Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations" potx

... tight, binding of PLP to the apoenzyme in vitro and for the fact that preparations of the mutant enzymes are always largely as apoenzyme. Similarly, in exibility of the protein would also explain ... Lys276 is, either directly or indirectly, involved in correctly positioning the Ca-COO – bond orthogonal to the plane of the delocalized cofactor imine system. Moreover, the rele...

Ngày tải lên: 31/03/2014, 08:20

... PAR-2 in OA compared with normal chondrocytes may be related, in addition to the stimulatory effect of the cytokines, to an increased level of serine pro- teases in OA cartilage. Indeed, according ... study suggest that PAR-2 acti- vation would play a key role in the catabolic and inflammatory pathways that take place during OA by inducing the synthesis of major catabolic an...

Ngày tải lên: 09/08/2014, 10:22

... the endothelial cells of Figure 1 Examples of immunohistochemical staining for CDMPs in human intervertebral discExamples of immunohistochemical staining for CDMPs in human intervertebral disc. ... block of tissue, incorporating AF and NP in continuity was fixed in 10% neutral buffered formalin, decalcified in EDTA and processed into paraffin wax. Sections were taken for...

Ngày tải lên: 09/08/2014, 14:22

... activating receptor KIR3DS1 and the inhibitory 3DL1 are located in the intracytoplasmic tail. The inhibitory receptor has a long tail containing immunoreceptor tyrosine inhibitory motifs, whereas ... HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I rece...

Ngày tải lên: 09/08/2014, 08:22

... HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I receptors has ... ankylosing spondylitis; HC = heavy chain; HLA = human leukocyte antigen; HWE = Hardy-Weinberg equilibrium; ILT = immunoglobulin-like lymphocyte T receptors; KIR = killer cell immun...

Ngày tải lên: 09/08/2014, 08:22

... filter. RESULTS Binding of Yb 3+ to apo-hTf The thermodynamics of binding of Yb 3+ to apoTf. Binding of Yb 3+ to apo-Tf was investigated by addition of aliquots of Yb 3+ to a solution of apo-TF in 100 ... study of uptake of Yb 3+ by human Tf (hTf) by UV-vis and NMR spectroscopy, and inductively coupled plasma atomic emission spectro- metry (ICP-AES). The binding...

Ngày tải lên: 08/03/2014, 09:20

... methylcitrate into 2-methylisocitrate. PrpD is involved in the dehydration of (2S,3S)-methylcitrate to 2-methyl-cis- aconitate. The elimination of water from (2S,3S)-methyl- citrate to 2-methyl-cis-aconitate ... cycle enzyme, whereas AcnA is an anaerobic stationary-phase enzyme which is specifically induced by iron and redox stress [29]. Interestingly, two enzymes are involved in t...

Ngày tải lên: 17/03/2014, 10:20

... in the auditory cortex. One should keep in mind that, understanding of the exact way of processing the auditory information at the level of the au- ditory cortex, is still incomplete. It is in ... contribution of auditory evoked potentials in the diagnosis of sensorineural hearing loss in infancy and early childhood PhD Thesis. Aristotelian University of Thessaloniki, Ot...

Ngày tải lên: 08/08/2014, 20:23

... discrepancy of cytokine synthesis in patients with RA versus HDs upon the influence of catecho- Figure 3 Influence of catecholamines on cytokine ratios and intracellular interferon (IFN)-γ expression in ... examined by taking history, physical examina- tion, and laboratory findings (erythrocyte sedimentation rate, C-reactive protein [CRP], rheumatoid factor, anti-nuclear anti- bodie...

Ngày tải lên: 09/08/2014, 08:22

... previously described, staining of human synovial tissue with haematoxylin and eosin showed an increase in the number of cell layers of the synovial lining of RA patients (Figure 1). E- cadherin staining ... Administra- tion of BMP-7 to healthy FLSs in vitro had no effect on α-sma Figure 1 Haematoxylin and eosin staining on healthy and arthritic synovial tissueHaematoxylin an...

Ngày tải lên: 09/08/2014, 08:23