Báo cáo khoa học: "Laparoscopic insertion of pelvic tissue expander to prevent radiation enteritis prior to radiotherapy for prostate cancer" pdf

... 6:47http://www.ro-journal.com/content/6/1/47Page 3 of 6CASE REP O R T Open AccessLaparoscopic insertion of pelvic tissue expander to prevent radiation enteritis prior to radiotherapy for prostate cancerGary D McKay1, ... those with a low pelvic peritoneal reflection allowingloops of small bowel to enter the radiation field. Laparoscopic insertion and subsequent removal of a pelvic tissue expander before and after ... been a candidate for EBRT due to loops of bowel low in the pelvis. With laparoscopic insertion andsubsequent removal of a tissue expander, he was able to have radiotherapy to the prostate without...

Báo cáo khoa học: "Early administration of IL-6RA does not prevent radiation-induced lung injury in mice" pot

... the negative findings of ourstudy, further intensive studies are needed into strategies for inhibition of cytokine signaling as a way to ameliorat-ing lung toxicity from radiotherapy. Competing ... paradigm of IL-6: from basic science to medicine. Arthritis Res 2002, 4(Suppl 3):233-242.9. Nishimoto N, Kishimoto T: Inhibition of IL-6 for the treatment of inflammatory diseases. Curr Opin Pharmacol ... interleukin-6 receptor antibody. Immunol Lett 2002, 84:231-240.16. Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T: Treatment of rheumatoid arthritis...

Báo cáo khoa học: " The influence of smoking and other risk factors on the outcome after radiochemotherapy for anal cancer" ppt

... planned total dose of radiotherapy. In thiscase radiochemotherapy was stopped after first cycle of chemotherapy at a dose of 43 Gy because of toxicity andold age of the patient. The intensity of ... 0.69).Colostomy free survival (CFS)63 patients were colostomy free at the beginning of ther-apy. The actuarial colostomy free survival at 5 years was84%. All colostomies were performed because of ... risk factor for the development of analcancer is well known, no data about the influence of smoking during combined radiotherapy on the outcomeafter therapy exist as of now. The exact role of smoking...

Báo cáo khoa học: The propagation of hamster-adapted scrapie PrPSc can be enhanced by reduced pyridine nucleotide in vitro pdf

... converted into aPK-resistant isoform in the presence of NADPH. Aliquots of ScBH of SHa-263K were serially diluted into solutions of rSHaPrP or rHu-PrP, with ﬁnal ScBH dilutions of 10)3,10)4,10)5and ... the inﬂuence of NADPH on the ability of PrPSc to propagate in PMCA, a serial PMCA protocol con-sisting of seven rounds was conduced (Fig. 1A). Prior to mixing with a 10)2dilution of ScBH prepared ... vitro.rSHaPrP could be converted into the PK-resistantisoform by addition of NADPH in PMCA To investigate whether NADPH helps native PrPSc to induce the conformation change in recombinant PrP,puriﬁed...

Báo cáo khoa học: Biochemical characterization of USP7 reveals post-translational modiﬁcation sites and structural requirements for substrate processing and subcellular localization pptx

... theinhibitor of jB kinase, a regulatory role can be pre-sumed for USP7 phorsphorylation. The identiﬁcation of K869 as the ubiquitination site of USP7 representsadditional evidence for the interaction ... proteins. They areresponsible for the disassembly of ubiquitin chains, and for the cleavage of mono- and oligomers of this mole-cule, either in precursor form or attached to smallKeywordsbiochemical ... [11]point to further roles for this DUB in the maintenance of cell homeostasis. Additional evidence for the crucialrole of USP7 is provided by the fact that targeting thisenzyme belongs to the...

Báo cáo khoa học: The mystery of nonclassical protein secretion A current view on cargo proteins and potential export routes pdf

... viral promotor, about 40% of total rhodanese was found to be secreted into the culturemedium [119]. Export was shown to occur in the absence of appreciable amounts of cell death and to depend ... activators of tumor-induced angiogenesis [45]. The majority of themembers of the FGF family are exported by ER/Golgi-dependent secretory transport. However, FGF-1 and the18 kDa isoform of FGF-2 ... inhibitor of enzymatic activity as it isnot cleaved off in the matrix), it was concluded that thepopulation present in the cytoplasm remains unfoldedbefore import into mitochondria. Therefore,...

Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf

... modi-ﬁcation of LDL is capable of eliciting cytotoxicity,differentiation, and inﬂammation in neuronal cells [10–12,38]. Suppression of oxidative modiﬁcation of LDLby antioxidants may be effective in preventing ... 1275is cytotoxic to neurones and application of antioxi-dants may attenuate neurone death. Thus, inhibition of LDL peroxidation by antioxidants becomes anattractive therapeutic strategy to prevent ... 0.25 mHCl) was added, together with 0.02% w ⁄ v BHT. Thisamount of BHT completely prevents the formation of any nonspeciﬁc TBARS, as well as preventing decomposi-tion of AAPH during the subsequent...

Báo cáo khoa học: Functional transitions of F0F1-ATPase mediated by the inhibitory peptide IF1 in yeast coupled submitochondrial particles pdf

... burst of NTP hydrolysis. We propose thatthe protonmotive force induces the conversion of IF1-inhibited F0F1-ATPase into a new form having a loweraﬃnity for IF1. This form remains inactive for ... motor, with an asymmetricalrotor composed, in mitochondria, of c, d and e subunits,anchored to a membranous decameric ring of c subunitsthought to compose a proton-driven turbine [7].Mitochondrial ... IF1-freelatent form.This outline of mechanism can explain the synergeticeffect of IF1 and D~lHþon the formation of the latentform in the presence of MgATP. These three effectorsmust be...

Báo cáo khoa học: Identiﬁcation of a 250 kDa putative microtubuleassociated protein as bovine ferritin Evidence for a ferritin–microtubule interaction pdf

... inABFig. 3. Iron storage and uptake activity of the 250 kDa protein. (A) Detection of iron in the 250 kDa protein: potassium ferrocyanide wasadded to a ﬁnal concentration of 10 mM to all of the fractions ... degradationand the prevention of unwanted iron release into thecell. Unfortunately, the nature of this aggregation isunclear at present. It might be an intrinsic feature of ferritin molecules to aggregate ... more of these proteins. Therefore, weobserved the effect of total MAP fractions on the ferr-itin–microtubule interaction. The total MAP fractionwas prepared so that it contained most of the...

Báo cáo khoa học: Structural basis of charge transfer complex formation by riboﬂavin bound to 6,7-dimethyl-8-ribityllumazine synthase docx

... the Cc-atom of H94 and the N 7-atom of CEOL: wild-type enzyme:6.5 A˚;W27Ymutant:6.1A˚).The smallest distance between t he Cc-atom of H94 andthe inhibitor plane (N5-atom of riboﬂavin) ... the ﬂavin c ofactor and appears to disfavourthe formation of the electron rich hydrochinone form.Furthermore, p-stacking interactions play a role in proteinbinding of ﬂavins. For example, ... discoveredﬂavoprotein dodecin, a pair of tryptophans facilitates theformation of a unique tetrade comprising of a pair of riboﬂavins with an antiparallel staggering of their isoallox-azine moieties,...

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