Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)" ppt

... Synthesis of the PNA building block backbone In the next step, the synthesis of the PNA back- bone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occurred as described by Atherton ... cysteine is attached at the amino terminus of the PNA backbone 4 Solid phase synthesis of the “Reppe anhydride” -PNA pentamer. To perform the solid phase...

Ngày tải lên: 26/10/2012, 08:57

... from septic iNOS + ⁄ + mice, a find- ing related to the i-mtNOS induction, because iNOS – ⁄ – mice did not show changes in LPO levels. Mitochondrial GPx activity increased in iNOS + ⁄ + mice, ... was lower in iNOS – ⁄ – than in iNOS + ⁄ + mice (Fig. 3A). The mitochondrial level of GSH decreased and that of GSSG increased in hearts from iNOS + ⁄ + mice after CLP (Fig...

Ngày tải lên: 19/02/2014, 00:20

... 2002 Characterization of the exopolysaccharide produced by Streptococcus thermophilus 8S containing an open chain nononic acid Elisabeth J. Faber, Daan J. van Haaster, Johannis P. Kamerling and ... composition of the EPS produced by S. thermophilus 8S, the genetics and biochemistry of the EPS biosynthesis as well as the physical properties of...

Ngày tải lên: 08/03/2014, 09:20

... article Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti -TNF protocols Eleni Douni 1 , Petros P Sfikakis 2 , Sylva ... efficacy of diacerein in preventing the development of pathology in the Tg197 transgenic murine model of RA, in which inflammatory pol...

Ngày tải lên: 09/08/2014, 01:23

... disor- der of unknown aetiology, characterized by intimal lining layer hyperplasia, infiltration of the sublining area by macrophages, T and B lymphocytes, plasma cells and other inflammatory cells as ... article Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator o...

Ngày tải lên: 09/08/2014, 07:20

... feelings of hopelessness and despair that may develop after starting treatment with an antidepressant [12] that may lead to suicidality. The clas- sical action of the reserpin can serve as a model ... presence of an SSRI can lead to a reduced activity of serotonin-mediated neuronal activity possible related to abnormal behaviour such as suicidal ideation. Unfortunatel...

Ngày tải lên: 11/08/2014, 10:23

... health monitoring of patients with schizophrenia. Am J Psychiatry 2004, 161(8):1334-1349. 14. American Diabetes Association, American Psychiatric Association, American Association of Clinical ... primarily due to cardiovas- cular disease [8]. Second-generation antipsychotics (SGA) or atypical drugs have gained widespread acceptance for the management of patients with schiz...

Ngày tải lên: 11/08/2014, 17:20

... saline (negative control) only; B. Injection with bleomycin only on Day 0; C. Injection with bleomycin on Day 0 and SPARC siRNA on Days 2, 5, and 12; D. Injection with bleomycin on Day 0 and ... A. Injection with saline (negative control) only; B. Injection with bleomycin only; C. Injection with bleomycin and treatment with SPARC siRNA; D. Injection with bleomycin...

Ngày tải lên: 12/08/2014, 12:20

... Key words: chemokine receptor, CXCR3, CD8+ T lymphocyte, airway inflammation, airway hyperresponsiveness 12 predominant cell types were macrophages, lymphocytes, and eosinophils ... in response to increasing 1 Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice Yi Lin 1 *, Haibo Yan 2 *, Yu Xiao 3...

Ngày tải lên: 12/08/2014, 14:20

... bleomycin 6 in bleomycin6 in bleomycin 6 in bleomycin- -induced lung induced lung induced lung induced lung inflammatory changes in mice inflammatory changes in miceinflammatory changes in mice inflammatory ... bleomycin bleomycinbleomycin bleomycin- -induced pulmonary inflammation in the rat induced pulmonary inflammation in the ratinduced pulmonary i...

Ngày tải lên: 12/08/2014, 14:20

... importance of CXCR3 in CS -induced lung inflammation by using CXCR3 KO mice. In conclusion, our study shows that CXCR3 regulates CS -induced lung inflammation via recruitment of CD8+ T cells into the lung ... of CXCR3 gene in mice significantly prevented the lung inflammation induced by exposure to CS. CXCR3 may be a key factor in CS -induced pul...

Ngày tải lên: 12/08/2014, 14:20

... activa- tion of lysine hydroxylase and hydroxylysine glycosyltransferase, allowing partial glycosylation of the product. This system closely mimics the post-transla- tional system of mammalian ... the original work is properly cited. Research article Modulation of collagen- induced arthritis by adenovirus-mediated intra-articular expression of modified collagen typ...

Ngày tải lên: 12/08/2014, 14:22

... involved in the study. JPM partici- pated in the study design and coordination. BB supervised the study, and participated in its design and coordination. All authors read and approved the final manuscript. Acknowledgments We ... approxi- mately 4 days compared to the wt virus. Replication of the Q591L mutant was significantly better, with a delay of only one day co...

Ngày tải lên: 13/08/2014, 13:20

... Domburgh et al.: Correlates of self-reported offending in children with a first police contact from distinct socio- demographic and ethnic groups. Child and Adolescent Psychiatry and Mental Health 2011 ... migration stress, but also from the migration stress of their parents as stress may lead to inadequate parenting, and from the family van Domburgh et...

Ngày tải lên: 13/08/2014, 18:22

... effect of regionalization upon the quality of trauma care as assessed by concurrent audit before and after institution of a trauma system: a preliminary report. Journal of Trauma- Injury Infection ... Steen PA: Assessing quality of care in a trauma referral center: benchmarking performance by TRISS-based statistics or by analysis of stratified ISS data? Journal...

Ngày tải lên: 13/08/2014, 23:20