Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt

... for the analysis of gene function in many organisms in vitro and in vivo. In mammals, at present RNAi is mainly restricted to the analysis of easily transfectable cell lines in vitro, but here it ... knowledge of the mechanism of RNAi, the technical basis for its application to functional gene analysis in mammalian cells in vitro and in vivo, and potent...

Ngày tải lên: 09/08/2014, 01:23

... 2 Transient autoimmunity was induced in female C57BL/6 and actin-resistant, salt-resistant and hyperactive mutant of DNase I (ash .DNase I) mice by intraperitoneal injection with a single dose of ... and plasma in mice [17,18]. Impaired DNase I function has been implicated in the pathogenesis of SLE for many years since the initial observation that DNase...

Ngày tải lên: 09/08/2014, 07:20

... deviations. Data were analyzed by a nonparametric statistical analysis. An anal- ysis resulting in value of P < 0.05 was considered statistically significant. Results HIF-1α mRNA expression in ... HIF-1α with the deviating from adaptation to hypoxia. We postulated that HIF- 1α is expressed in response to catabolic change in articular cartilage to maintain the cell viabili...

Ngày tải lên: 09/08/2014, 06:23

... Metter A, Listing J, Sieper J, Braun J: Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis ... 279:51897-51907. 27. Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T: PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regula- The following Additional files a...

Ngày tải lên: 09/08/2014, 14:22

... Nanomedicine Research, National Health Research Institutes, Zhunan, Taiwan. 3 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. 4 Graduate Institute of Biomedicine and Biomedical Technology, ... proteomic profile and western blot analysis, the expression of LEG3 was exclusively increased in the injured spinal cord at day 14 post SCI, implying that active pha...

Ngày tải lên: 10/08/2014, 05:21

... characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study. Urology 2005, 66:935-940. Journal of Inflammation ... inflammation and induction of healing and in the bladder. Our results therefore argue in favor of evaluating urinary TGF-β1 in IC patients in order to assess diseas...

Ngày tải lên: 11/08/2014, 08:22

... of the native oxidase. In focussing on the main interaction domain on subunit II, we introduced additional mutations in exposed residues in the relevant area above the Cu A site (see Fig. 1 and Table ... functional binding site: Several attempts to eliminate a hypothetical second site have been made here for the bacterial enzyme by stripping subunits III and IV off...

Ngày tải lên: 22/02/2014, 07:20

... This raises the possibility that any one or a combination of these properties may in uence the binding of apolipoproteins to lipoprotein particles. The capacity to fractionate lipid emulsions into ... lipid particles, are notably distinct in their maximum binding capacities (Table 2). In particular, the binding footprint for the apoE4 isoform, corresponding to 3.0 amino a...

Ngày tải lên: 08/03/2014, 09:20

... cytosolic isoenzyme. In fact, under conditions where the cytosolic AAT was stable, there was a thermal instability of mitochondrial AAT at 70 °C [22]. The activity of mitochondrial AAT was taken ... inhibited by the addition to the mitochondrial suspension of CsA (Fig. 5A) , the specific inhibitor of the permeability transition pore of mitochondria [26]. This change...

Ngày tải lên: 24/03/2014, 04:21

... mention the diagnostic methodology and a classification of CRS. CRS is primarily a clinical diagnosis based on history and physical examination. The physi- cal examination of the sinusitis patient ... cell) Agger nasi air cell Advances in Surgical Management of Rhinosinusitis — Wright and Frenkiel 25 Perhaps the most significant and exciting innovation in the a...

Ngày tải lên: 08/08/2014, 20:23