Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations" potx
Báo cáo Y học: Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli pptx
... tight, binding of PLP to the apoenzyme in vitro and for the fact thatpreparations of the mutant enzymes are always largely asapoenzyme. Similarly, in exibility of the protein would alsoexplain ... Lys276 is, either directly orindirectly, involved in correctly positioning the Ca-COO–bond orthogonal to the plane of the delocalized cofactorimine system. Moreover, the release of cofactor ... nm-absorbing hydrated form of PLP in themutant enzymes. Conversely, the less hydrated environ-ment of the high-pH conformation favors the 340 nm-absorbing enolimine tautomer of the wild-type cofactorand...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... PAR-2 in OA compared with normalchondrocytes may be related, in addition to the stimulatoryeffect of the cytokines, to an increased level of serine pro-teases in OA cartilage. Indeed, according ... study suggest that PAR-2 acti-vation would play a key role in the catabolic and inflammatorypathways that take place during OA by inducing the synthesis of major catabolic and inflammatory mediators ... MMP-13 bylicofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygen-ase, in human osteoarthritic chondrocytes is mediated by theinhibition of the p38 MAP kinase signalling pathway. AnnRheum...
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Báo cáo y học: "Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells" potx
... the endothelial cells of Figure 1Examples of immunohistochemical staining for CDMPs in human intervertebral discExamples of immunohistochemical staining for CDMPs in human intervertebral disc. ... block of tissue, incorporating AF and NP in continuity wasfixed in 10% neutral buffered formalin, decalcified in EDTA andprocessed into paraffin wax. Sections were taken for H&Estaining to ... preliminary in vitrostudy into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2006,87:17-28.39. Le Maitre CL, Hoyland JA, Freemont AJ: Interleukin-1...
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Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations." pps
... activating receptor KIR3DS1 and theinhibitory 3DL1 are located in the intracytoplasmic tail. Theinhibitory receptor has a long tail containing immunoreceptortyrosine inhibitory motifs, whereas ... HLA-B27 by KIR orILT could influence their immunomodulatory function and mayimply a role in inflammatory disease.Binding of the KIR3DL1 receptor to the Bw4 family of MHCclass I receptors has ... ankylosing spondylitis; HC = heavy chain; HLA = human leukocyte antigen; HWE = Hardy-Weinberg equilibrium; ILT = immunoglobulin-like lymphocyte T receptors; KIR = killer cell immunoglobulin-like...
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Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations" potx
... HLA-B27 by KIR orILT could influence their immunomodulatory function and mayimply a role in inflammatory disease.Binding of the KIR3DL1 receptor to the Bw4 family of MHCclass I receptors has ... ankylosing spondylitis; HC = heavy chain; HLA = human leukocyte antigen; HWE = Hardy-Weinberg equilibrium; ILT = immunoglobulin-like lymphocyte T receptors; KIR = killer cell immunoglobulin-like ... http://arthritis-research.com/content/8/4/R101Page 1 of 5(page number not for citation purposes)Vol 8 No 4Research articleContribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populationsCarlos...
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Báo cáo Y học: Complexation of ytterbium to human transferrin and its uptake by K562 cells pot
... filter.RESULTSBinding of Yb3+ to apo-hTfThe thermodynamics of binding of Yb3+ to apoTf.Binding of Yb3+ to apo-Tf was investigated by addition of aliquots of Yb3+ to a solution of apo-TF in 100 ... study of uptake of Yb3+by human Tf (hTf) by UV-vis and NMR spectroscopy,and inductively coupled plasma atomic emission spectro-metry (ICP-AES). The binding of Yb-bound Tf to human erythroleukemia ... The X-ray crystal structure of Sm2-lactoferrin revealed that Sm3+indeed binds to twotyrosine residues in both lobes of the protein and induces theFig. 7. Saturation curve of binding of FITC-Fe2-Tf...
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Báo cáo Y học: Oxidation of propionate to pyruvate in Escherichia coli Involvement of methylcitrate dehydratase and aconitase pot
... methylcitrate into 2-methylisocitrate. PrpD is involved in the dehydration of (2S,3S)-methylcitrate to 2-methyl-cis-aconitate. The elimination of water from (2S,3S)-methyl-citrate to 2-methyl-cis-aconitate ... cycleenzyme, whereas AcnA is an anaerobic stationary-phaseenzyme which is specifically induced by iron and redoxstress [29].Interestingly, two enzymes are involved in the conversion of methylcitrate ... citrate cycle aconitase B is always involved in thehydration of 2-methyl-cis-aconitate to 2-methylisocitrate in the bacterial methylcitrate pathway. Some organisms, e.g.Ralstonia eutropha, seem to...
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Báo cáo y học: "Contribution of psychoacoustics and neuroaudiology in revealing correlation of mental disorders with central auditory processing disorders" ppt
... in the auditory cortex. One shouldkeep in mind that, understanding of the exact way of processing the auditory information at the level of the au-ditory cortex, is still incomplete. It is in ... contribution of auditory evoked potentials in the diagnosis of sensorineural hearing loss in infancy andearly childhood PhD Thesis. Aristotelian University of Thessaloniki,Otorhinolaryngologic ... fascinating field. Coopera-tion of professionals in psychiatry, neurology, neuropsy-chology and pediatric psychology, with theotolaryngologist-audiologist is a prerequisite. Central au-ditory...
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Báo cáo y học: "Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis" pdf
... discrepancy of cytokine synthesis in patients with RA versus HDs upon the influence of catecho-Figure 3Influence of catecholamines on cytokine ratios and intracellular interferon (IFN)-γ expression in ... examined by taking history, physical examina-tion, and laboratory findings (erythrocyte sedimentation rate,C-reactive protein [CRP], rheumatoid factor, anti-nuclear anti-bodies, hemoglobin, leukocytes, ... lymphocytes in peripheral blood was induced byEPI infusion in patients with RA and HDs [26]. The recruitment of IFN-γ-producing lymphocytes into the periphery rather thana true increase in cytokine synthesis...
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Báo cáo y học: "Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics" pdf
... previously described, staining of human synovial tissue withhaematoxylin and eosin showed an increase in the number of cell layers of the synovial lining of RA patients (Figure 1). E-cadherin staining ... Administra-tion of BMP-7 to healthy FLSs in vitro had no effect on α-smaFigure 1Haematoxylin and eosin staining on healthy and arthritic synovial tissueHaematoxylin and eosin staining on healthy and ... E-cadherin in syn-ovial tissue [29], our study is in line with a study by Trollmo andcolleagues [30], describing E-cadherin expression in the lininglayer of healthy synovial tissue, indicating...
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