Báo cáo khoa học: "Clostridium difficile-associated diarrhea in radiooncology: an underestimated problem for the feasibility of the radiooncological treatment" doc

... feasibility of the radiooncological therapy in terms of interruption orabandonment of the radiotherapy, change of therapyconcept and the effect on the feasibility of chemother-apy were evaluated.Induced ... at risk of developing CDAD. The aim of this analysis is to determine the incidence of CDAD in radiooncological patients and to find out whatrelevance CDAD has for the feasibility of the radiooncological ... describes an incidence of 0,1% for Europe and an incidence of 0,1%to 2% for the USA [3]. Heinlen et al. could found an incidence of 0,6% for the USA in the year 2003 [28].Especially the patients...

Báo cáo khoa hoc:" Papillary carcinoma arising in a thyroglossal duct cyst with associated microcarcinoma of the thyroid and without cervical lymph node metastasis: a case report" pot

... difficulty lies in Papillary cancer in the left lobe of the thyroidFigure 2Papillary cancer in the left lobe of the thyroid. (H&E).Papillary carcinoma evolving from a TGDC, confined to the thyroglossal ... aysmpto-matic, soft, firm, or hard masses in the midline of the anterior neck, and are nontender and generally movable.Malignant thyroglossal duct cysts present in the samemanner. Carcinoma should ... diameter of 2cm (Figure 1). The patient was referred to the surgerydepartment for further investigation. Thyroid scintigra-phy, ultrasound and cervical CT scans were performed. The thyroid scintigraphy...

Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"

... could influence the statements of the interviewed e.g., the use of leading ques-tions. In the phase of analysis it is important to determine whenno additional information can be extracted from the ... consequences of bias and variation in veterinary recordsVeterinary medical records can be applied in the dairy sec-tor in many ways and for many reasons. In the followingwe will discuss the consequences ... sodifferent.ConclusionVariation and bias in data based on clinical examinationscan be linked to veterinarians' individual perception of the purpose of, and their motivations for, data collection.Some veterinarians...

Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for ampliﬁcation of mitochondrial apoptotic cell death in human cervical cancer cells pptx

... seem to play an important role in determining the radiationresponse of tumor cells. However, the basis of the linkbetween the signaling pathway and the apoptotic cell-death machinery in response ... recommendations.Quantiﬁcation of cell deathApoptosis was investigated by Annexin V labeling using aSigma-Aldrich kit according to the manufacturer’s instruc-tions. Annexin V–ﬂuorescein isothiocyanate ... anti-cytochrome c and anti-a-tubulin serum. The total cell extract was subjected to western blot analysis usinganti-phospho-JNK, anti-JNK, anti-caspase-3 and anti-b-actin serum. a-tubulin and b-actin were...

Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt

... those events. In addition, these data point tofurther differences in the modes of transcriptionalregulation of the individual TPa and TPb isoforms in humans and imply potentially important physiologicdifferences ... [48] and thereby impliesthat PPARc isoforms may have a role in mediating the 15d-PGJ2–inhibition of Prm3 activity. The involvement of both PPARc and the retinoic acid Xreceptor (RXR) in the ... in the absence of exogenous RNA acted as a control (lane 1). The arrow to the right of (A) indicates the position of the hPPARc2 (lane 2) andmRXRa (lane 3) in vitro translated products. (B and...

Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt

... andprovides an insight into the enzyme’s mechanism of action in the C. albicans cell wall. Finally, the unex-pected discovery of an isolated binding site remote from the active site poses the intriguing ... structure of this GH5enzyme in the presence of two different mechanism-based inhibitors, thereby revealing the close network of interactions that hold the terminal glucose of the b-glucan substrate ... enzyme. The role of the Phe-Phe entranceway The fortuitous discovery of an unreacted molecule of the mechanism-based inactivator 2¢,4¢-dinitrophenyl-2-deoxy-2-ﬂuoro-b-d-glucopyranoside bound in the crystal...

Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx

... the recombinant proteindeveloped for measuring [Ca2+] within the mitochond-rial matrix and was instrumental in gaining new insightinto mitochondrial Ca2+handling, i.e. the topic of thisreview ... organelle-targetedaequorin chimeras [52]. An interesting scenarioemerged, with distinct roles for the various isoforms.Overexpression of PKCe did not modify the amplitudeand the kinetics of either the cytosolic and ... fusion and include EF-hand Ca2+bind-ing sites in their sequence [63]. In our work, we took advantage of the molecularknowledge of the fusion ⁄ ﬁssion machinery for activelymodifying the three-dimensional...

Báo cáo khoa học: "Hedge classiﬁcation in biomedical texts with a weakly supervised selection of keywords" doc

... further 30% of the candidates andkept 253 uni-, bi-, and trigrams altogether.This efﬁcient way of reranking and selecting po-tentially relevant features (we managed to discard89.5% of all the ... (evaluated in the Resultssection) which is capable of underranking irrelevantkeywords in the majority of cases.2.3 Feature (or keyword) selectionTo handle the inherent noise in the training datasetthat ... classwhere P = R. If an exact P = R cannot be realised due to the equal ranking of many instances, we use the point closestto P = R and set BEP (spec) = (P + R)/2. BEP is an 284BMC Bioinformatics website...

báo cáo khoa học: "Factors influencing success in quality-improvement collaboratives: development and psychometric testing of an instrument" pdf

... responsibility for the integrity of the data and the accuracy of the data analysis. All authors readand approved the final manuscript.Competing interests The authors declare that they have no competing interests.Received: ... items of expert-opinion-baseddeterminants of success [15]. Two reviewers (LS andMH) analysed the list of determinants to identify pro-blems with wording or meaning and redundancy or rele-vancy ... represents an index of an instrument’s reliability [20,21].As the QIC instrument was an assembly of items in four subscales designed to quantify agreement with the determinants of succe ss in a QIC,...

báo cáo khoa học: "Implementing health research through academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC)" pot

... anduse of knowledge as they occur over the lifespan of the evaluation and beyond the initial funding period of the CLAHRCs (2008 to 2013). The outputs of the study willbe both theoretical and ... emerging findings.This evaluation was funded to provide inform ation for learning, not for judgement. The purpose of the evalua-tion is formative, focusing on processes and a range of potential and ... implementa-tion and internal evaluation plans with each CLAHRC.Once gathered, we will analyse and synthesise the datausing concept mining, developing analytical themes andframework development. The framework...

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