Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx

... the time course study in the streptococcal cell wall (SCW)-induced arthritis in Lewis (LEW/N) ratHeat map diagram of differential gene expression in joints from the time course study in the streptococcal ... calculated by divid- ing the mean intensity signal from all the individual SCW- injected rats included in each group by the mean intensity signal from t...

Ngày tải lên: 09/08/2014, 06:22

... analysis. The reason may be due to a systemic error on the microarr ay analysis. Interestingly, unlike the result from Molt-4 cells, the alteration of the CREBBP expression level in primary T-All ... reported achangeinCREBBP expression in T cell lines after BCL11B-siRNA treatment. In the present study, downre- gulation of CREBBP was identified in the microarray...

Ngày tải lên: 10/08/2014, 21:23

... baseline depending on response to therapy, we performed immunostaining experiments on the synovial biopsy specimens obtained from the 25 patients included in the study. We evaluated the synovial expression ... significantly overexpressed at baseline in poor responders are induced by several cytokines in FLSs, thereby suggesting a role for these cytokines in the resistance...

Ngày tải lên: 09/08/2014, 14:20

... arthritis (RA), the gene expression profile is extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune disease [1- 5]. The ... high-density oligonucleotide arrays interrogating the entire mouse genome. Arthritis was induced in severe combined immunodeficient mice by using adoptive transfer of ly...

Ngày tải lên: 09/08/2014, 06:22

... of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leuko- cyte infiltration and synovitis in rabbit joints. Lymphokine Cytokine ... IL-17-induced inflammation and joint damage, implying a pathway independent of IL-1 [40]. The interaction of the cytokines IL-1β, IL-17, and TNF-α sus- tained inflammatory processes within...

Ngày tải lên: 09/08/2014, 01:22

... activity as measured by the SLEDAI, reinforcing the hypothesis that the IFN signature is a measure of disease activity or severity [16]. Inspection of gene expression data generated in our study of ... While early studies using this approach were largely in oncology, many new reports are emerging in other fields including infectious diseases and pharmacology, and applications...

Ngày tải lên: 09/08/2014, 01:23

... glycosidase activities in RA joints were probably not due to enhanced gene expression of resident SFs, but rather resulted from enzyme release by cells (including infiltrating inflammatory cells) within the joints. Competing ... [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, pro...

Ngày tải lên: 09/08/2014, 14:20

... β 1 /β 2 integrins, P-selectin is the predom- inant adhesion molecule, mediating monocyte binding to inflamed synovial venules [23]. Similarly, increased cellular infiltration and increased expression ... circulating leucocytes, and their interaction with the endothelial lining followed by subse- quent transendothelial migration and infiltration into tissue rep- resent the first and...

Ngày tải lên: 09/08/2014, 06:23

... especially focusing on clinically relevant endpoints like radiation induced cell death, proliferation, migration and metastasis. Introduction MicroRNAs are small non-coding RNAs of typically 20 - 22 ... significant changes in microRNA expression profiles in 3 glioma and 3 squamous cell carcinoma cell lines. The functional relevance of these changes is not addressed but should...

Ngày tải lên: 09/08/2014, 09:20

... renal tissue injury Renal tissue injury was evaluated using activity and chronicity indices as previously reported by Austin and colleagues [34]. The activity index was the sum of the scores (on ... nephropathy, postpartum renal failure, preeclampsia, HIV infection, or cyclosporine therapy [6,8]. The patients were informed of the purpose of the study and gave their informed cons...

Ngày tải lên: 09/08/2014, 14:21