Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... 1).
Role of IL-17 in T cell immunity and/or
propagation of joint inflammation
In arthritis, IL-17 is a pro-inflammatory cytokine thought to
contribute to the joint inflammatory process [38]. Studies
in ... target
for the treatment of destructive arthritis. Because it is
known that this T cell factor can have synergistic effects
with catabolic/inflammatory mediators, it...
Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... cytokines and chemokines that attract leu-
kocytes to the site of infection and trigger the maturation
and trafficking of antigen presenting cells for induction
of adaptive immunity (figure 1). The ... by host pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), elicits innate
immune responses that subsequently instruct adaptive immunity. Recovery from the incit...
Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... With this in mind, it
could be interesting to investigate whether the accumu-
lated T
reg
cells in patients with arthritis function properly in
vivo and whether these patients could really benefit ... might be too late to
inhibit activation of effector T cells and their migration to the
joint. Indeed, T- cell activation is an early event in AIA
because CD4
+
T cell deple...
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... Forward GTATTCAAAAGTGGTCCCGGACAAAATGAG GACTTG
Reverse TCCGGGACCACTTTTGAATACTTTCAAGTGCATATATTTATT
P74G Forward CAAAAGTCTTGGCGGACAAAATGAGGACTTGGTAC
Reverse CATTTTGTCCGCCAAGACTTTTGAATACTT TCAAGTGC
Q76G ... contains three
domains resembling family 2 cystatins.
Cystatins competitively inhibit the activity of papain-
like cysteine proteases by binding to the active site of the
latter and formin...
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the hydrophobicity of the binding site.
To test the effect of the mutations on the specificity ... the
phenylalanines in the active site suggesting that hydropho-
bic interactions between the aromatic phenylalanines and
the phenyl ring of the substrate play an important role in
sub...
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... mutants still bind
coenzyme M and exhibit some activity although in both
mutants the coordination of zinc differs from the situation
in the wild-type enzyme. Apparently, other ligands to zinc
(H
2
O ... revealed by the crystal structure [19]. Zinc
thus can be quite differently coordinated and still activate
thiol groups for alkylation. Consistent with the interpreta-
tion is our findin...
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... [12,13]
suggest that correct orientation of the penicillin substrate
with respect to the putative high-energy ferryl intermediate
is important for optimum coupling between 2-oxoglutarate
and penicillin ... peni-
cillin substrates is a desirable objective, as this may allow
fermentation of starting materials for production of semi-
synthetic cephem antibiotics. The results in this pape...
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... others. The type of probi-
otic product was different as well as the timing of the
introduction of the probiotic, Taylor et al administered
the probiotic supplement postnatally, while other studies
administered ... [21].
Probiotics can potentially modulate the toll-like receptors
and the proteoglycan recognition proteins of enterocytes,
leading to activation of dendritic cells and a...
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... of
these kinds of prospective study, it is tempting to trans-
late animal data to our management of patients. However,
before doing this, certain points must be considered.
Most of the studies in ... repair
process.
Another point relates to the use of indomethacin in the
inhibition of heterotopic ossification in patients who have
sustained a pelvic fracture. These patients...
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... and two transactivating domains, namely the
amino-terminal transactivating domain and the carboxyl-
terminal transactivating domain (C-TAD). The C-TAD has
been shown to interact with co-activators ... (involved in the maintenance of
cells in an undifferentiated state), both of which notably
contain ankyrin repeat motifs containing the asparagine
residue hydroxylated by FIH [31]. Anoth...