Báo cáo khoa học: "Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40" ppsx
Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf
... similar to that in Asp141 of Met8P.The idea of NirF being a dehydrogenase is appealingbecause of the presence of a putative nucleotide-bind-ing motif in the N-terminal of the protein sequenceand ... to seek accu-mulation of the substrate of NirF in a mutant that lacks NirF; this too is not trivial as the DnirF straindoes not accumulate readily detectable amounts of anintermediate of d1synthesis.Experimental ... the proximal axial ligand to the d1 heme. Replacement of an equivalent His, His41, in NirF byAla abolished binding of the heme to the protein. Known distal heme- binding residues, such as Met,...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... (2006) Lung adenocarcinomasinduced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. GenesDev 20, 1496–1510.5 ... Ito F (2009) Mito-gen-activated protein kinase phosphatase-1 modulatedJNK activation is critical for apoptosis induced byinhibitor of epidermal growth factor receptor- tyrosine kinase. FEBS J ... show evidentanticancer effects in patients with non-small cell lung cancer (NSCLC) [6–8]. Beneficial responsiveness to these EGFR-targeting tyrosine kinase inhibitors (TKIs) in patients with...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... compilation ê 2010 FEBS 3173 Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen Christian ... transfected with a full-length furin cDNA, werepermeabilized and stained with polyclonalantibodies against furin and GRASP55.Arrows show examples of membranecompartment containing GRASP55 and furin. ... protein GRASP55 in the furin- dependent activation of MT1-MMP. MT1-MMP and furin were found to co-localize with Golgi reassembly stacking protein 55 (GRASP55). Further analysis revealed that GRASP55 associated...
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein Ilaria Sambi1, Pietro Gatti-Lafranconi1*, Sonia Longhi2 and Marina Lotti11 Dipartimento ... with a forward primer (5Â-TACCTGGCCAATGAATATGCATCATCATCATCATCATACTCCGTCGACCCCACC-3Â) designed to introduce a hexahistidine tag and a ClaI restriction site at nucleotideposition –6 and a reverse ... structural impact was obtained by averaging thecontent of a- helices, b-strands, b-turns and unorderedregions of the individual intrinsically unstructured proteins and GFP moieties.Analytical gel...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... are also interesting with regards to brain vas-culature, because they regulate the formation and main-tenance of BBB, modulate neurovascular coupling and maintain several parts of brain homeostasis. ... origin [78]. According to the monocytehypothesis, during embryogenesis, and even in adults,migrating monocytes enter the brain via blood vessels and then differentiate into certain types of brain ... once they inducenew vessel formation in areas lacking oxygen and nutrients. New vessels then undergo maturation stepssuitable for their environment. Vessel maturation in the brain involves the...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
... VEGF-D, binds and activates thisreceptor, resulting in the proliferation and migration of lymph ECs and lymphangiogenesis [13]. Angiogenesis in brain diseases Brain strokeStroke is induced through: ... amongtissues in the body, and the risk of edema to brain functions should be carefully considered. Brain edemamay increase pressure in the cranial cavity and brain tissue, resulting in suppression of ... (1994) Vascular endothelial growth factor and gli-oma angiogenesis: coordinate induction of VEGF recep-tors, distribution of VEGF protein and possible in vivoregulatory mechanisms. Int J Cancer...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx
... MINIREVIEW Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke Ken Arai, Guang Jin, Deepti Navaratna and Eng H. ... whether neurovascular responses after stroke can be reinter-preted in the context of angiogenesis in the brain. Is itpossible that some of the acute neurovascular events in the brain after stroke ... attemptby the brain to prepare the substrates necessary for angiogenesis and recovery? In this minireview, we sur-vey a few key events in the neurovascular unit, includ-ing blood brain barrier...
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Tài liệu Báo cáo khoa học: Catabolite repression in Escherichia coli – a comparison of modelling approaches docx
... activates adenylatecyclase (CyaA) and leads to an increase in the intra-cellular cyclic AMP (cAMP) level [1].Mathematical models of catabolite repression in E. coli The (isolated) reactions of the ... key players of catabolite repression. Mathematical modelling of signal transduction and gene expres-sion of the enzymes involved in the transport of carbohydrates is a promis-ing approach in biotechnology, ... E. coli A. Kremling et al.600 FEBS Journal 276 (2009) 594602 ê 2008 The Authors Journal compilation ê 2008 FEBS Catabolite repression in Escherichia coli – a comparison of modelling approaches Andreas...
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Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression profiling ppt
... Vitellogenin, in the mosquito Aedes aegypti. Mol Cell Endocrinol 267, 97–105.20 Velarde RA, Robinson GE & Fahrbach SE (2006) Nuclear receptors of the honey bee: annotation and expression in the ... reorganization of the follicular epithelium in the resulting adults [40]. DmE75A and DmE75Bhave been implicated in defining the transition stages8 and 9 of the egg chambers through either inducingor suppressing ... Interestingly, during the initialprocess of identifying the NR family members in the A. aegypti genome, we predicted two isoforms ofAaFTZ-F1, differing only in their A ⁄ B region, asobserved for the...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... regionincluding the hydrophobic segment of the C-terminal domain is essential for both the client binding and dimer formation of the HSP90-family molecular chaperone and that the dimeric configuration appears ... C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone Shin-ichi Yamada1,2, Toshio Ono2, Akio Mizuno1 and Takayuki K. Nemoto21Division ... binding activity. The binding activity of the C-terminal domain (100%) or its mutated forms toward the middle- C-terminal domains was quantified as the b-galactosidase activity of the bacterial two-hybrid...
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Báo cáo khoa học: "Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40" ppsx
... evaluation of staining, manuscript. IN was involved in the evaluation of staining, results. MS, RH, CV were involved in clinicaldata and details, discussion. IH, BP were involved in sta-tistical evaluation, ... the predictive value fornodal metastasizing of lymphatic vessel invasion (L1)using the conventional and immunohistochemical method in squamous cell carcinomas (SCC) of larynx and hypopharynx. ... lymphatic vessels and improves the search for L1. However, theimportance of this immunohistochemical staining was not investigated in squamous cell carcinomas (SCC) of larynx and hypopharynx. Aim:...
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Báo cáo khoa học: "Pancreatic adenocarcinoma in a patient with Situs Inversus: a case report of this rare coincidence" pot
... CentralPage 1 of 4(page number not for citation purposes)World Journal of Surgical OncologyOpen Access Case report Pancreatic adenocarcinoma in a patient with Situs Inversus: a case report of ... are at increased risk of malignancy.Since that time there have been no new reported cases of pancreaticoduodenectomy in SI patients. We present a case of a patient with SI who developed a pancreatic ... presence of several associated anatomic abnormali-ties, such as a midline gallbladder or liver, rotationalabnormalities of the small and large intestine, interrup-tion of the inferior vena cava,...
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báo cáo khoa học: " An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models" ppt
... Importantly, primary breast cultures retain progenitor/ stem cell populations [7].Using primary cultures from human breast tumour and non -tumour tissue, we sought to define correlationsbetween progenitor ... Arnold DK Hill1and Ann M Hopkins1*AbstractBackground: Many factors in fluence breast cancer progression, including the ability of progenitor cells to sustainor increase net tumour cell numbers. ... Clinical Cancer Research 2011, 30:45http://www.jeccr.com/content/30/1/45Page 7 of 10 RESEARCH Open Access An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary...
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báo cáo khoa học: " Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw" docx
... 7:16http://www.head-face-med.com/content/7/1/16Page 3 of 6 CASE REP O R T Open Access Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jawLuigi Cella1, Aldo Oppici1, ... offered the opportunity to our patient of injection of autologous bone marrow stem cells into the osteonecro sis sitelesion.MethodsIn september 2008 the patient (who is the mother of one of ... are stem cell the answers for bone disease of the jaw? Head & Face Medicine 2011,7:5.doi:10.1186/1746-160X-7-16Cite this article as: Cella et al.: Autologous bone marrow stem cell intralesional...
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báo cáo khoa học: " Pollen development in Annona cherimola Mill. (Annonaceae). Implications for the evolution of aggregated pollen" pdf
... the pollen grains to undergo the 180° turning [22,23]. In the formation of the pollen wall,callose dissolution occurs concomitantly with the layering of the exine [54] and the formation of the ... and the development of inward facing intines may play a role in protecting pollen against desiccation.Conclusion The results obtained in this work support the hypothesisthat aggregated pollen ... present just in the microsporeintine (Figure 4B). The exine showed a low unspecific Pollen development within the tapetal chamber in Annona cherimolaFigure 3 Pollen development within the tapetal...
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