Báo cáo khoa học: "The diagnostic challenge of mediastinal sarcoidosis accompanying esophageal cancer" doc
Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"
... diuretics every day for many reasons, not just because of the presence of pulmo- nary congestion. Similarly, physiotherapy and use of (higher) levels of positive end-expiratory pressure are applied ... daily routine CXRs that showed one of these findings would have resulted in a change to therapy, the value of this diagnostic tool remained low (for example, 4.8% of all daily r...
Ngày tải lên: 25/10/2012, 10:39
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... One challenge investigating downregulation of the cyclin B2 promoter is that after deletion or mutation of constitutively activating sites, such as the destruction of CCAAT-boxes, small levels of ... determine a role of NF-Y in their control, a number of such genes were implicated to be regulated through CCAAT-boxes. Cotransfection of dominant-negative NF-YA demonstrated that...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
... indicate that poly- merization of Gag occurs mainly through the forma- tion of an intermediate layer of cup-shaped structures, each made of one hollow hexameric ring of CA domains placed immediately ... of the precise residues and interac- tions involved in the NTD–CTD interface [46]. Most of these involve side chains from helix 8 of the CTD which pack against the N-terminal e...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly ppt
... ring of CAP-1 inserts; the urea and dimethyla- monium groups of CAP-1 also make contacts with the side chains and ⁄ or backbones of several residues in the protein. Thus, most of the contacts of ... shifts of the whole dimer- ization helix of CTD [27] (otherwise, those chemical shifts are too broad to be observed because of the presence of interconverting conformers) [29]. T...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... experi- ments demonstrate binding of proBMP-2 to the ECD of BMPR-IA. Interaction of BMP-2 (A) and proBMP-2 (B) with immobilized ECD of BMPR-IA. Interaction of BMP-2 (C) and proBMP-2 (D) with ... effect of BMP-2 and proBMP-2 on the phosphorylation status of p38 was tested, addition of BMP-2 resulted in maximal phosphorylation of p38 after 60 min, while proBMP2 showed no induc...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... ccp 4 suite of programs [39] was used for scaling. Structure deter- mination for hACMSD was performed by means of the molecular replacement technique, using the coordi- nates of a monomer of PfACMSD ... 0.124 Multiplicity 2.6 Completeness (%) 94 Number of protein atoms 2635 Number of solvent molecules 216 Number of DHAP ⁄ Zn atoms 10 ⁄ 1 Number of glycerol atoms 6 R-factor (%)...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc
... 100 lm of (GlcNAc) 1–4 was analysed at the start, in the middle and at the end of each series of sam- ples. The resulting average values of the standards (display- ing standard deviations of < ... 4MU-(GlcNAc) 2 as substrate; 50 lL of supernatant was mixed with 50 lLof 50 mm citrate–phosphate buffer, pH 3.8, containing 50 lm of substrate and 0.1 mgÆmL )1 of bovine serum alb...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes docx
... presence of SDS, and of random coil values for a protein of the same sequence. Fig. S2. In-cell NMR. 1 H- 15 N HSQC spectra of the E. coli slurry [(A), not induced; (B), induced and of the supernatant ... spectra of J1_ic (7.0 lm) in buffer alone and in the presence of SDS (3 mm) at pH 7.4 and at pH 6. Fig. S8. CD of J1_ic. Far-UV CD spectra of J1_ic (7.0 lm) in buffer alone...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: The conformational stability of the Streptomyces coelicolor histidine-phosphocarrier protein Characterization of cold denaturation and urea–protein interactions doc
... understanding of the physical interactions underlying the structure, folding and the function of a protein requires a detailed description of its conformational stability in terms of the free energy of ... and values of the thermodynamic parameters governing the heat- and cold-denaturation processes have been obtained. Cold- denaturation of the protein is the result of the com...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx
... recognition of p NPP by the pNPP site at t he rear su rface of the N -domain is due the formation of an hydrogen bond of the NO 2 -group of pNPP with the amino group of N398. The hydrophobicity of the ... p-nitrophenylphosphate (pNPP). (B) pNPP docked to a surface around N398 at the rear site of the N-dom ain (pNPP site) of the same model. (C) Docking of pNPP to the ATP bi...
Ngày tải lên: 19/02/2014, 16:20