Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... taken (inset). The arrowhead in the inset indicates COMP staining. (f) At gw 12, COMP staining is found in the outer regions of the diaphysis and is mainly pericellular (inset). Bars = 70 µm in ... localization of cartilage oligomeric protein (COMP) during early human bone and joint developmentLight microscopic localization of cartilage oligomeric protei...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... levels of antibodies against cartilage oligomeric matrix protein and collagen II Antibody levels against COMP in serum were analyzed by enzyme-linked immunosorbent assay (ELISA) using recom- binant ... leading to arthritis. In the chronic stage of the disease, when the erosion of the cartilage is taking place, it is possible that immune reactions to other cartil...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... tract-binding protein (PTB) is a widely expressed RNA- binding protein with multiple roles in RNA processing, including the splic- ing of alternative exons, mRNA stability, mRNA localization, and internal ribosome ... cells are established from the inner cell mass (ICM) of blastocysts. ES cells are defined by their ability to give rise to a variety of mature progeny while m...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast docx
... eukaryotic pro- tein biosynthesis by binding aminoacyl-tRNAs and positioning them in the A site of ribosomes. However, the cytoplamic Leishmania EF-1a binds the host’s Scr- homology-2-containing ... is well studied; it involves many RNA–RNA, protein RNA, and protein protein interactions. In contrast, know- ledge about the process of protein synthesis in Trypan- os...
Ngày tải lên: 23/03/2014, 10:20
Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
... organs. 9 The purpose of this study was to evaluate the safety and efficacy of oral Apatone administered throughout the day in prostate cancer in patients who failed standard therapy. Int. J. ... administered to human tumor cell lines, including androgen independent prostate cancer cells (DU145), they exhibited a synergistic inhibition of cell growth and induced...
Ngày tải lên: 08/08/2014, 17:20
Báo cáo y học: "Leveraging a clinical research information system to assist biospecimen data and workflow management: a hybrid approach" pptx
... com- panying description/explanation) is created at the foot of the page. Clicking the button executes the URL, which takes a single parameter, the symmetrically encrypted primary-key value of the ... management of longitudinal clinical studies invol- ving biospe cimen collection and analysis, integration of the capabilities of a CRIS and BDMS can offer signifi-...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps
... was injected intra-articularly into murine knee joints, which were isolated 3, 7, and 21 days after injection for histology, immunohistochemistry, and autoradiography. In addition, patellar and ... [24,25]. In this study, BMP-2 induced an increase in mRNA levels of collagen type II and aggrecan and stimulated proteoglycan synthesis up to three-fold in vivo, both in healt...
Ngày tải lên: 09/08/2014, 10:21
Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... measuring sulphated glycosaminoglycans (S-GAGs) are available, these assays do not distinguish between synthesis and degradation of the pro- teoglycans [19]. Furthermore, they do not distinguish ... antibod- ies in a sandwich ELISA system. The BC3 antibody (Abcam plc, Cambridge, UK) is used as the capturing antibody and the other antibody, F78, recognizes epitopes in the...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... of the DNA damage sensing protein ATM and ATR, (34, 35). The involvement of the DNA damage repair pathway in NS1-induced apoptosis was examined in GFP/NS1-transfected cells by treat- ing the ... DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, we found that NS1 covalently binds to cellular DNA and is modified by PARP, an enzyme i...
Ngày tải lên: 25/10/2012, 11:18
Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot
... many cell cycle proteins such as cyclinD1, D3 and A [6,7]. It is not known, however, which of these phenomena are direct or indirect effects of progesterone and what is the role of progestin-induced ... of the G-proteins in progestin-mediated signaling is also highligh- ted by a study showing that half of the progesterone- regulated genes were involved in membr...
Ngày tải lên: 24/03/2014, 00:21