Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot

... RNAi machinery is that RNAi was initially recognized as an antiviral mechanism in plants and certain invertebrates [14]. The evolutionary conservation of RNAi suggests a similar role for RNAi in mammals, which ... Although they were initially reported to be specifically associated with systemic lupus erythematosus [7], a later study showed that auto- antibodies to the Su antigen are...

Ngày tải lên: 09/08/2014, 08:22

... 204:2439-2448. 6. Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A 2007, ... 1667. doi:10.1186/cc8977 Cite this article as: Abraham E: Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Critical Car...

Ngày tải lên: 13/08/2014, 20:21

... precursors catalysed by PKH is required ubiquitously in mammalian tissues [15]. Decreased activity of PKH leads inter alia to a decreased availability of PLP for GAD, which cata- lyses the formation ... pyridoxal kinase and eventually oxidized by pyridoxine ⁄ pyridoxamine phosphate oxidase [7]. Both enzymes are part of the vitamin B 6 ‘salvage pathway’ (Fig. 2A) . PLP is then transpor...

Ngày tải lên: 07/03/2014, 10:20

... research literature. Thus, with regard to capability, we distinguished between physical and psychologica l capability (psycholo- gical capability being the capacity to engag e in the necessary ... and systems/BioMed Central 2008, 6:13. 27. Abraham C, Kok G, Schaalma H, Luszczynska A: Health Promotion. In The International Association of Applied Psychology Handbook of Applied Psychology...

Ngày tải lên: 10/08/2014, 10:23

... proteins. In addition to having a direct impact on HIV infectivity, many of these factors also mediate innate immunomodulatory activity and consequently have the potential to impact innate and ada ptive ... MJ, Pandrea I, Faye A, Onanga R, Apetrei C, Poaty- Mavoungou V, Rouquet P, Estaquier J, Mortara L, et al: Antiinflammatory profiles during primary SIV infection in African green monke...

Ngày tải lên: 13/08/2014, 01:20

... hematoxylin and eosin or Safranin O/Fast Green stain. Synovial tissue from tarsal joints was evaluated on the basis of synovial hyperplasia, fibroplasia, inflammatory cell infiltration, and pannus ... [3], an important role for acti- vated NF-κB in human RA is likely. α1-AGP = α1-acid glycoprotein; ANOVA = analysis of variance; CFA = complete Freund's adjuvant; ConA = concanavalin A...

Ngày tải lên: 09/08/2014, 06:22

... sufficient stability after cleavage by TEV protease and removal of the NusA tag for structural characterization by NMR. The quaternary states of NusA-HuR and NusA-RRM 3 were assessed by multi-angle ... on a Hi-Trap QP column (GE Healthcare, Piscataway, NJ) at pH 7.5 using a 0-1 M NaCl gradient. NusA-RRM 1&2 was further puri- fied on a Hi-Trap SP column (GE Healthcare, Piscataw...

Ngày tải lên: 12/08/2014, 23:23

... Biochemical characterizations of the mRNA polyadenylate binding protein (PABP) and the hnRNP protein C shed light on a consensus RNA- binding domain of approximately 90 amino acids containing a central ... the N- and C-terminal regions The N- and C-terminal regions of the RRM are often of crucial importance to dramatically enhance the RNA- binding affinity by increasing the...

Ngày tải lên: 19/02/2014, 17:20

... [47]. But the terminal extensions, although apparently not a determinant in the structural chemistry of present-day crystallins, may have instead had key roles in the evolu- tionary modular assembly ... structural elements to build up the interface. Hence, in c-type crystallins the interdomain hydrophobic patches may not be the only determinant for domain association, whereas...

Ngày tải lên: 24/03/2014, 04:21

... Inspection of the T. brucei databases identified several DNA sequences that code for a homolog of a PKA catalytic subunit. The catalytic activity of the immunoprecipitates was then analysed by incubation in ... of trypanosomal PKA. The coprecipitated kinase is recognized by an antibody against the bovine PKA catalytic subunit, the enzyme phosphorylates a PKA-specific substra...

Ngày tải lên: 31/03/2014, 23:20