Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... the synovial lining is where TGF- β induces synovial fibrosis, by co-transfection with Smad7, the lining appeared tobe less sensitive to TGF- β-induced fibrosis. The reduction of TGF- β-induced fibrosis ... deal of the TGF- β-induced synovial fibrosis. Combining Smad7 and TGF- β resulted in a higher PG synthesis after IL-1 insult thandid TGF- β alone. This is likely due to the reduced synovial fibrosis ... every single one of the synoviallining cells and thereby fully block the TGF- β-induced fibrosis. We have previously demonstrated that blocking TGF- β withAd-Smad7 in OA resulted in reduction of...
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Báo cáo y học: " Isolated radial head dislocation, a rare and easily missed injury in the presence of major distracting injuries: a case report" ppsx
... injuries,an isolated radial head dislocation can be easily missed aspain is masked by the presence of major distracting inju-ries and flexion and extension of the elbow is normal. Ifsupination ... reviewing the literature and drafted the manuscript as the mainauthor.RSUY was involved in reviewing the literature and proofreading of the manuscript. RSUY has approved the finalmanuscript.SSB is ... and splints applied to bothknees.12 hours later, the patient complained of pain in the rightelbow. There was no previous history of elbow injury orarthritis. On examination, there was minimal...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... structurally similar but enzymatically inactive (DPP6, DPP10). In some instances, the DPPIV activity is clearly intrinsic whereas in others the nature of the DPPIV activity remains debatable. In these ... carefullyregulated without disturbing the overall immune homeostasis, the presence of systemic activated T cells will lead to theircontinuous influx into the inflamed synovium, maintaining the inflammatory ... cells infiltratinginto the synovium from the periphery. This concept stresses the kinetic nature of synovial inflammation where a single timepoint assay may identify a synovial population of CD26low‘spent’...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... inflammatory response in the lungs of mice which is linked to a reduction in HDACactivity and may be a key mechanism of glucocorticoidinsensitivity in COPD [11,17,21]. Both this reduction in HDAC ... complexes or their role in disease. The reduction in mSin3a expression in the lungs of cig-arette smoke-expose mice may reduce the capacity for the regulation of pro-inflammatory genes. In addition,cigarette ... of key compo-nents of the transcriptional machinery including the corehistone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed con-formation...
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Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx
... reliability of the cod-ing by refining the conten t boundaries of the code s andmaking coding more consistent. An audit trail was kept in NVivo. At the end of the data collection and analysis, the ... following instruction appears to be ingrained in their reasoning for bringing in the letter. These indivi-dualsstatedtheyweresimplydoingwhattheletterrequested of them.‘For one thing I was ... participating in the study and forbring ing in the letter for discussion. For sev eral patientsit was their way of ‘paying back’ the military and otherveterans, while othe rs were merely ‘following...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... complexes or their role in disease. The reduction in mSin3a expression in the lungs of cig-arette smoke-expose mice may reduce the capacity for the regulation of pro-inflammatory genes. In addition,cigarette ... ourunderstanding of the roles of these co-repressor com-plexes and thereafter their roles in disease. In summary cigarette smoke exposure reduced HDAC-2 activity and the expression of mSin3a and Mi-2α in ... machinery including the corehistone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed con-formation [1,16].HDAC-2 function is impaired by...
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Báo cáo y học: "Clozapine-induced interstitial nephritis – a rare but important complication: a case report" ppt
... and the development of interstitialnephritis. In this case, the patient had been previouslyexposed to clozapine and the rapid onset of the reactionafter just five doses of clozapine is consistent ... by, lithium carbonate. Given the severe and refractorynature of the patient’s condition, and taking into account the circumstances of the previous trial of clozapine, thereappeared compelling ... initiated.Clozapine was started with a dose of 12.5 mg at night. Onday 2 of clozapine treatment (12.5 mg in the morning andat night), the patient complained of feeling generallyunwell and on examination...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... EMSAs.N-terminal sequencing of the 70-kDa protein was inhibitedby modification, consistent with previous reports showingthat the amino terminus of the human Ku-70 protein is blocked and therefore inaccessible ... determine whether the MREa–protein complex displays sequence specificity. Binding of the HepG2 nuclear proteins to MREa was inhibited by the addition of a molar excess of unlabelled MREa to the binding ... are indicated at the left of each panel. The purified protein bands are indicated by solid arrowheads.Fig. 4. Microsequencing analysis of the MREa-binding proteins.(A) The N-terminal sequence of...
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Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx
... domain binds strongly to importin a and the bind-ing is diminished or eliminated even if only one of the twobasic stretches are mutated. The affinity of the importin-targeting sequence interaction ... binding to importin b causes the disso-ciation of the import complex and release of the cargo[10,11]. The directionality of the nuclear import is conferredby an asymmetric distribution of the ... clearlysupport the hypothesis that importins a might be specialized in their efficiency to transport different nuclear proteins [59].It will be interesting to analyze the binding specificity of the different...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... detected in the syn-ovial lining cells by in situ hybridization in our study. Anotherexplanation is the difference of types of RA. The distribution of IL-32 expression in synovial tissues may be ... proinflammatory cytokine related to the pathogenesis of inflammatory diseases such as RA and IBDs[5,6,11]. The precise mechanism of TNFα induction in the inflammatory diseases, however, is still ... synovium and the intestinal epithelium. In thisway, IL-32 has a close relationship with the proinflammatorycytokines, especially TNFα, and this relationship may be one of the main mechanisms by which...
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Từ khóa: báo cáo khoa học y họcbáo cáo y họcbáo cáo y học cổ truyềnbáo cáo y tế học đườngmẫu báo cáo y tế học đườngBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật