Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx

... endocyto- sis and recycling. The cycling of Rab5 between the GTP and GDP forms may in uence the length and intensity of TGFb ⁄ activin signaling cascades by regulating TGFb–activin type I ⁄ II receptor ... phosphorylate and activate LIM-kinases 1 and 2, respectively [128–132]. Eventually, LIM-kinases 1 and 2 phosphorylate actin-depolymerizing proteins such as cofilin, destrin...

Ngày tải lên: 07/03/2014, 01:20

... Osada 2 and Hiroaki Kataoka 1 1 Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan 2 Department of Urology, Faculty of Medicine, ... proteins were extracted, and the processing of pro-HGF ⁄ SF was analyzed by immunoblot analysis. The migration capability of SUIT-2KLK5 cells was analyzed using pol...

Ngày tải lên: 23/03/2014, 07:20

... Ca 2+ ligating amino acids in the N-terminal part of the first EGF-like domain of factor X in uences the amidolytic activity of the intact protein [36]. However, direct interactions between the Gla and serine ... for binding intact factor X and Gla– EGF N (data not shown). Kinetics of membrane binding The kinetics of binding to PL membranes of the zymogen factor X, activated...

Ngày tải lên: 08/03/2014, 23:20

... Tremblay, R., Chakravarthy, B., Mealing, G., Morley, P., Small, D. & Song, D. (1997) Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced ... detect changes in the binding activity of the proteins recognizing specifically the )10 region of the PS1 promoter in nuclear extracts of SK-N-SH cells treated with TPA (Fi...

Ngày tải lên: 08/03/2014, 09:20

... ability of the wild-type dUSP and dominant negative, ligand-binding pocket mutant dUSP to bind methyl epoxyfarnesoate. In a ligand-binding assay that detects methyl epoxyfarnesoate binding through ... movement of the ligand-binding domain a-helix 12. Ligand-binding pocket point mutants of USP that do not bind methyl epoxyfarnesoate act as dominant negative suppressors of methyl ep...

Ngày tải lên: 23/03/2014, 21:20

... determined in kinetic assays. Catalytic calcium binding was determined in both wild-type OMPLA and the covalent OMPLA dimer in the kinetic assay, in which the mole fraction of substrate in the ... This strongly suggests that the type of substrate in uences dimerization thereby indirectly in uencing binding of the catalytic calcium for wild-type OMPLA. Subsequently, it was...

Ngày tải lên: 24/03/2014, 03:21

... prolongation in the answering and processing times of emergency calls in Helsinki, the capital of Finland [5]. EMCC organization and EMD in Finland - before and now There used to be 45 municipality-based ... handbook for drawing up an alarm procedure. Finland Helsinki; 2005, 56. 7. Kuisma K, Boyd J, Väyrynen T, Repo J, Nousila-Wiik M, Holmström P: Emergency call processing an...

Ngày tải lên: 25/10/2012, 10:02

... treatment, as shown by increased intensities of both shifted bands in hA-treated cells. In addition, the increased CRE binding activity was suppressed by JNK inhibitor I and SB 203580, implying that hA-evoked ... CRE binding is mediated by both the JNK and the p38 kinase pathways. Additionally, supershift assays (antibody pre-incuba- tions) were performed to determine which types o...

Ngày tải lên: 07/03/2014, 12:20

... Lu 3+ ,Sm 3+ and Eu 3+ ,respect- ively [34]. Both UV and ICP-AES data suggested that two Yb 3+ bind to apo-Tf in the specific iron binding site and two tyrosines are involved in binding of Yb 3+ in both ... with Band Pass (BP) filter and Long Pass (LP) 590 nm filter. RESULTS Binding of Yb 3+ to apo-hTf The thermodynamics of binding of Yb 3+ to apoTf. Binding of Yb 3+ to a...

Ngày tải lên: 08/03/2014, 09:20

... Analogously, GO and MSOX show a fairly similar activity o n s arcosine and N-ethylglycine. In contrast, an appreciable activity on glycine, glycine-ester a nd D -pipecolic acid was only observed using ... Comparison of the three-dimensional protein and nucleotide struc ture of the FAD- binding domain of p-hydroxybenzo ate hy droxy lase with the FAD- as well as NADPH-binding doma...

Ngày tải lên: 08/03/2014, 16:20