... differentiation, we investigated the effect of miR-27 on the expression of the well-definedkey transcription factors of adipogenic differentiation,including PPARc, C ⁄ EBPa, and C ⁄ EBPb. Theirrespective ... miR-27a and miR-27b wereable to strongly inhibit the transcriptional induction of PPARc within the first day of adipogenic stimulation(Fig. 4B, day 1). Robust inhibition of both PPARc and * miR27a* ... accumulation of fat droplets, wasnot blocked by miR-27 under these experimental con-ditions. On the other hand, miR-27a or miR-27b didnot appreciably inhibit expression of PPARc and C ⁄ EBPa...