Báo cáo khoa học: "Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo" docx

... Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo. Radiation Oncology 2010 5:70. Submit your next manuscript to BioMed Central and ... Access Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs...

Ngày tải lên: 09/08/2014, 09:20

... Substitution of glutamate-3 valine-19 leucine-23 and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltrans- ferase I abolishes malonyl CoA inhibition and binding. Arch ... H128P, PigE17DCPT1B and HumanD17ECPT1B, and from 0 to 500 lm for D 18PigCPT1B and D28PigCPT1B). The assay was performed at 1 mm carnitine as standard. To analyze Pi...

Ngày tải lên: 16/03/2014, 04:20

... High-throughput screening of enzyme inhibitors: Automatic determination of tight-binding inhibition constants. Anal Biochem 281, 62–67. 20 Bates DM, Watts DG (1988) Nonlinear regression analy- sis and its ... competitive kinetic pattern. Reliably determining the kinetic mechanism of inhibition is important, Keywords aminoglycosides; Bacillus anthracis; inhibition; lethal factor p...

Ngày tải lên: 19/02/2014, 06:20

... Carboxylate-containing residues and carbonyl oxy- gens involved in cation binding are shown as sticks. The figure was generated with PYMOL [32]. Positioning of the Ca 2+ , ATP and PDZ6 domain binding sites in ... cells, high levels of d-serine can be detected in the supernatant. Conse- quently, we transfected brain SR in COS7 cells in the presence and absence of transf...

Ngày tải lên: 30/03/2014, 03:20

... oncogene in ovarian and breast carcinomas. Int J Cancer 1995, 64:280-285. 8. Staal SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a ... radiotherapy. In this study, we investigated the effect of the combined treatment of perifosine and radiation (CTPR) on prostate cancer cells in vitro and on prostat...

Ngày tải lên: 09/08/2014, 09:20

... step 2, binding reaction; step 3, array scanning; and step 4, data processing and analysis. Differential glycan profiling between cancer and normal cells enables identification of aberrant glycosylation ... involved in wound heal- ing and in ammation. In association with cancer growth, the stromal cells grow and expand to release many glycoproteins into serum. Thus, se...

Ngày tải lên: 16/02/2014, 08:20

... cultured in minimal essential medium with Ear- le’s salt and l-glutamine (Invitrogen, Karlsruhe, Germany) containing 10% fetal bovine serum (Invitrogen) and anti- biotics. Cells were incubated ... forma- tion in human RCC and colon cancer cells, and in addition induced upregulation of TIMP-1. Upregula- tion of TIMP-1 was reversed by catalase, indicating that this effe...

Ngày tải lên: 19/02/2014, 05:20

... Upon heating, the shape of the amide I band of HPr changed dramatically at pH 2.5 and 7.5, as shown by: (a) a substantial loss in the integrated intensity of bands arising from ahelix and (b) ... contains 93 amino acid residues; it lacks cysteine and tyrosine, but it has a large number of alanine, valine and leucine residues. Furthermore, the protein only contains one trypt...

Ngày tải lên: 31/03/2014, 01:20

... Giannitelli C, Ferrandina G, Masciullo V, Bellacosa A, Benedetti-Panici P, Mancuso S: Analysis of cyclin E and Cdk2 in ovarian cancer: gene amplification and RNA overexpression. Int J Cancer 1998, 75:34-39. 36. ... histologically active and can function as regu- lators of invasion and metastasis since they can form angiogenic tumors with prominent perineural invasion and...

Ngày tải lên: 09/08/2014, 03:24

... development and occurs in response to physical exercise [1], resulting in an increase in fiber size accompanied by the increased expression of insulin-like growth factor 1 (IGF-1) [2,3]. Since IGF-1 overexpression ... (LY). The cells were visualized by Giemsa stain- ing. (B) RT-PCR analysis of endogenous IGF-1 transcript in C2BP5 cells grown in DM for 48 h. (C) West...

Ngày tải lên: 19/02/2014, 06:20