Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis" doc

... potent inhibitor for the synthesis of proin- flammatory cytokines in monocytes /macrophages and T cells [11], is substantially expressed by lining macrophages and infiltrating T cells in the inflamed ... 4 Induction of mRNA expression of type 1 and type 2 tumour necrosis factor receptor (TNFR1/2) in monocytes by interleukin-10 (IL-10)Induction of mRNA expres...

Ngày tải lên: 09/08/2014, 08:22

... with actinomy- cin D and followed the kinetics of TCTP mRNA decay (Fig. 6). Interestingly, inhibition of transcription by actinomycin D treatment did not accelerate mRNA decay as expected; instead, ... in uence of the UTRs by a factor of 3 in reporter gene assays. Proto- types of metal-inducible genes, which play an important role in metal ion homeostasis and which ar...

Ngày tải lên: 16/03/2014, 05:20

... Wuhan City, Hubei province, China. Participa- tion was voluntary. Detection of mannose-binding lectin gene polymorphisms Polymorphisms in codons 54 and 57 of the MBL gene were analyzed by PCR-restriction ... Turner MW: Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today 1996, 17:532-540. 2. Turner MW: The role of mannose-binding lectin i...

Ngày tải lên: 09/08/2014, 08:22

... immune cells in response to TNFα; once released, HMGB1 in turn induces production of several proinflammatory cytokines – including IL-6 and TNFα – by macrophages. Whether HMGB1- induced arthritis ... article Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling Rille Pullerits 1 , Ing-Marie Jonsson 1...

Ngày tải lên: 09/08/2014, 10:23

... issociated single cells after u sually 5 days and reach sizes of  5 mm; they contain proliferating cells and their interior is surrounded by an almost complete single-cellular layer of epithelial-like ... to strongly inhibit protein synthesis i n s ponge cells [22], it is concluded that the (2–5)A synthetase system is involved in defense against microorganisms, very likely by i...

Ngày tải lên: 21/02/2014, 15:20

... supported by the existence (at least in Ets-1 and Ets-2) of an auto- inhibitory domain w hich, in t he absence of a ccessory factors, prevents Ets-1 binding to DNA [ 10,17]. W hen this d omain i s removed, ... s removed, Ets-1 binds DNA with higher af®nity even in the absence of a ccessory factors. The auto-inhibitory domain is located within exon VII and a n alternative ly...

Ngày tải lên: 17/03/2014, 17:20

... is calculated by dividing the counts/min in the presence of CII by the counts/min in the presence of ovalbumin. Analyses of cytokine production by ELISA Mononuclear cells were isolated from the Peyer’s ... are involved in the induction of peripheral tolerance in an orally tolerized mouse model of arthritis. Our findings indicate that the serum levels of pro- inflamma...

Ngày tải lên: 09/08/2014, 01:23

... involved in designing the study and in writing the manuscript under the guidance of RH. DS and TK produced the recombinant proteins (hG6PI, mG6Pi and hCK) and were involved in designing the study and ... useful in investigating ankylosing spondylitis because it generates inflammation of vertebral joints followed by ankylosis after a single round of immunization. Care...

Ngày tải lên: 09/08/2014, 07:20

... was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. aureus ... expression of a 92-kD gelatinase (type V collagenase) by rheumatoid syno- vial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Cli...

Ngày tải lên: 09/08/2014, 08:23

... Westburn Lane, University of St Andrews, Fife, KY16 9TS, UK 2 Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Science, 46 Cleveland St, University College London, London, ... with phorbyl-12-myristate-13-acetate (PMA) and ionomycin. Significantly, the formation of HLA-B27 homodimers in transfected KG-1 cells is induced by maturation, with a tran...

Ngày tải lên: 09/08/2014, 13:21