Báo cáo y học: "B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren''''''''s syndrome" ppt
Báo cáo y học: "B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren''''s syndrome" ppt
... 2Immunocytochemical analysis of salivary epithelial cellsImmunocytochemical analysis of salivary epithelial cells. Cells were obtained from minor salivary glands (a–e) and the HSG cell line (f–i). ... of 9(page number not for citation purposes)Vol 8 No 2Research articleB cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary ... staining for cytokeratin 7 (a) and cytokeratin 19 (b) and the absence of staining with cytokeratin 20 (c) indicates the specificity of ductal epithelial cell origin. The absence of staining...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... detected in the syn-ovial lining cells by in situ hybridization in our study. Anotherexplanation is the difference of types of RA. The distribution of IL-32 expression in synovial tissues may be ... synovium and the intestinal epithelium. In thisway, IL-32 has a close relationship with the proinflammatorycytokines, especially TNFα, and this relationship may be one of the main mechanisms by which ... of IL-32 is expressed in the synovial membranes of RApatients, because the sensitivity of in situ hybridization is lim-ited [50]. In the previous study, the synovial lining cells of RApatients...
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Báo cáo y học: "Use and knowledge of the razor-billed curassow Pauxi tuberosa (spix, 1825) (galliformes, cracidae) by a riverine community of the Oriental Amazonia, Brazil." pdf
... encounters with the bird,but their failure in capturing it. All interviewees statedthat their criterion for the choice of a prey is its size,and that they only hunt juveniles by mistake. They alsoreport ... rev-enue. The activities of hunting and fishing are alsoimportantfortheirsurvival,sincetheyprovidearichsource of animal protein. Family based farming is alsopart of this group of activities, ... The use of the P. tuberosa feathers as a domestic toolrepresents another ecosystem service important to the lives of the riverines and thepresenceofthesetoolsinevery visited house may be...
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Báo cáo y học: "Anorectal stenosis after treatment with tumor necrosis factor a antibodies: a case series." doc
... widely used in the treatment of chronic inflam-matory bowel disease (IBD). TNF-a is a proinflamma-tory cytokine that plays a central role in the pathogenesis of IBD. Currently, infliximab is ... mucosal healing. This in turn led to anorectal stenosis. This is the first report of this complication in association with the use of biologic agents.Introduction Tumor necrosis factor a antibodies ... draining perinealsinus. He was treated initially with a combination of steroids and subsequently maintained in remission withazathioprine. He has no other medical or surgicalproblems.His disease...
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Báo cáo y học: "A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pdf
... therebyappearing to be natural settings for these types of investi-gations. Evaluation of these and other transformativestrategies may be slightly different than historical interest in clinical ... performance indexcreated by the authors that was the percent of completions in a month minus the baseline target of 80%. This studyillustrates why outcome measurements in these types of evaluation ... than the other Six Sigma studies in terms of external validity. In spite of this strength, they still bothshare many of the same limitations and concerns, asnoted above. In the case of the hand...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... activation of gp130 by formation of disulfide bonds [30]. The analysis of cysteine residues in gp130 led to the finding that the two N-terminal cysteines of D5 (C458 and C466) form an intramolecular disulfide ... which is positioned by the disulfide bondbetween cysteines C458 and C466 [30].To analyse the role of the three cysteines in D5 of gp130 in heterodimerization with the LIFR, each of the cysteineswas ... single domain in the membrane-proximal part of gp130leads to a shift of the receptor areas involved in ligandbinding closer to the membrane, resulting in the inability of the receptor chains...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... to the EGF receptor. A deletion in the N-terminal region of domain I impaired the EGF binding of ErbB-1 [21]. The N-terminus of EGF was linked to Tyr101 in domain I by using a covalent cross-linking ... [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of the receptor. Recently,Gly441 of the ErbB-1 domain III was proposed to beinvolved ... of ERKactivation resulting from the amplifying effect of the signaling cascade.DISCUSSION In the present study, by using chimeric receptors, the contributions of the extracellular domains of...
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Báo cáo y học: "Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals" doc
... proteinsynthesis, cycloheximide. Inhibition of new protein synthe-sis is necessary, since IκB proteins are degraded as part of the signaling pathway and NF-κB activity itself inducesnew protein synthesis ... abnormalities completely using primary lymphocytes. The development of technology to employ intracellular staining and flow cytometryto assess the signaling status of individual cells has now made ... phosphorylation of cellular proteins in whole cells by flow cytometry. Cytometry 1994, 15:327-334.2. Far DF, Rossi B: Measurement of protein tyrosine phosphory-lation in T-cell subsets by flow cytometry....
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Báo cáo y học: "Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis" pptx
... plays a central role in the pathogenesis of CIA in IFN-γR KO mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4+ cells to the ... apro-inflammatory factor in the pathogenesis of autoimmunearthritis by attracting inflammatory cells to joints and by stimulating the differentiation and activation of osteoclasts.IntroductionAmong ... of the CIA treatment, occurring for example by inhibition of leukocyte infiltration in the joint.Furthermore, we investigated the possibility that CXCL12 caninduce production of RANKL and thereby...
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Báo cáo y học: "Increased serum levels of macrophage migration inhibitory factor in patients with primary Sjögren''''s syndrome" potx
... the original work is properly cited.Abstract The objective of this study was to analyse levels of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) in patients with primary ... lipopolysac-charide in sepsis. In pSS, MIF apparently has no inducingeffect on TNF-α or other proinflammatory cytokines analysed,presumably because of a lack of such co-stimulatory factors. The ... correlation with the disease activity in patientswith systemic lupus erythematosus.Recent findings suggest that MIF might participate in the pathogenesis of other diseases of connective tissue. The present...
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