... 4705 In the p21 50-mer target and its derivatives p21a and p21b, the 5¢-neighboring guanines in the ‘top’strand form another GG doublet with the first guanine of the p53DBS (Fig. 1). Interestingly, ... accommodate the cisplatin IACs. The higher the probability of formation of the cisplatinIACs within the p53DBSs due to the occurrence of the GG, AG and ⁄ or GNG motifs, the stronger the inhibition of the ... withcisplatin on the binding of two p73 isoforms, p73d and p73b, to the p21 target site (Fig. 5). The intensity of the resulting R73dband decreased almost linearly withincrease in the cis-platination...