Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt

... transcription of an array of inflammatory genes, their direct regulation of MMP transcription is just beginning to be elucidated. In the remainder of this review, we address how these pathway-specific ... arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors Matthew P Vincenti 1 and Constance...

Ngày tải lên: 09/08/2014, 03:24

... target genes at different developmental stages. Therefore, the interplay among the various transcription factors involving their stage of expression, type of cells expressing them, the combination of ... implications for the interactions among the transcription factors. Many of the erythropoietic transcription factors are complex, multidomain proteins. Different...

Ngày tải lên: 08/03/2014, 22:20

... motifs using Scansite [23] predicts a high-stringency target site for phosphorylation by protein kinase C-ε (PKCε) within the amino-terminal region of KLF17. Given that the activity of some ... might play a role in the regulation of invasion and metastasis in different cancer types. Figure 1 Regulation of ID1 expression by KLF17. ID1 transcription is suppressed b...

Ngày tải lên: 09/08/2014, 20:20

... on the basis of the intensity value for the PCR product on the gel (as assessed by the IPLab Gel software) relative to the intensity value for the 676-bp band in the molecular mass standard. The ... the type of inflammation seen in mtDNA-injected mouse joints. It is also worth emphasizing that the process of inflammation in RA joints is dynamic, with the...

Ngày tải lên: 09/08/2014, 01:23

... ethnic minority area. Materials and methods Study area The present study was undertaken in Gongshan County, NW Yunnan of China. The County is situated in the northwest end of Yunnan province, between ... equally during the field work, data analysis and preparation of the manuscript, and read and approved the final manuscript. Competing interests The authors declare tha...

Ngày tải lên: 10/08/2014, 09:21

... effective in inhibiting the activity of purified recombin- ant MTE-I in an in vitro assay performed in a Hepes-based buffer containing only KCl. Information about the tertiary structure and of ion ... activity of the enzyme (data not shown). NDGA is known to inhibit the activity of lipoxygenase by binding to the reduced form (Fe 2+ )oftheenzyme thereby keeping it inac...

Ngày tải lên: 08/03/2014, 09:20

... cells. A very rapid increase of the hydA transcript was detected in the first 3 0 min of anaerobiosis. This quick increase of gene transcription is only reported for the cyc6 gene in C. reinhardtii ... that the induction of the anaerobic proteins is the result of a n increased mRNA level. Maize (Zea mays L.) responds to anaerobic stress by redirect- ing t he synth...

Ngày tải lên: 08/03/2014, 22:20

... desferrioxamine biosynthe- sis is the decarboxylation of lysine by a lysine decarboxylase encoded by the desA gene [8,9]. Lysine decarboxylases occur in different Streptomyces species and are involved in ... source, indicating that the encoded lysine decarboxylase is a dedicated enzyme committing l-lysine to the desferrioxamine pathway, as occurs with p-aminobenzoic acid synthas...

Ngày tải lên: 16/03/2014, 11:20

... participating in both the immediate- early transcriptional response to infection and the secondary response to cytokines [3–5]. For instance, IFN-b synthesis is activated directly by virus infection in ... systematic analysis of the role played by the two sets of Ser/Thr residues in the virus-dependent activation of IRF-3. To this end, we examined the phenotypes of...

Ngày tải lên: 17/03/2014, 10:20

... activity was dramatically diminished. Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. ... morphology after induction of differentiation of HL-60 cells by dimethylsulfoxide and TPA. (A) HL-60 cells cultured in RPMI for 3 days (control for B), followed by cytospin...

Ngày tải lên: 17/03/2014, 23:20