 16/03/2014, 16:20

... limited, but the interest in their structure is increasing, especially in the structural analysis of O-specific polysaccharides (OPSs) [1]. The main purposes of these investigations are to establish ... fragment ions corresponding to losses of reducing end or nonre- ducing end Rha in the PSD spectra shown in Fig. 8A and B, probably reflects structural features of the studied ions...

Ngày tải lên: 31/03/2014, 09:20

... Pinus pinaster Ait. en Galicia. Premio ENCE de Investigación Forestal, 1992 (unpublished). [17] Miina J., Optimizing thinning and rotation in a stand of Pinus sylvestris on a drained peatland ... concepts were introduced in Northwestern Spain as a result of increasing harvesting costs and stagnating pulpwood prices. Nowadays, maritime pine stands in Galicia are grown for a produc...

Ngày tải lên: 08/08/2014, 14:22

... centre. The intensive care unit (ICU), emergency room, inpatients wards, psychiatric and surgery clinics were not part of the sampling frame. All persons associated with health care including doctors, ... that the observations are a constant fac- tor in the studied population or a finding at only one point in time. We also did not include patients who could not converse in...

Ngày tải lên: 08/08/2014, 23:20

... the interaction between amylin and insulin rather than the self-assembly of insulin. Considering the observation that insulin can copolymerize with amylin after long-term incubation, insulin may ... dimers and hexamers in solution [18,19]. As shown in Fig. 6, it seems that the peak at 30 min contained insulin hexamers, and the peak at 40 min contained insulin monomers and dimers...

Ngày tải lên: 23/03/2014, 04:21

... that Akt1 inhibits JNK activation, where Akt1 interaction with JNK interacting protein 1 (JIP1) inhibited JIP1 binding to specific JNK pathway kinases, such as mixed-lineage kinase (MLK) and JNK. ... pathway but not ERK and p38 MAP kinase pathways are important for AP-1 activation induced by TRAF6 and c-Src. Further- more, we presented that PI3-kinase inhibitor or Akt DN inhi...

Ngày tải lên: 31/03/2014, 07:20

... -1 °C and sown during the following August in individual pots containing a 50/50 v/v mixture of peat/sandy loam. They were transplanted int 5-I, 25-cm deep pots with the ... potential, and mineral status in xylem sap and stems (see Colin-Belgrand et al, 1991). A and g were measured weekly in the same shoot bearing 3-4 leaves of 4 see...

Ngày tải lên: 08/08/2014, 23:21

... protein kinase; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine ... cytokinins in tobacco plants grown on media supplemented with isopentenyl ade nine, zeatin and dihydrozeatin ribo side is presented. Differences in phenotypes are discussed ODE sim, fit, s...

Ngày tải lên: 14/02/2014, 14:20

... compete with histone H1 in condensed chromatin fibres to create localized disruptions within repressed chromatin domains. FoxA1 and FoxO1 interact with histones H3 and H4 and can thereby disrupt inter-nucleosomal ... proteins con- taining methyl binding domains (MBDs) which assem- ble complexes containing repressive HMT and DNMT proteins that act in a concerted fashion to maint...

Ngày tải lên: 14/02/2014, 18:20