... viralproteins [12-14].Members of the HSP70 family contain three conserveddomains: an ATPase domain at the N-terminus, a peptidebinding domain, and a GP-rich region at the C-terminusthat contains ... factor binding sites. In Silico Biol 2002, 2:S1-15.39. Myles KM, Pierro DJ, Olson KE: Deletions in the putative cellreceptor-binding domain of Sindbis virus strain MRE16 E2glycoprotein reduce ... pathogenesis from viral infec-tions. Interestingly, a potent antiviral drug, prostaglandinA, showed antiviral effects against Sendai or Sindbis virusthrough induction of HSP70 proteins in AGMK cells...