Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-

Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt

... significantly increased during CIA development. Figure 3 Induction of Synoviolin (SYN) expression by proinflammatory cytokinesInduction of Synoviolin (SYN) expression by proinflammatory cytokines. ... CIA. Conclusion This study demonstrated that the proinflammatory cytokines IL-1β and TNF-α induce synovial fibroblast growth by upregulating the expression of...

Ngày tải lên : 09/08/2014, 08:23

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Báo cáo Y học: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells pptx

... protein in the absence or presence of tyrosine-phosphorylated peptides or phosphotyrosine (P -Y) . The peptides correspond to tyrosines 113, 128 and 145 in SLP-76 and tyrosines 174 and 692 in Vav. ... deletion of the nucleotides 880–1603 in the Shb cDNA (containing the four tyrosine phosphory- lation sites and the PTB domain), using the restriction enzymes Fs...

Ngày tải lên : 24/03/2014, 04:21

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Báo cáo y học: "Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model" doc

... daily thereaf- ter for signs of distress. Kaolin and food pellets were weighed to the nearest 0.1 g and placed in containers within the cage each morning. The kaolin and food remaining from the ... and pain treatment in AIDS patients: a longitudinal study. J Pain Symptom Manage 2000, 19:339-347. 27. Yuan CS: Methylnaltrexone mechanisms of action and effects on opioid...

Ngày tải lên : 10/08/2014, 05:21

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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

... Frequency of the MTHFR genotypes and the result of the Chi square testing in the different studied groups. Showing the frequency and the results of the cross tabulation of the T allele and the different ... of cytosine (C) by thymine (T) at nucleotide 677 of the MTHFR gene that converts an alanine to a valine residue was responsible for the therm...

Ngày tải lên : 03/11/2012, 09:49

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Tài liệu Báo cáo Y học: Puriﬁcation, characterization, cloning, and expression of the chicken liver ecto-ATP-diphosphohydrolase pot

... right side of the figure. The transmembranous domains of the protein at the N- and C-terminus are shaded. The five apyrase conserved regions (ACRs) are underlined and in bold. The 10 cysteine residues ... 0.2 and 0.64 depending on the pH and the presence of NP-40; (d) Fig. 3. Inhibition of ATP and ADP hydrolysis activities of purified chicken liver ecto-ATPD...

Ngày tải lên : 22/02/2014, 04:20

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Tài liệu Báo cáo Y học: Puriﬁcation, characterization, immunolocalization and structural analysis of the abundant cytoplasmic b-amylase from Calystegia sepium (hedge bindweed) rhizomes ppt

... found in soybean b-amylase (Cys82, Cys97, Cys208 and Cys343). On the analogy of the soybean b-amylase, the active site of the C. sepium b-amylase most probably consists of a cleft located between the ... the activity of the enzyme was measured by the dinitrosalicylic acid method. Inhibition of the enzyme activity by glucose, maltose and cyclohexaamylose For...

Ngày tải lên : 22/02/2014, 07:20

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Báo cáo Y học: Amino acids 3–13 and amino acids in and ﬂanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

... 5787 Amino acids 3–13 and amino acids in and ﬂanking the 23 FxxLF 27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor Karine Steketee 1, *, ... assay, and the absence of a second transactivation domain linked to AR NTD in the mammalian assay. The latter assay completely depends on the intrinsic transac- ti...

Ngày tải lên : 17/03/2014, 10:20

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Báo cáo Y học: GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines doc

... the a chains (CD25) in the vicinity of signaling IL-2R b and c c chains, forming a common signaling platform in the membrane, before cytokine stimulation. This ÔfocusingÕ effect may enhance the ... conjugated antiphosphotyrosine antibody (ICN) and developed by ECL assay. (The X-ray ﬁlms were digitized and normalized for the protein content of the membrane determined...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt

... or, in certain cases, by the lysosomes/vacuole and rapidly degraded. Ubiquitination of target proteins involves a cascade of reactions catalysed by the E1, E2 and E3 enzymes. Ubiquitin (Ub) is ... between the human and yeast proteins. Therefore, Ub is not an optimal antigen and anti-Ub Ig rarely possess good afﬁnity. Taking this into account and that anti-Ruk Ig ar...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo Y học: A new high afﬁnity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx

... phosphotyrosine binding pocket. The binding of the peptide F429pY431 thus involves a shift of two residues when compared to the binding mode of pY429pY431 with pY431 binding into the classical pY-binding ... specifically interact with the tyrosine motifs pY401 and pY429pY431. pY429pY431 was more potently recruiting SOCS-3 than pY401, reflecting the high affinity binding deter...

Ngày tải lên : 24/03/2014, 00:21

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