Báo cáo khoa học: "Single site laparoscopic right hemicolectomy: an oncological feasible option" pot
Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... hasFig. 5. Analysis of the enzymatic activity of His -CoaB R206Q and A276V. The synthesis of 4Â-phosphopantothenoyl-CMP (cysteine, upper part of the gure) and of 4Â-phosphopantothenoylcysteine (+ ... important for the second-half reaction and are part of the active-site of CoaB; these residues may be directlyinvolved in binding of one of the substrates, the amino acid cysteine (Fig. 3). However, ... monomers with the monomer fold having featuresin common with a group of NAD-dependent enzymes onone hand and with the ribokinase fold on the other hand. The structure of the human PPC synthetase...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ- RGS3 protein Zhengding ... SH2 domain (i.e. pYEEI).Table 1. The effect of tyrosine phosphorylations on the binding affinity of ephrinB2(301–333) to the SH2 domain of Grb4 and to the PDZ domain of PDZ- RGS3. In the combination ... of Grb4 binds to the cytoplasmic tail of ephrin B2 in a phosphorylation- depend-ent manner. It is therefore interesting to know whether Grb4 and PDZ- RGS3 can bind to the cytoplasmic tail of ephrin...
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Báo cáo khoa học: Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase doc
... 1232–1243 ª 2011 The Authors Journal compilation ª 2011 FEBS 1241 Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase Maria Luisa Di Paolo1, ... fac-tors underlying substrate selectivity still remain to be discovered. With this in view, we examined the kinetic behaviour of pea seedling amine oxidase with cadaverine and hexylamine, the ... the monoamine is driven by hydrophobic interactions. Instead,binding of the diamine is strongly facilitated by electrostatic factors, con-trolled by polar side-chains and two titratable residues...
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Báo cáo khoa học: Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase pot
... Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase Nicola Solaroli1,2, Mia Bjerke1, Marjan H. Amiri1, ... multisubstrate deoxyribonucleoside kinase of Droso-phila melanogaster (Dm-dNK) is sequence-related tothree human deoxyribonucleoside kinases and to herpessimplex virus type-1 thymidine kinase. Dm-dNK ... Dm-dNK, Drosophila melanogaster deoxyribonucleo-side kinase; dCK, deoxycytidine kinase; dGK, deoxyguanosine kinase; TK2, thymidine kinase 2; HSV-1 TK, herpes simplex virus type-1thymidine kinase; ...
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Báo cáo khoa học: "FROM N-GRAMS TO COLLOCATIONS AN EVALUATION OF XTRACT" pot
... Stage 3, and a U collocation is rejected. The results of the use of Stage 3 on the sample set of collocations are similar to the manual evaluation in terms of numbers: about 40% of the collocations ... then sent off to the dictionary and go through several rounds of careful analysis before actually being submitted to the dictionary. The ratio of proposed can- didates to good candidates is ... Y collocations are of better quality than YY collocations. YY collocations are often too specific to be included in a dictionary, or some words are missing, etc. After Stage 2, about 20% of...
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Báo cáo khoa học: Highly site-selective stability increases by glycosylation of dihydrofolate reductase ppt
... Highly site-selective stability increases by glycosylation of dihydrofolate reductase Lai-Hock Tey1, E. Joel Loveridge1, Richard S. ... Increased thermal stability of site-selectively glycosylated dihydrofolate reductase. ChemBioChem 6, 1338–1340.15 Baek WO & Vijayalakshmi MA (1997) Effect of chemi-cal glycosylation of Rnase A ... simulation of Escher-ichia coli dihydrofolate reductase: thermal stability of protein domains and unfolding pathway. Proteins 46,308–320.42 Frieden C (1990) Refolding of Escherichia coli dihydrof-olate-reductase...
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Báo cáo khoa học: Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase docx
... (2002)]. Active site residues in aloesone synthase I. Abe et al.212 FEBS Journal 273 (2006) 208218 ê 2005 The Authors Journal compilation ê 2005 FEBS Active site residues governing substrate selectivity and polyketide ... (BIOSOFT). Active site residues in aloesone synthase I. Abe et al.214 FEBS Journal 273 (2006) 208218 ê 2005 The Authors Journal compilation ê 2005 FEBS substrate selectivity and the product chain length ... at the ‘ceiling’ of the active site cavity (Fig. 4)also plays a crucial role in the polyketide chain elonga-tion reactions in R. palmatum ALS. It is surprisingthat a single amino acid substitution...
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Báo cáo khoa học: Cleavage site analysis of a serralysin-like protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate pdf
... protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate Judit Marokha´zi1, Nikolett Mihala2, Ferenc Hudecz2,3, Andra´s ... the development of such a substrate based on analysis of PrtA cleavage site specificity, and kinetic characterization of PrtAactivity on the new substrate. Results and DiscussionIdentification of ... normalized with the internal standard, and thedegree of cleavage was calculated from the reduction in thenormalized area of the substrate peaks. For the identifica-tion of PrtA cleavage site...
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Báo cáo khóa học: Active site residues and mechanism of UDP-glucose dehydrogenase ppt
... 2003 Active site residues of UDP-glucose dehydrogenase (Eur. J. Biochem. 271)17 Active site residues and mechanism of UDP-glucose dehydrogenase Xue Ge1, Lisa C. Penney1, Ivo van de Rijn2 and ... and aldehyde dehydrogenases [7]. Other members of thisfamily include UDP-ManNAc dehydrogenase [8] and GDP-mannose dehydrogenase [9,10]. Extensive studies onboth the bovine and S. pyogenes UDP-glucose ... Branlant, G. (1992) A new chemical mechanism catalyzed by a mutated aldehyde dehydrogenase. Biochemistry 31, 12532–12535.Ó FEBS 2003 Active site residues of UDP-glucose dehydrogenase (Eur. J. Biochem....
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Báo cáo khoa học: Functional site of endogenous phospholipase A2 inhibitor from python serum Phospholipase A2 binding and anti-in¯ammatory activity ppt
... endogenous phospholipase A2 inhibitor from python serum Phospholipase A2 binding and anti-in¯ammatory activity Maung-Maung Thwin1, Ramapatna L. Satish2, Steven T. F. Chan2 and Ponnampalam Gopalakrishnakone1Venom ... IC50, concentration of the inhibitor that inhibits PLA2 activity by 50%; PIP, phospholipase inhibitor from python; PLI, phospholipase A2 inhibitor; sPLA2, secretory phospholipase A2.Note: ... Gopalakrishnakone1Venom and Toxin Research Programme, Departments of 1Anatomy and 2Surgery, Faculty of Medicine,National University of Singapore, SingaporeThe functional s ite o f phospholipase A2 inhibitor from python ...
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Báo cáo khoa học: DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine pptx
... DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine Anne Seifert, Lindsey A. Allan and Paul R. ClarkeBiomedical Research Institute, ... phosphorylation on Thr125 in cells. (A) DYRK1A directly phosphorylates caspase 9 at Thr125. Recombinant His6 caspase 9 (His–C9) or His6 caspase 9( T125A) (both containing the catalytically inactivating ... theapoptosome [9] . Apaf-1-induced dimerization of pro- caspase 9 leads to its activation and autocatalytic pro-cessing [10]. Active caspase 9 initiates a proteolyticcascade by processing and activating...
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Báo cáo khoa học: Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx
... MINIREVIEW Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors Jian-Qiang Fan1 and Satoshi Ishii21 Department of Human Genetics, Mount Sinai School of Medicine, ... thedevelopment of ASSC therapy for Fabry disease. Par-ticularly, 1-deoxygalactonojirimycin (DGJ) is exploredas an example of the development of ASSC therapy. Structural basis of Fabry disease The ... for 140 days, indicating that DGJ is well toler-ated in mice.ASSC therapy for Fabry disease inhumansThe clinical proof -of- concept for ASSC therapy hasbeen investigated in cardiac Fabry disease...
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Báo cáo khoa học: "DETERMINISTIC LEFT TO RIGHT PARSING OF TREE ADJOINING LANGUAGES*" ppt
... above and to the left of the root, we define a tree traversal of a dotted tree (as shown in the Figure 3) that will enable us to scan the frontier of an elementary tree from left to right while ... to dotted trees, s FIRST of a dotted tree corresponds to the set of left most symbols appearing below the subtree dominated by the dotted node. FOLLOW of a dotted tree defines the set of tokens ... sequence of pushdowns, the stacks are piled up from left to right. II stands for the bottom of a stack, s~ is the top element of the top stack, Sx is the bottom element of the top stack,...
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Báo cáo khoa học: "Single site laparoscopic right hemicolectomy: an oncological feasible option" pot
... AccessSingle site laparoscopic right hemicolectomy: an oncological feasible optionYon Kuei Lim, Kheng Hong Ng, Kong Weng Eu*AbstractIntroduction: We present the first 7 cases of single site right ... histology and post operative recovery and complications were collected andanalysed.Results: The median operative time was 90 mins (range 60 - 150 mins) and a median wound size of 2.5 cm (range2 ... of the right colon, with a mediantumour length of 3.5 cm and width of 2.5 cm. The med-ian operative time was 90 mins (range 60 - 150 mins),slight blood loss(less than 20 mls) and a median woundsize...
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Báo cáo khoa học: "Port site metastasis following diagnostic laparoscopy for a malignant Gastro-intestinal stromal tumour" pot
... site metastasis after diagnostic laparoscopy for upper gastrointestinal tract malignancies: an uncommonentity. Ann Surg Oncol 2002, 9(7):632-636.6. Martinez J, Targarona EM, Balagué C, Pera M, ... peritoneal cavity at the site of an existing peritoneal metastasis. As far as the authors are aware, there is only one previ-ously documented case of port site metastasis (PSM) fol-lowing laparoscopy ... precipitating event leading up topresentation. Malignant tumours often have a palpablemass at diagnosis and response to Glivec (although some-what variable) can be dramatic.Generally speaking,...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘITÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ