Báo cáo y học: "Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro" pps

... inflammatory mediators known to dominate the effector phase of CIA. Both arthritogenic and non -arthritogenic mouse mAbs to CII were shown by immun- ofluorescence to penetrate cartilage and bind strongly ... cited. Abstract Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on cho...

Ngày tải lên: 09/08/2014, 06:23

... and clinical monitoring, how to interpret and respond to laboratory results, management of adverse events, drug interactions, treatment and prophylaxis of opportunistic infections, * Correspondence: ... steady increase in the number of calls to the hotline since its inception, with over 300 calls per month in May 2010. During the two months of the st udy, 511 calls were rece...

Ngày tải lên: 10/08/2014, 05:21

... selectively modulated proin- flammatory cytokine gene expression in vivo. Only one gene, IL-6, was modestly suppressed which contrasts with many in vitro studies suggesting anti-inflammatory effects of ... Inhibition of the expression of inducible cyclooxygenase and proinflam- matory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinas...

Ngày tải lên: 11/08/2014, 08:21

... with the Poly [ADP-ribose] polymerase (PARP) inhibitor ABT-888 (final concentration 5µM) Recombinatory chemistry of the fusion plasmid The construction of the pKillerRed-Lamin B1 vector is carried ... Luo Y, Chang CK, Kessel D. Rapid initiation of apoptosis by photodynamic therapy. Photochem Photobiol. 1996; 63: 528-34. 53. Taub DD, Murphy WJ, Longo DL. Rejuvenation of the agi...

Ngày tải lên: 25/10/2012, 11:15

... thus may be a contrib- uting factor to the increase in B cells, both in total number and in maturity, within the thymus. The increase in B cell numbers in the thymus with age seems too small to ... thymus, involution, aging, microarray, AGEMAP, thymocytes, caloric restriction Introduction The aging immune system is often characterized by a general decline in the ability t...

Ngày tải lên: 03/11/2012, 11:35

... rmcelhan@gpu.srv.ualberta.ca Abbreviations: GS, gramicidin S; Myr 2 Gro-PCho, dimyristoylglycerophosphocholine; Myr 2 Gro-PEtn, dimyristoylglycerophosphoethanolamine; Myr 2 Gro-PGro, dimyristoylglycerophosphoglycerol; DSC, ... Ronald N. McElhaney 1,2 1 Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; 2 Protein Engineering Network of Centers of Excellence,...

Ngày tải lên: 21/02/2014, 01:21

... deficiency in organized PLB. The ability of the PLB to form a bicontinuous cubic phase is linked to the high proportion of the nonbilayer forming lipid monogalactosyldiacylglycerol (MGDG) pre- sent in ... photoconverted enzyme occurring under these conditions to be inhibited by ATP and by the protein phosphatase inhibitor NaF. On the basis of this study, and subsequent studie...

Ngày tải lên: 22/02/2014, 04:20

... The enzymic incorporation of arachidonic acid into ether-containing choline and ethanolamine phosphoglycerides by deacylation-acylation reactions. Biochim. Biophys. Acta 326, 26–33. 51. Yamashita, ... radioactivity imaging system (Washington, DC, USA) and the amount of radioactivity migrating with PAF was determined by zonal scraping, followed by liquid scintillation counting. Determinati...

Ngày tải lên: 22/02/2014, 07:20

... infiltration, stimulation of glycosaminoglycan release and nitric oxide production, and induction of fibrogenesis and muscle edema. In addition, induction of chondrogenesis within the synovial lining ... stimula- tion in the production of proteoglycans [9]. In addition, we have demonstrated that the TGF-β1 gene was able to overcome the inhibitory effects of IL-1β on matr...

Ngày tải lên: 09/08/2014, 01:21

... have anti-inflammatory proper- ties depending on the timing of TNFα expression in a murine model of autoimmune diabetes [9]. One possibility to consider is that TNFα acts on cells of the joint (for ... potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998, 4:78-83. 6. Kassiotis G, Kollias G: Uncoupling the proinflammatory from the immunosuppres...

Ngày tải lên: 09/08/2014, 10:23